Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID76584	Afatinib	GSE92742	MCF10A	Human	6h	0.4uM	EID0440

Response Information :

Types	Number	Response transcription factors
Up-regulation	142	KLF4; FOSB; LITAF; ZNF175; DMTF1; TRPS1; MYBL2; NR3C2; NANOG; TAF9; ZMIZ1; SMARCD3; TSC22D3; SNAI2; ATOH1; SOX18; CBX2; PRRX1; ZIC1; HDAC6; TERF2; RERE; OLIG2; POU5F1B; ATF3; CBFA2T3; NKX2-2; FOXE1; NCOA2; MAF; TAF5; SP140; MMS19; TSC22D4; BBX; KLF9; LIN28A; HOXB7; SOX13; MAFB; ASXL1; BATF; CNOT3; RXRA; TAL1; DLX4; GATA1; TFDP2; IRF9; SMAD4; CBFA2T2; LZTS1; FOXN3; BRD4; ATF2; PITX2; NFE2L1; SALL1; ZNF415; EZH1; IL16; PHF8; PRDM14; SOX5; TRRAP; MED13; SOX10; SOX2; ZNF721; ZNF160; JUND; TERF1; ZNF665; BHLHE41; TCF4; TFE3; CREB3L2; COPS5; HSBP1; KLF5; NR5A2; TRIM22; COPS2; TCEA1; PRKDC; CREB3L1; IRF1; HIPK2; FOXO1; NFATC1; MTA1; VPS72; SMAD2; TP53; PPARGC1A; TOX; DEK; FOXF1; CD3D; RAD21; ZEB1; ZNF91; POU2AF1; NR2F1; BNC2; HOXC10; TEAD1; BTG1; SPDEF; ITGB3BP; ZKSCAN1; NR4A2; TWIST1; NFAT5; ID4; ZBED1; ZNF611; ZSCAN18; HLTF; BCL11A; INSR; PHIP; ZNF274; DLX5; ZFP36L2; HDAC9; BIRC2; AEBP1; SCAND1; RB1; SALL2; LEF1; TOB1; ASCL1; TRIM29; ZFP36L1; SPEN; HIC2; TCFL5; ZNF331; HOXA5; MYBL1
Down-regulation	180	FOSL1; WWC1; MYC; EYA1; PCGF1; ABT1; TTF1; ESRRA; CLOCK; TEAD4; CDYL; HDAC3; NKX3-1; NFX1; HINFP; ZNF184; ZNF571; RCOR1; PPP1R13L; ARNTL2; PAX9; MAK; ZNF227; TRIM32; EGR1; EN2; NFKB1; TRIM27; BCL6; SREBF1; SIX2; NFRKB; URI1; ZNF710; ZBED4; FOXA1; ELF2; SUB1; MYOD1; CERS6; ZNF614; NR2F2; SMAD3; GRHL2; ZSCAN12; HMGXB3; PSMD9; MYCBP; ZNF202; TAF1D; ZNF131; MECOM; MXD4; DACH1; JARID2; CBFB; RNF4; E2F6; NKRF; HMGN3; FOXJ3; CARHSP1; ZNF468; ZBTB18; MED17; STAT6; MBD2; SSBP2; ZNF384; MLLT10; ZNF593; MEF2A; SOX4; UBE3A; PRMT2; ELK3; SOX9; CREB3; HIPK3; MED6; GATA4; GATA6; ZSCAN31; BRWD1; BRD8; SIM2; BCL3; DNAJC1; FOXD1; PLAGL1; ZNF711; ZNF516; RFX5; DDX5; TAF12; PITX1; HMGXB4; RREB1; CHD9; KLF11; UIMC1; CREBZF; MEIS2; NRIP1; HMGA2; BRF2; SLC2A4RG; ZSCAN9; ZNF354A; BAZ2B; RBFOX2; CNOT6; MGA; ATF4; PHF2; YAF2; CSDE1; ALX1; ZNF432; FOSL2; BCLAF1; PSPC1; ZNF112; MSX1; CDK8; NUP62; TCF20; ESRRG; SKI; ZNF267; EDF1; TTF2; UBP1; ISL1; ZNF426; BRPF1; ZNF629; HMBOX1; MYRF; NFIB; HMGB3; FLNA; CDK9; HSF2; MED21; GATAD2A; SIAH2; YEATS2; ZNF32; TRIM28; NHLH2; KAT6B; SMAD7; BCL11B; POU4F1; KLF7; BAZ1A; ZNF22; FOXC1; EYA2; ERBB4; RFX7; CALR; TOPORS; NFE2L3; SIX1; TRIM16; PAX6; AHR; TGFB1; TFCP2; INSM1; PDLIM1; ATF7IP; MED1; SERTAD2; IRX5; CREB1; ZMYM2; HOXB2