Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID76459	Linsitinib	GSE92742	MCF10A	Human	6h	0.08uM	EID0439

Response Information :

Types	Number	Response transcription factors
Up-regulation	342	MEF2C; TRIM24; ZNF117; SOX2; IRX5; BMI1; GATA3; XBP1; MAGED1; ZNF329; PPARD; STAT5B; SKI; ELF3; SOX4; EPAS1; ZFP64; ZNF415; MDM2; HMGN3; GTF2I; BHLHE40; ZNF264; SHOX; RXRB; ACTL6B; DLX5; TOX4; ZNF768; PAX8; ING1; SPDEF; CEBPD; PIAS3; MYCN; CREB3L1; ETV6; CBFA2T3; TCF4; TRIM22; SATB1; EBF2; EHMT2; ADRB2; ZNF286A; TSC22D1; GRHL2; NFAT5; ZNF273; REPIN1; LIMD1; NCOA1; ZIM2; KMT2D; MYT1L; ZNF669; BANP; TOX; CHD1; EN2; ZMIZ2; EHMT1; NEUROD1; NR2F1; ZNF623; ONECUT2; HMGA2; ZNF492; ZNF443; ZBED1; BRCA1; DYRK1B; CREM; THAP3; ZNF692; AGO2; CRYM; ZNF652; TBX21; TGIF1; ZNF257; CHD2; POU3F4; FOXA1; ZNF682; VGLL4; ZBTB3; NFKB2; POU6F1; OSR2; TRIM27; GATA6; ZNF606; ID2; BRD3; TFDP2; TXNIP; NKRF; UBP1; MAFK; ZNF696; ZNF202; NONO; ZNF160; TRIM28; BTG1; GATA1; DDX54; HHEX; ZKSCAN3; FOXO4; ZIC1; ZNF721; MED12; FOXG1; FOXJ3; KDM5C; IKZF2; HDAC4; FOXJ2; ZNF141; ZNF253; ZBTB44; TOB1; ZEB2; MYF6; ZBTB38; TOX3; IKZF3; RARB; ZNF536; DBP; CBX6; ZNF506; NR2C2; NR1D2; IRF5; SOX9; MAF; CHD3; FOXJ1; BRDT; NKX2-2; ZNF124; ZNF423; CBL; TAF1; ZNF148; CHD4; IKZF1; E4F1; EZH1; NCOA6; HMGXB3; ZKSCAN4; ZNF224; DPF2; PCGF3; ERBB4; RFX2; STAT3; MYOD1; MLXIP; E2F5; ZFHX4; TAF7; HABP4; FOXC1; EP400; SP4; DNMT3B; KLF12; ZNF711; HES1; APBB1; CCNE1; HOXD1; LZTS1; ZBTB48; HEY1; ZFHX3; ZNF248; RERE; TGFB1I1; CALCOCO1; SMARCA2; KAT7; PIAS2; ZNF587; SIX3; CBX7; FOXE1; NCOA3; SOX11; SPIB; NCOA2; SIX1; TRAK1; ZNF430; SUPT5H; PEG3; ZSCAN16; ZNF444; ZNF665; MAML1; SERTAD2; TAF9; EYA1; TRIM32; ZNF701; ZNF574; NFIL3; DAXX; MEIS2; CUX2; GTF3A; POLR2A; KLF3; SMARCA1; ZNF175; SIAH2; CTBP2; TDP2; AHR; ZFPM2; PMS1; ZNF467; FOXF2; SOX21; ZNF419; MXD1; CAMTA1; BATF; KLF9; HLF; CDYL; HOXD3; HBP1; TRPS1; IRF2; ZNF282; KDM2A; ARID4B; ZNF85; CBX3; IRF4; BTF3; FOXF1; HMBOX1; PHF20; NRIP1; NUP62; SNAI1; HOXB13; THRA; TBX3; ST18; ZNF43; NFIC; GFI1; ZNF611; ZKSCAN7; MECP2; ZNF107; NR3C2; ATOH1; CTNNB1; IRF9; E2F2; PRRX2; SMARCA5; SCMH1; SAP130; PDLIM1; RELA; BAZ2B; PRDM2; ZNF22; SMAD5; KLF2; BCL3; ETS1; ABL1; TULP4; DLX4; ETV5; ZNF226; MECOM; NR2F6; IRF7; HNRNPD; ZNF93; EYA2; MYRF; PAX6; RUNX1; ZXDC; SMAD2; ZSCAN18; RNF141; TCF7; KAT2B; HMGA1; ERBB2; BRD2; TAF4; ZMYM2; MNT; BCL6; MXD4; PNRC1; STAT5A; CERS6; TRIM16; TCFL5; NLK; WWTR1; ZBTB18; RUVBL2; KLF5; NKX3-1; SMAD6; MYB; CD3D; TP53; SOX10; FOSL2; TERF1; PHF1; FHL2; ZNF331; CREB3L2; MYCL; SCAND1; ZNF512B; KAT6B; PBX3; RBPMS; BASP1; ZBTB20; MYBL1; RELB
Down-regulation	331	NFKBIA; IFI16; CCNA2; ID3; IKBKAP; CEBPB; CSDE1; FOXL2; HOXD11; RB1; BRD7; XRCC6; RFC1; RAN; CCNC; NFYB; TFDP1; CDK2; ZNF281; BTAF1; ZNF215; WDR77; MED16; JUN; TSC22D3; PSMC3; ZBED2; REXO4; GTF2F1; CARHSP1; SRCAP; PITX1; ETV4; FUBP1; RCOR3; FLNA; RBBP8; SND1; HOXD10; HOXA11; MAFF; TAF5; STAT6; PQBP1; MED21; TRIM33; MSL3; NCOR1; VDR; CEBPG; ZNF783; KAT8; TTF2; ESR1; SP110; ZNF143; ALX1; GMNN; ARL2BP; CREB3; NFATC3; SP140L; SETD3; ATF5; ZNF787; RRN3; ZNF473; RFXAP; ZNF576; TAL1; SHOX2; RFXANK; EMX2; BPTF; ZNF654; PCGF1; TBP; ZNF177; KDM5B; MED23; SOX15; HMGB2; ZNF146; NR0B2; WWC1; NFX1; TBPL1; KLF6; EDF1; UBE2L3; MED1; RBM39; ANKRD1; SAFB2; EED; SUPT3H; FOSB; E2F4; FOSL1; ZNF668; PPRC1; MED4; ZNF593; ZNF83; MMS19; UTF1; ATF4; ZBED4; PSIP1; ZNF410; MYBL2; ATF6; MLXIPL; PMF1; L3MBTL1; TWIST1; ATF2; FOXI1; CITED2; CIZ1; SUV39H1; ID1; HCFC2; ELK4; TRIP4; BAZ1A; MED31; FOXO1; MYC; ZNF232; ZNF516; HDAC1; HOXD9; TCERG1; SNAI2; VEZF1; NR1I2; SAP18; ELK3; UBE3A; TOPORS; TULP3; ZNF12; TP63; HAND1; ZNF667; SMAD9; PGR; RSF1; TTF1; HDAC2; E2F3; PAXBP1; PRKDC; ZNF426; MTF2; NR4A3; CRTC1; TAF1A; ILF2; ZMYND11; DEK; LBX1; CDK8; PIAS4; CENPF; BRD8; NFYC; UBE2I; TAF11; COPS2; GATA4; SNAPC4; SIX6; MED6; MSX1; MDFI; CALR; ASH2L; MBD4; NR4A1; MED17; PPP1R13L; ARNT; CARM1; EGR3; RORC; POLR3F; ZNF263; HDAC9; SREBF1; SMARCD2; TBX2; CLOCK; SMARCB1; RHOA; SRF; YAF2; SMAD3; TSHZ2; TCF21; TBL1XR1; ELF1; C1QBP; ENO1; EN1; ABT1; LPIN2; FLI1; GMEB2; SMAD1; MAFG; SOX17; SSRP1; RNF14; TBX19; HOXA4; EGR4; TMF1; ZNF432; EHF; CCDC59; ZMYND8; TFE3; CDC5L; ZNF274; TEAD4; CDX1; ITGB3BP; PA2G4; BAZ1B; BATF3; RNF138; RCOR1; DNMT1; THAP11; DR1; FOXM1; GABPA; TGFB1; SMARCE1; RYBP; MAZ; EZH2; ZNF580; TRAF6; AATF; INSM1; ZBTB1; PCGF2; PTTG1; BRIP1; TAF10; KLF7; MLX; SF1; C1D; SUPT4H1; NFIB; FOS; MXI1; REST; JAK2; RLF; MTA1; ZBTB7A; ID4; HEY2; HOXA10; ERG; GLI3; NR2C1; BLZF1; CNOT1; RNF6; CNOT3; ARID5B; CREBZF; NPAS2; BIRC2; PATZ1; ESRRG; CREG1; PBRM1; MYCBP; THRAP3; ASCL1; DNAJC2; MITF; WT1; AR; PLAGL2; SIRT7; SMAD7; PTRF; ZNF23; ZBTB16; FOXA2; BHLHE41; MED14; PSMD9; CBFB; PPARGC1A; TLE4; LOXL2; NFKB1; ZMIZ1; NR1H2; TLE1; PBX2; JUND; MAFB; BNC2; CRY1; HOXB2; ZNF217; APEX1; USP22; TLE2; PBX1; POU2AF1; TSC22D2; SALL1; SSBP2; TRIM29; RFX5; SATB2; STAT1; TFEC; TCEA2; CREB1