Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID76387	Afatinib	GSE92742	MCF10A	Human	6h	0.4uM	EID0439

Response Information :

Types	Number	Response transcription factors
Up-regulation	349	IKZF1; MNAT1; SOX2; TRIM24; NFATC1; PPARD; FOXL2; BRPF1; ZNF329; NKX3-2; IL16; RORA; THRB; FOXN3; CEBPD; BATF; ZFPM2; SOHLH2; ZKSCAN3; POU4F1; OVOL2; ZIM2; ZIC3; FOXF1; SP140; HOXC10; CEBPA; SKI; XBP1; BHLHE40; KDM4A; LZTR1; NUP62; CREM; HOXD3; TOX; CREBL2; IRX5; NFYC; ARNTL; MAF; SOX4; HOXA1; SUPT5H; IRF7; ZNF444; TXNIP; ING1; ZNF276; FOXJ2; ZSCAN31; TGIF1; KLF3; SOX10; MYCN; STAT5B; ZBTB48; SALL2; IRF5; HMGXB3; HR; HNF1B; CDYL; SNAPC4; MLLT1; HHEX; GCM1; CXXC1; RARA; LHX3; KDM5D; CREB3L1; EHMT1; PKNOX2; IRF4; OSR2; TADA3; SATB1; SSX3; HOXC5; KLF12; KDM4C; TULP2; HIC1; HIVEP3; ZNF141; CDIP1; ZNF589; CBFA2T3; MBD1; NCOA1; CSDC2; DDX54; FOXG1; TGIF2; BLM; HMGN3; BNC1; GBX2; ZNF536; PAWR; CBX4; VGLL4; TRIM22; GATA6; PCGF3; BPTF; SATB2; CHD2; BRD2; CBL; SOX5; VAX2; EN2; TFAP2C; TOB1; TRAK1; BRD7; HOXC11; TEF; ZFHX4; AIP; MNX1; SHOX2; ARNT; ZNF225; PRDM14; ZNF571; KDM5A; POU2AF1; TBL1X; FOXJ3; NKRF; LIMD1; ZFHX3; ATF7IP; AGO2; ZNF391; THAP7; NFAT5; ZNF682; TULP4; TOX3; RBPJ; ZNF227; SHOX; BBX; TAF1C; TOX4; JUNB; GFI1; ZNF180; NFKB2; RFX2; NR2C2; NEUROD1; SPIB; NR3C2; KLF10; NR2F1; GTF2I; TRIM27; HDAC1; NFRKB; SOX21; PBXIP1; ZNF76; HDAC6; DBP; ZBTB25; KAT2B; ZNF384; PRMT2; UBE2B; NHLH1; IRF9; CBX2; ZNF215; SP110; HESX1; ZBTB7B; REPIN1; GRHL2; RING1; BARX1; FOXD3; MDM2; NFX1; CNOT1; VGLL1; ZKSCAN5; BRD3; PRDM1; ONECUT2; ZNF254; AFF2; POU2F3; TERF1; ZNF576; ZHX2; HOXA2; ZNF148; RBM14; ZNF711; AIRE; BRDT; YBX2; BANP; ARRB1; BRCA1; RXRA; VENTX; EN1; ZNF415; TEAD3; WT1; SIX1; CAMTA2; FOXE1; ZNF556; POU1F1; NKX2-2; SSBP3; SSX1; RARG; TWIST1; NEUROD2; SLC2A4RG; FOXF2; DR1; ZNF835; CNBP; PML; SNAI1; KLF4; NR5A2; ELF3; SMARCA1; STAT3; MXD4; HMGA2; ZIC1; BTG1; NFKB1; TRIM25; ZNF155; LIN28A; TRPS1; TRIM32; HOXA11; ARID3A; ZNF692; HOXA10; KLF9; ARID4A; PRDM2; RBL2; ING2; MECOM; DAXX; PRDM12; LYL1; SP3; LPIN2; AEBP1; ESRRA; SIX3; NR2E1; NR1H4; ZNF331; NRBF2; EP400; ZEB2; ZNF219; NONO; JARID2; RNF10; NR1D2; ABL1; ZSCAN12; PLAG1; SSBP2; LZTS1; NANOG; OLIG2; ZNF175; HSBP1; SMAD7; ZNF467; SALL1; SMAD2; ZNF45; SMARCB1; MEN1; ATF6; HEY1; FOSL2; STAT5A; TAF6; ZNF423; DLX5; DNMT3B; DLX4; ERBB2; ZMIZ2; BCL11B; KAT7; PAX5; HOXB13; ZBTB1; ZXDC; ERBB4; BCL3; ZNF253; PAX6; CREB1; TCF7L1; HDAC4; MTA1; SAP130; FOXC1; MEIS1; JUP; MED27; MEIS2; PEG3; NLK; NFE2L2; MYT1L; AR; TCF4; AHR; BASP1; HOXC6; ZNF226; MNDA; NFE2L3; SMAD3; PHF1; ESR1; THAP11; EGR2; E2F2; ZFP36L1; NR2F6; BIRC2; PSMD9; TLE4; NR4A2
Down-regulation	359	YBX3; CCNA2; IKBKAP; ZNF337; NFKBIA; CRK; FUBP1; RRN3; ATF2; IFI16; CEBPB; KAT6A; ID3; RCOR3; ZNF721; CARM1; ETV4; ZNF611; BTAF1; CARHSP1; CENPF; ZNF83; PMS1; ZNF593; BMI1; TCERG1; ZNF551; COPS5; SUZ12; ZNF136; NCOA4; RNF6; TSC22D1; XRCC6; ZNF12; POLR3F; CHD9; MED17; PSMC3; ZNF22; KLF1; KDM5B; HOXB3; SRCAP; ATF1; NR2C1; ADRB2; NFIL3; KLF6; FLNA; ID1; CTBP2; MYC; ZNF652; ELK4; RFXAP; MED25; WWTR1; PAXBP1; ZNF143; ZNF205; RB1; TBP; CBX3; ZKSCAN1; PRKDC; IRF1; ZNF426; ZFX; CDC5L; HDAC7; ZMYND11; CLOCK; ZBTB7A; EWSR1; ZFP36L2; HBP1; NCOR1; ZNF432; ZNF160; TMF1; ZNF473; CIR1; NFIB; MDFI; USP22; CHD8; ZBTB11; TAF11; DDIT3; ZNF408; RORC; CHD7; ZNF195; TAL1; SAP18; GMNN; CDK8; ZNF667; RFC1; MEF2D; NFATC3; SMARCC2; SUMO1; HIPK2; RAD21; INSR; ELF2; USP16; HOXB1; MTDH; EED; POU2F1; HDAC2; BCL10; RNF14; SMARCA5; MSL3; ARID1A; ZNF783; MEOX1; PA2G4; BCLAF1; HOXB5; PPRC1; ZBED4; MTF1; YAF2; CTBP1; UBE3A; HOXB6; ETS1; GABPB1; ZNF665; ZNF562; TGS1; RBM39; ZNF281; ZNF224; L3MBTL1; TBX10; MED23; ZNF44; MED14; SMARCD1; MMS19; MAFG; ATF5; ERF; TTF1; SUB1; TCEA1; UIMC1; TFCP2; ZNF787; ZNF177; CITED2; ZNF266; MAFF; SP140L; GMEB1; NKX2-5; ZNF468; TAF1A; BRD8; CREB5; FOSB; RCOR1; NELFB; PSIP1; ATF3; TTF2; PMF1; BCL6; NFE2L1; PLAGL2; CRY1; MXD3; NCOA6; ZBTB39; TOPORS; YWHAB; MGA; ZNF430; ZNF135; KLF5; ACTL6A; ZNF771; MTF2; TBPL1; CNOT6; HIVEP1; ZNF189; ZNF292; TRAF6; GATAD2A; ZNF654; STAT6; ZNF264; MXI1; ZNF529; ZNF32; ZBTB17; ZNF302; HMGB3; MAML1; FOXA1; ASXL1; SSRP1; EHF; ZNF232; HMGB2; KAT5; ZMYND8; ZMIZ1; SPDEF; C1QBP; SNAI2; ZBED2; BRIP1; GABPA; KDM5C; WDR77; SMAD4; TCF7L2; THAP4; SCAND1; TSG101; BRF2; HOXA7; PHF2; ZNF639; REXO4; TSHZ2; PSPC1; PCGF2; FOS; RHOA; TFAM; HOXB7; PAX9; CTR9; RNF4; HIRA; MLXIPL; HMGB1; ANKRD1; ERG; HIPK3; TAF1D; MYBL2; MNT; PGR; SOX9; SMAD1; MED7; NKX3-1; RERE; ZMYM2; PBX1; DLX2; HES1; CBX5; ZNF350; BAZ1A; ORC2; VPS72; E2F3; ZNF304; RFX5; HSF2; ARID5B; GMEB2; SAP30; PBX3; KMT2A; HOXB2; TULP3; PDLIM1; DEK; KAT8; HDAC9; TSC22D3; INSM1; KLF7; SOX15; ADNP; MED1; SMARCE1; PIAS1; ZEB1; CCNC; TGFB1; SIAH2; PBX2; GLI3; HLX; TAF10; NFIC; ZNF43; NAB2; PBRM1; ITGB3BP; TLE1; PHF20; UBE2I; SPEN; CTNNB1; RREB1; ENO1; ZBTB18; MAZ; CREBZF; COPS2; TCFL5; TCF12; EMX2; ARNTL2; HMBOX1; CBFA2T2; FOXO1; STAT1; ZNF23; MECP2; RYBP; FHL2; MSX1; KAT6B; TEAD4; PNRC1; CEBPG; PLAGL1; TRIM29; MITF; TSC22D2; FOXN2; JUND; LITAF; ETV1; CCDC59; MED13; THAP10; FOSL1; PHF8; CEBPZ; TBL1XR1; NR1H2; SIRT7; E2F8; YAP1; CALR; NRIP1; SOX11; KLF2; ZNF91; AFF1; BHLHE41; PTTG1; ID4