Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID76271	Linsitinib	GSE92742	MCF10A	Human	24h	2uM	EID0438

Response Information :

Types	Number	Response transcription factors
Up-regulation	139	ZNF586; IRF9; ZNF268; TSC22D3; ZNF544; SATB1; HBP1; TBX3; PHIP; ZNF492; ZNF117; IRF7; ZNF140; ATF3; ZNF623; ZNF43; ZNF12; ZNF688; ZNF611; ZNF257; STAT4; ZNF350; DAXX; ING4; ZNF304; ZNF91; SOX2; ZNF606; LOXL2; APBB1; ZNF135; ZNF562; ZNF44; ZNF345; CNOT1; TAL1; ZNF136; BLZF1; POLR3C; NFE2; ZNF266; GATA3; TBX21; ZNF160; ZBTB20; RBPJ; ZMYND8; ZNF195; NR2C1; TRIM22; ZNF83; CBFA2T2; TGIF1; GON4L; ZNF665; ERBB4; ZIC3; IRF8; ERBB2; IRF6; HOXD1; ZMIZ1; NONO; KLF1; PHF20; ARL2BP; BRD8; ZNF354A; UBE2B; DACH1; PNRC1; SPDEF; TCEB2; ZNF423; TFEC; HMBOX1; TCF4; ZNF329; ZNF551; TERF1; TLE4; SP110; ZNF415; ZNF721; BTF3; PHF1; ST18; TAF7; SIRT2; ZNF264; BTG1; KAT2B; MED14; FOXO3; RNF14; SCAND1; ZNF217; ZNF165; TOX3; FOXA1; ZNF85; ZFPM2; TFAP2A; MAF; PFDN5; TCEA1; MECOM; NFKB1; TDP2; EMX2; MXI1; ARID5B; MNDA; NCOA2; TCF7; ZFP36L1; RORA; NKX3-1; ID4; CREBL2; KLF2; TP63; NFE2L3; LIN28A; SMAD7; TSC22D1; TXNIP; JUP; MYB; CBFA2T3; IFI16; CTBP2; POU2AF1; GATA6; ZNF274; ATF5; TRIB3; STAT1; CREG1
Down-regulation	128	CENPF; MTDH; PKNOX2; WWTR1; RBM14; HOXA11; PTTG1; ELF1; RUVBL2; MSX1; FOXM1; PSIP1; WHSC1; MED21; NFKBIB; BLM; MED1; NELFB; MED6; EDF1; KLF4; ID3; PITX1; YAF2; HSF2; REXO4; SFPQ; PBX3; POU3F2; RARA; MED27; HOXC10; SMAD5; RNF138; FOXJ3; PIAS2; HDAC1; EYA1; SETD2; PIR; DNAJC2; HOXB7; NEDD8; HES1; IKZF5; IKBKAP; E2F6; HMGB2; TRIM32; ORC2; CITED1; SERTAD2; ZBTB11; ING3; NR2F2; FLNA; BATF3; TAF10; MAZ; TEAD4; TTF1; POLR2A; BRCA1; MLX; HDAC5; NFYC; TCF7L1; HEY1; AGO2; BCLAF1; SIX2; KLF9; HNRNPD; PLAG1; CREB3L2; PCGF2; ETV5; CBX5; CCNA2; KAT7; FOXC1; NUP62; HOXB6; SAP30; RXRA; BRD3; MEF2A; SALL1; SP3; BBX; LZTS1; HMGA2; SSRP1; ASCL1; TGFB1; SIAH2; PCGF1; MKL2; SMARCA2; BHLHE40; MTF2; THAP11; HDAC9; BAZ1A; NR2F6; ATF4; MYCBP; JARID2; HHEX; FOXL2; E2F5; NR2F1; KLF10; LEF1; HIPK3; ELF5; BMI1; MEIS1; ISL1; SATB2; SPEN; SUV39H1; PPARG; NR1H2; CALR; HTATIP2; ETS2; KDM5D