Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID76192	Afatinib	GSE92742	MCF10A	Human	24h	10uM	EID0438

Response Information :

Types	Number	Response transcription factors
Up-regulation	167	IRF9; TBX3; TSC22D3; CSDC2; MED15; ING4; KDM5A; ZHX2; SOX17; ATF3; PNRC1; CBX7; HBP1; HEY1; SSBP2; GATA3; SOX13; PRDM2; TEAD3; IRF6; PHIP; PBXIP1; CALCOCO1; ELF4; SSBP3; MEIS2; ZNF74; INSM1; TRPS1; ZIC1; TRIM29; CDK2; PSPC1; RBL2; PQBP1; TBX21; NFIC; CIR1; ZNF611; PIAS4; MXI1; TAF7; ARID5A; TFAP2C; ZNF350; TCF7L1; TCF25; BHLHE41; KLF13; TBX10; ZNF768; ZNF500; ZNF32; RSF1; HDAC5; AR; WWP1; NR4A3; PFDN5; PIAS1; ZNF573; MYCL; CD3D; TULP3; KLF9; SATB1; ZNF623; CREBL2; ZNF652; AES; ATN1; LITAF; SUPT3H; PGR; PBX2; HMBOX1; ZNF467; ERBB4; OSR2; ZNF557; FOXE1; SRCAP; PHF1; SOX3; ZMYM2; BTG1; NFATC4; HIC2; TCF7L2; ARNT2; CTBP1; NR2C1; HIPK1; SALL2; MECOM; THAP11; ZBTB16; SNAI2; SOHLH2; CENPB; ZNF331; IRF7; NR4A1; ZNF358; TAF11; WNT4; CCNH; CUX2; HOXB13; BCL11A; JUP; DLX2; ZNF160; SHOX2; ZNF423; ZNF91; EPAS1; KDM5C; SUV39H1; KAT2B; SPDEF; ZNF33B; FOXO3; ZNF266; TFAP2A; JUND; THAP7; ZNF195; RORA; EYA2; RING1; MEIS1; JAK2; TP63; ZBED1; DLX5; EHF; TWIST1; HOXD1; NCOA2; GATA6; DACH1; ZKSCAN1; ARID1A; RUNX3; ARID5B; LIN28A; HOXB2; NR1H2; NPAS2; MYBL1; TCF7; CALR; TCEA1; TCF4; CREG1; FOSL2; EMX2; SPEN; CBFA2T3; SMAD7; ZNF131; ZFPM2; TRIB3; FOSB; HTATIP2; FOXG1
Down-regulation	197	PARP1; CENPF; PTTG1; IKBKAP; CCNA2; EZH2; SMARCA4; RHOA; FOSL1; MED1; ELK3; WWTR1; XBP1; HNRNPD; CTR9; RUVBL2; REST; HLTF; CARHSP1; C1QBP; DRAP1; RNF138; WHSC1; HDAC2; GABPB1; TCERG1; TRIM25; UBE2I; EDF1; HOXB7; ETV1; CCNC; NUP62; MSX1; RBM14; BLM; RUVBL1; UIMC1; AATF; RFC1; EED; BRCA1; SMARCA5; CHAF1B; PMS1; ZBTB24; PSMC3IP; FOXJ3; DR1; BCLAF1; FOXM1; TBP; SUZ12; ETV5; ERCC2; C1D; YEATS4; HMGB2; MYCBP; BIRC2; ING1; CEBPZ; RAN; WDHD1; NFKBIB; GTF2A2; TRIM28; EGR1; NRBF2; CBX3; BAZ1A; SFPQ; ING2; PPRC1; TAF1A; HMG20A; BAZ1B; ZBTB11; SNIP1; RBBP8; PSIP1; ACTL6A; TRAK1; ZNF587; YBX1; PLAGL2; ZNF143; SMARCE1; ZMYND11; CCDC59; SAP30; MED7; ORC2; TBL1X; CCNE1; NRIP1; TMF1; RLF; RFX5; MEOX2; BATF3; BHLHE40; POLR2A; E2F6; HSF2; HMGA2; TAF10; EGR4; CHD7; NFX1; TRIM32; HIF1A; RBBP7; CBFB; RCOR1; PCGF2; NR1I2; MAGED1; DDX5; MAFB; MNAT1; SMAD2; BRD3; CDYL; ASH2L; SMAD1; ZBTB1; PITX1; STAT3; WDR77; KMT2B; DNMT3B; ZNF267; EGR2; TSC22D2; EGR3; HMGB3; VEZF1; MBD2; SOX11; ZNF302; ITGB3BP; ARNTL2; IL16; KLF10; IRX5; RNF141; ZNF211; CLOCK; SREBF1; LPIN2; PBRM1; ZNF329; TOB1; HOXC6; EBF2; ZMYND8; KDM5D; ZFP64; NR2F6; USP16; NLK; NFKB1; CREB1; ERBB2; FOXO1; NAB1; CRY1; ZBED2; MYBL2; HMGN3; IRF4; IRF8; NFE2L3; YWHAB; TSC22D1; BASP1; BMI1; ASCL1; BCL3; PPARG; FLNA; ZFP36L1; PAX5; NFIB; USP22; TOPORS; ID3; POU2AF1; ATF5; KDM5B; SATB2; NR2F2; PEG3; NR1D2; SOX9; RELB