Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID74901	Roscovitine	GSE92742	MCF10A	Human	24h	2uM	EID0431

Response Information :

Types	Number	Response transcription factors
Up-regulation	293	FOXO4; NFKBIB; EGR2; SOX2; HDAC6; BRWD1; PPARD; STAT5B; CREB3L1; ETV1; LIMD1; FOXF1; TGFB1I1; GLI2; PAX8; ZNF75D; MED14; RNF14; LOXL2; ATOH1; MYBL2; NAB2; HIC1; UBTF; KLF3; TBL1X; POU2AF1; TBL1XR1; OLIG2; FOXE1; GTF2I; TCF21; ZHX3; USP21; ZNF835; EHMT1; FOXO1; YEATS4; NR2F1; ZNF446; ETV5; UBE3A; CBX2; STAT2; ZNF419; CAMTA2; SETDB1; ZNF473; E2F1; MBD2; MECOM; IRF7; CENPB; CAPN15; TSHZ2; SATB2; HSF1; NRBF2; IRF3; ZBTB1; ZNF816; SMAD2; ZNF343; KMT5A; HDAC4; MAF; ZNF550; TAF4B; CREM; BCL6; ZNF354A; NFATC4; CBL; NFYA; TDRD3; ZNF211; PBXIP1; SPIB; MSL3; ZFPM2; PAX5; ZNF768; AFF2; ARID5A; HMX1; EN2; ZBTB7B; TSG101; KLF12; ZNF263; ZNF711; SPI1; PML; ZNF83; ZFHX3; TCF15; HSF4; GTF2F1; NKX2-1; TEF; ZNF646; ZNF267; KAT8; SP110; ZNF250; GABPA; CAMTA1; FLNA; CNOT6; HR; IL16; TULP2; TLX3; SUPT6H; ARNT; POU6F2; THRAP3; ZSCAN16; SP1; CDK9; MED25; TAF11; ZNF580; BARX1; CBFA2T2; HMGXB3; RB1; EHMT2; NR3C2; NKX3-2; DBP; ZSCAN31; SIX6; ZNF444; MBD1; ASH1L; CRTC1; BRIP1; LYL1; ZNF668; CDX2; ZNF787; CNOT2; BLM; ETV6; IRF8; FOXH1; MYOG; RNF138; SERTAD2; TLE4; SUPT3H; SAP18; ING1; TRAF6; SOX21; ELF1; BMI1; DYRK1B; CIITA; POLR3C; CBFA2T3; MEF2D; PIAS2; RUNX1; ZNF500; AEBP1; BPTF; CDX1; ZNF394; ZBTB25; HMG20B; MAX; TCF3; ZSCAN5A; GFI1; ARHGAP35; CARM1; ETV7; MLXIPL; WHSC1L1; PRDM2; ZNF7; MZF1; KLF15; EP400; SP140; AES; CREG1; ZNF184; HIVEP2; GLI3; UBE2L3; AHR; ASXL1; ZBED4; GATA1; APBB1; PCGF1; HMGA1; TCF4; ZNF304; PPARGC1A; GMNN; USP16; TEAD3; HOXB13; ZNF556; PBX1; CALR; WWTR1; MAZ; SOX5; CREB5; ZNF12; GATA4; DEAF1; TADA2A; TADA3; NHLH1; ZNF510; TGIF1; TBX21; SIAH2; ZNF177; MLLT10; IRF4; ZNF688; PBX2; TFCP2L1; KDM4C; FOXN3; TERF2; ERF; IKZF5; ING2; CALCOCO1; SP100; CEBPZ; TAF7; DNMT1; ZNF248; SUPT7L; STAT6; ZFP36L1; ZNF239; MDM2; ZNF217; AGO2; ZNF629; GRHL2; CNOT3; ASCL1; TOX; ZNF573; NEUROD1; VDR; SMARCD2; ZNF175; BACH2; MYB; SMARCA2; BACH1; ETV4; RARG; ZNF281; HMG20A; HDAC1; LZTS1; EHF; FOXI1; KLF7; EYA2; PAXBP1; KLF9; TCF7; KLF4; SOX11; MLXIP; MAFB; CHD7; TRIM22; JUP; ZSCAN18; BNC2; NR1D2; PHF20; ZNF232; EGR3; MNDA; BASP1; KDM5B; PEG3
Down-regulation	320	MYC; DRAP1; ENO1; CRK; CDK7; MYCBP; TFDP1; NFKBIA; PCBD1; ATF1; PARP1; MDFI; HMGB1; BRD7; CEBPB; HMGA2; RHOA; PMF1; CBX5; ZNF302; PEX14; NPM1; SIX2; HNRNPD; TULP3; HMGN3; CSDE1; YBX1; PPP1R13L; TCEB2; ZFP36L2; ZZZ3; RAN; THAP10; PIAS1; CNOT1; USP22; SREBF1; PFDN5; DPF2; CCNH; ESR1; PNRC1; NACA; COPS5; RYBP; CTCF; HDGF; RFC1; GTF2IRD1; HSBP1; HOXD1; TP53; PIR; SSRP1; XRCC6; TAF1A; ELK3; NR2F2; VEZF1; SOX15; ZNF426; BTF3; MED16; EWSR1; ARID1A; TERF1; ZNF576; UBE2B; PIAS4; BAZ2A; PTTG1; ZNF408; ZNF91; SFPQ; MSX1; ZNF593; TRIM29; CCNE1; NFKB1; THRA; NR1H3; ZNF43; TSC22D2; MAFG; YAF2; PREB; MED13; NONO; BTAF1; JARID2; PLAGL1; GATAD2A; HOXB2; CCNC; ITGB3BP; CDC5L; ZNF783; MED27; THAP11; TCEA2; NFRKB; BLZF1; SUPT4H1; HBP1; RBBP7; YEATS2; ZNF22; FOS; REXO4; MITF; ZNF140; TRIM16; MED24; PPARG; SALL2; BAZ1A; SP3; MED17; SMARCD1; TTF2; CHD9; TGFB1; SMARCC2; BANP; CREBZF; THAP4; MTF1; NR0B1; BAZ1B; ZKSCAN1; APEX1; TGS1; TAF5; ZBTB16; TCF7L1; C1QBP; TCEA1; YAP1; NR2C1; NCOA2; SUMO1; PRRX2; TOX3; ADNP; ENY2; ZMYND8; POLR2A; TCF7L2; KAT7; MED6; TOB1; RELA; SAFB; MED15; ZNF32; PA2G4; RBL2; SMARCD3; PITX1; BRD8; SND1; CARHSP1; SRCAP; URI1; RBBP4; ZBTB11; ST18; CTR9; ZNF430; TMF1; TTF1; ZNF44; UBE2I; LDB1; CRY1; CREB3L2; SHOX2; FHL5; ARL2BP; SAP30; PSPC1; ZNF652; ZNF93; STAT4; SOX9; TAF9; COPS2; SMAD4; PRKDC; HLX; CNBP; NFIC; SMARCE1; E2F5; SMARCA5; NFATC3; TEAD1; BATF3; HIRA; TCF25; RCOR1; CBX6; ATF4; TFAM; CXXC1; CERS6; PEX2; TAF12; ZNF226; RNF111; ZFP69B; WWP1; TCF12; RBPMS; IRF6; TRIM33; DDX5; FUBP1; ZNF107; KDM5D; SIRT7; HOXC6; PMS1; ZNF160; MED4; IRX4; ZNF14; SMAD5; MEIS2; ISL1; POU2F1; ATF2; RORA; SOHLH2; BRD4; HMGXB4; ILF2; NFE2L2; ATF7IP; HOXA7; RBBP8; HDAC3; HOXA5; RNF4; EN1; MXD4; KLF6; TRIP4; SUB1; ZMYND11; CCNT1; SOX17; HIC2; MAGED1; AFF1; ZNF266; HOXB6; ZNF532; RUVBL2; ZNF222; TBX3; RSF1; NFIX; IRF1; TRIM28; SMAD1; ZNF611; NFE2L3; SMARCB1; SMARCA1; CREB1; PITX2; ETS2; RFXANK; BTG1; ZNF432; ID1; CCNA2; FOXC1; ZNF264; MXI1; FOXK2; ZNF529; AR; DEK; ELF3; NAB1; FOXM1; CLOCK; MEOX2; YBX3; ZBTB38; DNMT3B; INSM1; HTATIP2; GTF3A; PBX3; PURA; GTF2A2; HOXC10; ZBED2; CENPF; DACH1; ARNT2; ID3; CBFB; OSR2; EYA1; BBX; STAT3; TP63; RXRA; TFEC; MYBL1; SMAD3; TSC22D1; ATF3; SOX4; CITED2