Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID70337	Mek1-2-inhibitor	GSE92742	ASC	Human	24h	10uM	EID0381

Response Information :

Types	Number	Response transcription factors
Up-regulation	180	IRF9; JUN; TGFB1; MYCL; DAXX; CDK9; HOXB13; ZNF354A; ZNF12; KDM5C; ELF4; HMGA1; ZSCAN16; SUPT3H; ZHX2; HR; FOXF1; IRF6; ZNF768; MBD1; FOXF2; BHLHE41; JUP; PBX2; ARL2BP; GRHL2; NR4A3; UBE2L3; TBX3; CBX4; NR2F1; IRX4; TCF21; HMGA2; NR4A2; ERF; PHF1; ZNF215; TRPS1; HSF1; CCNE1; FOXA1; JAK2; MED15; CREM; BCL11A; MEOX1; SSBP3; TRIM29; ZNF174; SMARCB1; ZSCAN31; CREB3; SPDEF; TULP3; TBX21; NAB2; FOXJ2; ZNF165; ZNF423; WWP1; TEAD3; PPP1R13L; CUX2; ZNF184; TDP2; ZNF34; KLF3; SUPT5H; BNC1; NFE2L2; KDM5A; CNOT3; CREBL2; ATOH1; CDC5L; ZNF331; MED17; NHLH1; E4F1; BRD7; ZNF74; HIRA; ING4; CTBP2; PRDM12; TGIF2; ZFHX3; NR1H4; IL16; CEBPG; ZNF350; FOXM1; STAT4; PHIP; HIC2; HLX; TOX3; LEF1; RXRG; SOHLH2; RNF138; MYBL1; CIR1; BARX1; PRDM1; MEIS2; TP63; NFATC1; CCNH; DLX2; JUND; TSC22D1; FOXE1; ABT1; IRF7; TFAP2C; TCF7L1; E2F3; SMAD7; NR4A1; CAMTA1; ZNF536; NR5A2; WNT4; DNMT1; SP100; KLF13; ZNF32; TRIB3; ETS1; ZNF573; RAD21; HOXC10; EHF; PRDM2; HHEX; ZNF239; NR3C2; TFAP2A; VGLL1; PBX3; PSMC3; THAP7; GMNN; SNAI2; ZNF91; ZNF180; PEG3; ATF3; CBFA2T3; NPM1; HOXB5; ID4; NEUROD1; MAZ; SKI; ZEB1; CDK2; HOXB2; NKX2-1; ZFP36L1; ESR1; ERBB4; ZFPM2; IRF8; GATA6; WT1; OSR2; DACH1; RBL2; BCL11B; ARNT2; ZFP36L2; INSM1; SATB1; ID3; EGR2; TXNIP; THAP11
Down-regulation	186	GTF2A2; SCAND1; FOSL1; SALL1; TP53; BRD8; PRRX1; TCF12; PHF20; LPIN2; BATF3; ZNF672; MSX1; TBL1X; ZNF23; TBP; ZNF160; SUV39H1; BLM; MYCBP; CEBPD; RUVBL2; PHF8; CRK; PLAGL2; NCOA6; SATB2; NFKBIA; TSG101; VEZF1; E2F5; CCNA2; ZMYM2; YBX1; TRIM32; SERTAD2; SREBF1; RBPMS; NCOA4; PMS1; ZNF721; TLE1; KDM5D; MDM2; RXRA; SMAD1; LZTS1; HMGN3; TGS1; RUNX3; ATF1; RBM14; UIMC1; SAFB2; HEY2; TAF1D; PDLIM1; MAGED1; ZNF226; MGA; TBPL1; ZNF783; CENPF; HDAC2; STAT3; PHOX2B; PRPF6; ATF4; PRRX2; ZNF528; RBBP7; HDAC6; ZKSCAN1; NUP62; TOB1; ZEB2; PRKDC; PEX2; ZNF266; FOXJ3; SAP18; EED; MTA1; SND1; RNF14; ZBTB11; ZNF224; ATF6; TSC22D4; ENO1; ZFP64; KAT5; RNF111; ASH2L; HIPK3; MYC; MED24; EDF1; CITED2; NEDD8; ACTL6A; DPF2; TCERG1; HLTF; HDAC4; KAT7; NRIP1; XBP1; MECOM; DRAP1; MTF1; BAZ1A; ERBB2; MAFB; ZNF611; UBP1; TCEA2; SMARCE1; SSBP2; ZNF146; ELF1; CTR9; NFIC; REST; TRRAP; ZNF432; BTAF1; CTNNB1; ZNF587; TRIP6; KLF6; SIX2; EZH2; ADNP; SMAD2; PMF1; NCOR2; DNMT3B; TWIST1; BCLAF1; NAB1; GTF2IRD1; TMF1; ING3; KAT6B; RHOA; MED13; EYA2; PIAS3; NLK; FLNA; MED1; SPEN; ZMIZ1; ZMYND8; PIR; STAT5A; RBBP5; JARID2; BMI1; CEBPZ; DDX5; SMAD5; FOXO1; TCFL5; EGR1; AFF1; TRIM16; BHLHE40; MEF2A; YWHAB; EMX2; TAF10; KDM2A; SIX1; SMARCD3; DMTF1; PURA; ZNF512B; ID2; ELK3; PCGF2; RFX5; SMARCA2; HOXC6; STAT5B