Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID24994 Osimertinib GSE70138 SKL Human 24h 0.04uM EID0062
Types Number Response transcription factors
Up-regulation 36 HOXA5; CARHSP1; TOX3; KAT6B; JARID2; NR2F1; BASP1; KLF4; SP110; HIRA; TRIM22; PEG3; ZNF329; RBM39; STAT1; CBFB; ZBED2; RBPJ; CNBP; IRF7; PSIP1; MYCN; INSM1; ZIC1; ATF5; VGLL4; PFDN5; PDLIM1; NR2F2; WWTR1; NFATC3; HOXB2; PBX1; MAFB; PUF60; CRK
Down-regulation 61 RXRA; MECP2; MKL2; NKX3-1; FLI1; ELF3; TP63; RBBP8; ZBTB16; TERF2; TWIST1; TCF20; FOXI1; LEF1; CBX7; HOXA11; BLM; KDM5D; SMARCA2; MAGED1; ZBTB20; ZFP36L2; RARA; KLF2; SOX13; MECOM; IRF4; NFX1; ZNF22; TTF2; ZNF331; NPAT; ELF5; HLX; HLF; PLAGL2; LPIN2; HMGB3; LHX3; ZNF552; NR1D2; ELF4; MYT1L; WNT4; GATA3; FOXA2; MYBL1; ZBTB18; DLX5; SSX1; ZNF124; KLF13; GATA2; TCFL5; RELB; MYB; E2F2; NKX2-1; SOX17; MTF2; ZNF586