Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID24727 Mitoxantrone GSE70138 SKL Human 24h 10uM EID0061
Types Number Response transcription factors
Up-regulation 341 FOSL1; CEBPA; CCNA2; NR3C2; KDM5B; CD3D; ZNF440; STAT4; NKX2-1; NR6A1; SSBP3; ZNF10; MNDA; ZNF132; ZNF701; PRDM13; HOXB5; NR2E1; ACTL6B; TULP2; EGR4; NFKBIB; ZFHX3; SOX17; HMGA1; GRHL2; TBX19; HAND1; CHD2; PRDM9; TCF7; ZNF710; DCC; CIITA; IKZF2; MAPK8IP1; VENTX; ZNF835; ZNF507; POU2F3; SRY; MAK; MKL1; TAL1; MED25; ZNF180; IRF6; RFX3; SIX6; TBX2; HOXA2; ZFP2; FOXF2; ZNF75D; BHLHE41; ZNF136; FOXM1; ZNF264; ASCL3; GATA1; TCF21; PHOX2B; PRDM10; POU6F2; CNOT3; ESRRG; SCAI; TBX21; CDX1; ZNF471; TOX4; HOXC11; HMGXB3; MAML3; ZNF225; HOXD9; FOS; ZNF814; TAF7L; ZNF235; FOXE3; ID1; ZNF780B; ZNF551; GCM2; EN2; HOXC5; KDM5C; IKZF3; FOXE1; ZNF674; POU1F1; PTTG1; SOX14; ZNF345; POU2AF1; HDAC11; ZNF493; PHOX2A; ZNF506; ZNF154; CARF; TFDP3; ZNF529; SHOX; PAX4; GFI1; DOT1L; ARID1A; AFF2; ZNF157; ZNF224; OVOL2; ZNF214; MEIS2; ZNF550; VGLL1; SMARCA4; VHL; MED15; TOX; ZNF254; ZNF215; ZNF407; ZNF80; RFX1; NKX2-5; ZNF536; TAF1C; RAD21; SOX3; ZNF334; TFCP2L1; MZF1; SOX18; HOXD11; ZSCAN32; SPEN; ZNF749; ING4; ZNF223; ATN1; ZNF273; ZNF195; THRB; CBX7; SIX3; YBX2; ZNF611; ZNF695; CHD8; ZXDB; ZNF350; ZNF557; MXD1; ETV3; ZNF81; HOXD13; PGR; HNF4A; PLAGL1; SPDEF; ATOH1; MED31; POU4F2; SNAPC4; HESX1; TFAP2A; NHLH1; SSX7; SSX1; FOXB1; THAP10; ZNF266; FEZF2; SP4; MLXIP; MXD3; ASCL2; FOXJ1; CBFA2T3; SOX15; ARID3B; NR5A2; GFI1B; SOX1; FOXF1; ZNF492; CBX4; BCL11B; HNF1A; PTRF; HNF1B; EMX1; TP73; TAF4B; ZNF117; HIVEP1; SCRT1; NR2F1; KMT2B; PRDM1; HNF4G; LITAF; FOXH1; NR0B1; CBFA2T2; SOX21; INSM1; E2F4; GCFC2; ESR1; ZBTB3; KLF7; PRDM14; FOXA2; PROX1; ZNF528; REL; ZNF426; LHX6; TRIM33; KLF13; PDLIM1; PPP1R13L; KLF1; CAMTA1; SKIL; TFAP2C; NEUROG2; UIMC1; LMO1; ZSCAN31; ZNF816; ZNF219; ST18; SHOX2; FOXI1; HOXB13; SRCAP; HOXB6; OVOL1; ZNF682; LHX3; ZIC3; RFX5; FOSB; ZNF394; CDK2; GTF2F1; CDX2; MEIS1; AR; MYBL1; NR4A1; IRF1; PSIP1; POU3F2; ARID3A; HIPK2; ZBED2; ISL1; BCL11A; WNT4; NR1I2; PAX9; HDAC9; CITED1; MYBL2; HHEX; PRDM12; EGR2; PAX5; ZNF467; ZNF44; DMRT1; GATA2; FOXA1; SOX13; HOXD1; NKX2-2; MYCL; KLF4; ZNF652; AEBP1; JUP; DNMT1; DLX5; ZNF200; HOXC4; DACH1; TLE4; ARNT2; TWIST1; PRDM2; EHF; MAFF; PSMC3; ZNF107; SOHLH2; ZNF74; TLE2; ZNF580; DLX2; TGFB1; VDR; TTF2; PHIP; CARHSP1; CRYM; SALL1; NANOG; HIRA; EYA2; POLR3C; PAX6; MECOM; MED21; ZNF165; LIN28A; LEF1; PBX1; GMNN; NFE2L3; SOX2; ATF3; CREB3L2; ETS1; FOXG1; WT1; SNAI2; ETS2; NFE2; MSX1; TP63; HIC2; ASCL1; BASP1; ID4; IKZF1; E2F2
Down-regulation 148 ATF1; MYC; NUP62; SOX4; FOXO3; RBBP4; BHLHE40; NRIP1; NFKBIA; SIX1; FOXJ3; NFE2L1; NFIL3; TCF12; CDK7; ZNF84; E2F3; PATZ1; MEF2A; ATF4; USP22; THAP11; MEF2C; ZNF148; GTF3A; RLF; NCOA1; ZBTB18; TSC22D4; MAGED1; BRD3; TEAD1; EDF1; ERBB2; TSC22D3; HMGA2; ZNF22; FOXO1; TRIM32; MED13; DEK; IKBKAP; RUNX1; CLOCK; ASH2L; NRBF2; DDX5; TAF9; BRD8; ZBTB11; ZZZ3; KDM2A; LPIN2; DPF2; NR1D2; PCGF2; WWTR1; VEZF1; ADNP; TBP; BIRC2; APEX1; CHD9; SIRT2; ZNF189; ZMYM2; COPS2; TBL1X; HMBOX1; ZMYND8; PBRM1; MNAT1; ING3; NCOR2; ZIC1; NR2C1; MLX; SETD3; HOXC6; SMARCE1; SMARCD3; MNT; JARID2; MAFG; PURA; HNRNPD; AFF1; CUX1; PSPC1; HIPK3; ZBTB1; CDYL; BMI1; RBL2; MED1; UBE2B; PMS1; CSDE1; NFIB; PITX2; YAP1; PKNOX2; SCAND1; CBX3; HOXA5; NFYC; ZFP36L1; HES1; HMG20A; ENO1; HSBP1; KAT7; KLF2; TGIF1; RNF6; SMAD1; RBBP8; NAB1; CHD1; SP3; HDAC1; TAF1D; HMGN3; FOXO4; DDIT3; DNAJC1; RBPJ; SMAD2; ZBTB16; ETV5; CEBPZ; VGLL4; SOX9; SMARCA2; HOXC10; TRIP6; ELK3; TCF4; NFAT5; MAF; FOXD1; SAP30; NR2F2; IRX5; CRK; ECD; MAFB; NR3C1