Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID24342 Gsk-1059615 GSE70138 NPC Human 24h 10uM EID0052
Types Number Response transcription factors
Up-regulation 383 FOXO4; TP53; ZNF484; FEZF2; THRB; HBP1; CALCOCO1; CHD2; VENTX; MAML3; NR5A1; TAF1C; ZNF154; SCAI; ZNF83; NPAS1; NFATC4; FOXB1; ING4; HOXA5; TCEA2; TULP1; SCRT1; ZNF362; PDX1; TBR1; PPARA; ZNF471; POU6F2; SIX6; POU4F3; SOX18; PRDM2; POU1F1; DOT1L; PRDM14; ZNF506; ZNF157; ZNF225; FOXH1; SKIL; PRDM9; ZNF814; ZNF343; MZF1; CRX; HESX1; NR1I3; HOXB8; PRDM12; MAFF; ZNF507; ZNF674; ZFY; ZNF345; ZNF350; MLLT1; PAX4; ZIC4; ZNF155; ZNF835; RFX1; LHX2; HSF4; GCM2; ZNF80; ETV2; ZNF780B; NEUROG1; SOX14; SIX5; ATOH1; ZNF749; ZNF407; ZNF81; VHL; TULP2; BARX1; GRIP1; FOXD3; ZXDB; EZH1; ZNF440; ZBTB3; FOXE3; JUP; MSX2; ZNF549; CARF; HOXB1; ZNF701; ZNF41; ZNF234; SOX30; POU2F3; PPP1R13L; ALX3; MYF5; ZNF391; LBX1; RXRG; NEUROD2; HOXA6; ZNF257; ZNF214; FOXL1; NFKB2; TLX3; HOXD12; ASCL2; ZNF493; EMX1; MEF2D; PAX3; TP73; ZNF254; CIITA; ZIM2; BNC1; ZNF334; NEUROG2; PKNOX2; ZNF613; NRL; THAP9; ZBTB7C; NANOG; RARG; ZNF132; ETV3; MNDA; ZNF695; ZNF500; FOXA2; HIPK2; PNRC1; CDX4; GSC2; GATA3; IKZF3; TEF; ZNF623; SPI1; HOXA2; MYEF2; SOX21; ZHX2; ONECUT1; FOXO3; LDB1; HIC1; ZNF224; TBX1; ZIC3; ZNF665; MXI1; ZNF112; ZNF75D; NEUROD6; DCC; LHX3; HNF4G; HOXD13; SOX3; SPDEF; NFIX; GATA1; POU4F2; HOXD1; ZNF219; ARHGAP35; SRY; ZNF778; AFF2; MED14; ZNF135; EN1; MYT1; ATN1; ZNF358; MBD4; CRTC1; CBX7; PAX1; HSF1; ZNF787; TAF4B; NCOA2; KAT2A; CAMTA1; CSDC2; DYRK1B; OLIG2; NR2E1; TRIM33; GCM1; HMX1; TBX21; HEY2; ZNF675; ZNF492; L3MBTL1; JUN; SOX17; ZNF529; ZNF432; E2F2; ZNF444; TFAP2C; FOS; CAMTA2; EVX1; CSDE1; TSHZ2; ZNF74; ZNF682; MAK; CBX4; NHLH2; ELK4; HOXB5; EN2; MYRF; PGR; SOX13; BTF3; EPAS1; ZNF215; ZNF264; LIN28A; ACTL6B; HDAC5; BCL11A; PHF1; ZNF354A; BACH2; ZNF177; ZFP2; ZNF528; VGLL1; ZNF331; ZNF136; CDX2; ZNF667; ZXDC; TERF1; HR; MDM4; BTG1; CIR1; ZNF141; ELF4; TCF25; BCL11B; IRF1; ZFP69B; HIPK1; NR5A2; NR0B2; THRA; SP140; ZNF573; NR1I2; TXNIP; SALL2; ZFP36L1; ARNT2; MXD1; ZNF544; IRX4; KAT2B; TFCP2L1; INSM1; HLF; REL; TP63; MEIS2; PHOX2B; WNT4; NKX3-2; BRD2; CREBL2; KLF1; ZBTB20; SP100; TRIM22; ZNF91; ZNF227; RORA; RAD21; ESR1; ZNF117; HOXB13; TAL1; BRWD1; NEUROD1; GFI1B; ZFP36L2; KDM4C; ZNF44; RBFOX2; TFAP2A; ELF5; PBXIP1; ZIC1; IRF6; CAPN15; ZNF580; SP110; ST18; CALR; TSC22D3; BRD4; SMARCA2; TCF7L1; ETS1; PEG3; TCF7; CEBPB; TGFB1; IL16; MAFB; ZNF611; CCNC; DDIT3; MYBL1; ZNF93; PAWR; ERBB4; BHLHE41; SNAI2; SOX10; NPAS2; FOXE1; SHOX2; FLI1; SOX11; TRIB3; LITAF; TWIST1; YBX3; ZNF266; FOXF2; NFAT5; EMX2; TDP2; IRF9; ZNF721; JUNB; ZNF589; BIRC2; CRYM; DLX5; NKX2-2; ZNF148; TCF7L2; SATB1; TRPS1; TLE2; FOSB; POU2AF1; ID2; HDAC9; SPIB; ZNF160; LOXL2; PDLIM1; EHF; INSR; ZNF423; PAX5; TRIM29; TLE4; OSR2; RUNX3; NR4A2; EGR3; TLE1; GATA6; IFI16; CEBPD; PSIP1; NR1H2
Down-regulation 80 HMGA2; SMARCC1; GTF2A2; XBP1; EED; MYBL2; SUV39H1; EZH2; RBM14; ZNF672; RHOA; HNRNPD; WHSC1; SETD3; PLAGL2; BMI1; PARP1; BRCA1; VEZF1; BLM; EDF1; RAN; SFMBT1; SMARCA5; ING2; ASH2L; PIR; UBE2L3; FHL2; HSF2; CRY1; DR1; DNAJC1; BRD3; MAGED1; SIAH2; TRIM32; PSMC3IP; BAZ1B; ACTL6A; HOXC6; NR2F2; ENO1; YEATS4; C1QBP; CCNA2; TRRAP; E2F6; MGA; ZNF410; HMGB3; HOXC10; RBBP8; SIX1; BATF3; BAZ1A; SAP30; YWHAB; SCAND1; NPAT; CBFB; NAB1; ZNF22; TRIM16; MYCBP; NCOA1; MSX1; CBX6; ZNF131; NRIP1; IRX5; RBBP4; IKBKAP; TBL1X; TCF4; ZEB2; ZBED1; MYB; DACH1; NFATC3