Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID24262 Mitoxantrone GSE70138 NPC Human 24h 10uM EID0052
Types Number Response transcription factors
Up-regulation 393 NFATC4; ADRB2; EMX2; THRB; PAX8; ZNF154; MAML3; EMX1; IRF6; ZNF350; PRDM9; NFKBIB; MEF2C; HNF4G; ATOH1; CHD2; MYBL1; FEZF2; FOXB1; CCNH; HSF1; SCRT1; RFX1; ZNF155; ZNF814; TP73; DOT1L; ZNF695; SOX18; VENTX; ETV2; POU4F3; POU6F1; BARX1; NR5A1; HIPK2; ZNF471; PRDM14; TFAP2A; PAX4; ZNF132; POU6F2; SOX14; LBX1; FOXD3; NR1I3; FOXE3; ZNF816; NEUROG2; ZNF407; ZNF549; ZNF674; IRF1; TAF1C; TEF; ZNF157; ZNF749; SATB2; DLX4; ZNF41; GCM2; ZNF80; NFE2L3; TBR1; ZNF550; NEUROG1; ZNF141; ZNF391; ZNF343; MECOM; RORC; KLF8; HOXD12; ZNF81; PDX1; FOS; ZNF225; PRDM16; TLX3; ZNF780B; GBX2; CEBPZ; ZNF682; ZNF362; SPDEF; FOXH1; CRX; RBPJL; PPARA; ASCL3; ALX4; ZIC4; HESX1; ZNF215; MLLT1; NFKB2; CARF; SSBP3; ELF3; NR6A1; ZNF257; TFDP3; FOXN1; TGFB1; ASCL2; TULP2; SSX7; TULP1; NFE2L2; SCAI; POU1F1; ZNF701; FOXA2; HES2; IKZF3; TAF4B; NPAS1; VHL; MSX2; UTF1; ZNF214; KLF3; NEUROD2; POLR3C; PCBD1; SOX13; POU2F3; GSC2; ZXDB; THAP9; GRIP1; AIRE; CNOT3; ZNF235; JUP; TCEA1; RARG; TBX1; RFX3; SIX5; ETV3; SOX21; ZNF208; OVOL1; ZNF442; NR1H4; MYNN; BNC1; ZNF507; HOXD9; GATA1; PROP1; BRDT; TDP2; TBX4; ZIC3; WHSC1L1; ZBTB7C; MAK; PSMC3; REL; ZNF440; ZFY; NANOG; CDX4; SIX6; HDAC9; VDR; HOXA2; NACA2; ZKSCAN8; ZNF234; HIC1; ZNF75D; ZNF544; LIN28A; ZNF480; PRDM13; NRL; SKIL; FOXC2; POU3F3; HMGA1; PRDM10; ZNF613; TONSL; HOXB8; ZNF675; NR0B2; HIF3A; ZNF239; FOXL1; ZNF771; ONECUT1; TLX2; EHF; HOXA6; ZNF586; PRDM12; ATF3; TBX10; TFCP2L1; KLF1; PAX1; MNDA; SHOX; PHOX2B; TBX5; FOXI1; ZBTB3; ZNF835; CDX2; DMRT1; SRCAP; ELF4; ZNF180; ZNF135; NEUROD6; ZNF254; MAFF; EPAS1; SOX17; ZNF195; HOXB1; ZNF415; CDX1; HOXA5; ESRRG; MYEF2; HOXD1; NR5A2; ZNF345; NFIX; CBX4; ZFP2; SIM1; ZNF165; TAF7L; ZNF83; ZNF304; ZNF33B; JAK2; SUPT3H; SUPT5H; CALR; CREB3; DAXX; SLC2A4RG; SRY; L3MBTL1; KLF6; HOXB5; GFI1B; ZNF623; FHL5; STAT6; ZNF665; NOC2L; JUN; ZFP69B; ARNT2; TSHZ2; ZNF492; TDRD3; ERBB4; LHX3; GCFC2; TCF21; PAWR; SOX12; HOXD3; OVOL2; BCL11A; NFE2; ZNF606; TLE2; SREBF2; ZNF671; DDIT3; ZBTB7A; CRYM; VGLL1; ZFP36L1; ZNF175; EVX1; LITAF; GTF3A; AES; ZNF264; TRIB3; COPS5; HOXB13; CDIP1; EGR4; NPAS2; HIVEP1; HBP1; STAT4; POU5F1B; EN1; FOXF2; TEAD4; SOX3; PEX2; CBFA2T3; HOXB2; PITX1; ZNF557; BRWD1; NR1I2; FOXF1; CREBL2; POU4F2; HEY2; TWIST1; ELK4; ZHX2; ZNF331; SHOX2; NKX3-2; LHX2; ZBED2; TAL1; SP140; ZNF426; TFDP2; ZNF224; NEUROD1; HAND1; NCOA2; ZFPM2; IRF8; SAP18; CBX7; ZNF273; TFEC; KLF4; ZNF593; SMAD7; CEBPG; MXI1; LOXL2; FOSB; ZNF467; ZNF551; SNAI2; NR4A3; HLF; KDM4C; CEBPB; HIRA; IRF9; ZNF423; FOXJ1; ZNF91; E2F5; ZNF117; NR3C2; MYRF; OLIG2; ZNF217; CUX2; TSC22D3; FOSL2; RORA; YBX3; TRPS1; BHLHE41; PDLIM1; ESR1; ST18; ZNF394; KAT2B; KLF5; ZSCAN18; SOX9; ELF5; PEG3; CEBPD; KLF2; CREM; ZEB1; HOXB6; OSR2; MEIS2; CITED2; GATA2; GATA6; WT1; ID1; E2F2; NR1H2; PSIP1
Down-regulation 178 NUP62; SOX4; SPEN; EZH2; SUV39H1; BRD8; USP22; CENPF; BMI1; NRIP1; PBRM1; ATF1; HNRNPD; NR2F2; EGR1; MAGED1; JARID2; EED; PCGF2; SETD2; BRD3; KDM5B; WHSC1; SOX2; MTF2; NR1D2; CTR9; NCOA6; ECD; CITED1; PHF2; MLXIP; CHD7; RHOA; HDAC6; TRIM32; PATZ1; NEDD8; THAP11; ATF7IP; TBP; ARID4B; BCLAF1; MED1; HLTF; HSF2; MGA; ZBTB40; DDX5; RNF4; AFF1; ERBB2; ZNF146; TBL1X; ZNF248; VEZF1; FOXJ3; ING3; TRRAP; ADNP; CBX5; TCF12; CRY1; CHD9; USF2; BAZ2B; PTTG1; SMARCE1; SFPQ; BLM; ZNF410; RBM14; EWSR1; SREBF1; ZNF302; SUZ12; PURA; ZNF84; ZNF24; RYBP; ASCL1; HMG20A; TCF4; MED6; ZBTB14; CCNA2; SIX1; NPAT; MYBL2; RFX5; MAML1; NCOA1; HES1; MSX1; KAT8; MED24; BASP1; ZMYND11; KAT6A; NFIC; HOXC6; ZNF189; RBBP4; ITGB3BP; IRF4; ZNF629; NCOA4; ZBTB18; TULP4; ZNF148; CREBZF; FHL2; BRPF1; KMT2A; SIAH2; GLI3; USP21; ZBTB1; SOX11; CHD8; NCOR2; BBX; POLR2A; PIAS3; RBBP7; E2F6; SMAD5; ZEB2; CLOCK; DNAJC1; CNOT6; ETV5; KAT7; ZMIZ1; MAFG; VGLL4; RERE; HMGB3; REPIN1; PSMC3IP; PHF20; UBE2I; HMGN3; MED13; ZBED1; BATF; SMARCD3; EGR2; ID2; RUNX1; PIR; CHD4; ID4; ZBTB38; MYB; IL16; PIAS1; FOXO1; CTBP2; ABL1; AEBP1; SCAND1; DNMT3B; HMG20B; NKX3-1; TCFL5; TBX3; EYA1; LEF1; MAFB; MYCN; EGR3; ZMYND8; FOXC1; PBX1; TLE1; PBX3; NFATC3