Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID23982 Bosutinib GSE70138 NPC.CAS9 Human 24h 10uM EID0056
Types Number Response transcription factors
Up-regulation 394 MYC; NR1H2; FOS; NFIL3; EN1; TSC22D3; NFKBIA; PCGF1; JUN; HES1; TBR1; FOXJ2; VENTX; CEBPG; EMX1; PDLIM1; FOXO4; ELF4; SOX18; SCRT1; CHD2; THRB; ZNF174; VDR; FOXL1; CBX4; ZNF222; CEBPD; HNF4G; FOXH1; RBPJL; ZNF576; NRL; MYNN; ZNF593; TULP1; NEUROG3; ZNF668; TP73; FEZF2; PRDM9; NFKB2; ZBTB3; ZNF549; NR5A1; PAX3; FOXD3; ATF3; ZNF235; HOXB5; CBX8; FOXB1; IRF6; ZNF154; POU4F3; ZNF391; PAX4; LHX3; HSF1; ZNF550; ZNF214; PDX1; ZNF580; NFE2L2; ZNF221; HOXB1; SSX7; ZNF749; ZXDB; NFATC4; SRY; ZNF324; SPI1; ZNF780B; TLX3; FOXC2; SOX13; BRDT; POU1F1; ALX3; IRF1; ZNF787; DOT1L; MAML3; TULP2; HOXB8; ZNF623; ZNF362; BARX1; HOXD13; ARNT2; ZNF225; ZNF304; FOSL1; ETV2; SNAI2; ZNF343; TFDP3; GRIP1; POU6F2; SIX6; TEF; ELK4; PNRC1; NEUROD2; RARA; KLF3; PRDM14; ZNF81; SRCAP; HOXD12; MLLT1; TSHZ2; SSX3; CBX7; MEF2D; HES2; GCM1; ZNF674; UTF1; ZNF80; CEBPB; SP4; VGLL1; GSC2; ETV3; HIC1; SOX14; E2F4; GCM2; BCL3; TFAP2A; ZNF442; CDX4; CAMTA2; LBX1; NFKBIB; ZNF574; IKZF1; ZNF132; ZNF557; TAF6L; SCAND1; MKL1; NKX3-1; NEUROG2; NKRF; ZKSCAN4; POU2F3; KLF1; EGR1; ZNF34; ETV6; BRD4; ZNF407; ZNF35; SERTAD2; ZNF175; PRDM13; GBX1; TBX1; RORC; CCNH; TAF4B; JUNB; BHLHE41; TONSL; ZNF695; ZNF688; SKIL; PIAS4; ASCL2; PPARA; GATA1; IRF9; RXRG; THAP7; MAFG; HESX1; POU4F2; OVOL2; SIRT7; NEUROG1; STAT4; ZBTB43; TEAD4; ZNF384; FOXE1; ZNF350; VPS72; CDIP1; CEBPA; DDIT3; MAK; SOX21; MAFB; BNC1; ALX4; ZBTB7A; KLF13; HLX; BRF2; TDP2; SRF; SOX9; ABT1; ZNF180; ZNF215; ZFP36L2; ZNF835; KAT2A; ZNF263; SNIP1; ACTL6B; NRBF2; BCL11A; IRF7; ZSCAN31; NOCT; PIR; SOX10; HMX1; ZSCAN9; ASH1L; ID3; TP63; ZNF264; BTG1; FOXF2; PRDM8; IKZF3; HDAC5; MLX; TRIM33; LHX2; EHF; ZNF211; KLF11; THAP11; PHF1; MSC; ZNF354A; HBP1; HOXB2; ZXDC; IRF8; INSM1; ACTL6A; ELF5; CBX6; TAF5L; NR1H4; ZNF816; ZNF267; SSBP3; FOXA2; NFE2L3; FOSB; HDAC9; SPDEF; CREB3; TGFB1; ZHX2; ZBED2; TOPORS; RARG; HLF; NHLH1; HHEX; ID2; HOXD11; ZNF331; BRD2; SP100; ZNF239; NEUROD1; MNT; ERF; MXI1; ZNF165; ATF4; SUPT4H1; UBTF; HOXD1; DLX4; PITX1; OVOL1; ATN1; ZNF654; ZNF394; RNF6; PRDM2; C1D; HEY1; WNT4; RELA; ID1; CEBPE; SSBP2; ST18; CUX2; CRYM; PPP1R13L; MBD2; TGS1; ZNF552; FOXD1; MXD1; CNOT3; MAFF; RYBP; FOXA1; RORA; E2F8; HDAC4; ARID5A; HIVEP1; PTRF; TFAP2C; MED17; CENPB; ZNF671; SP140; HOXB13; ZNF467; TAF1; MNX1; ZNF134; LITAF; SSX1; HOXB6; ANKRD1; RLF; TRIM29; CERS4; ZNF224; GRHL2; MITF; PEX2; TOB1; SNAPC4; GATA6; POU2AF1; HOXB7; JUP; ZFP36L1; DLX5; TRIM16; ARNTL; FOSL2; TFEC; WWC1; DAXX; TRIB3; HOXA5; SMAD7; SPIB; ZNF551; NR1H3; YBX3; CREBL2; FOXG1; MYRF; ERBB4; VGLL4; AHR; NR4A2; TCF21; COPS5; ERG; ARID5B; CREB3L1; NFE2; ELF3; ZNF281; MNDA; ATF5; EGR2; EPAS1; REL; KLF2; SMARCA2; CREM; WT1; TCF7L1; TWIST1; TBX3; MEIS2; RUNX3; OSR2; KLF4; ZNF586; RELB; MEF2C
Down-regulation 173 EZH2; HMGA2; SMARCC1; SMARCA4; PARP1; HDAC2; BCLAF1; BRCA1; ETV1; RBBP4; SMARCA5; MYBL2; TCERG1; CDK2; HDAC6; ZMIZ1; ERBB2; CBX5; TRRAP; BLM; PRKDC; RUVBL1; CNOT1; SFPQ; ELF2; MAGED1; EWSR1; CHD9; DEK; RB1; SREBF2; ZEB2; CBX3; CENPF; MYCBP; EP400; TULP4; MGA; TCF12; NCOA1; PUF60; HNRNPD; NCOR1; CNOT2; ZNF248; PBRM1; ZMYND11; ECD; ATF1; HMGN3; ZNF85; ZNF516; RERE; PMS1; KAT6B; ENO1; WHSC1; HSF2; MTA1; HMGB3; PHF20; CCNC; SMARCE1; REST; BAZ2B; ORC2; TLE4; SMARCC2; HMG20A; TRIM24; CHD1; HMGB1; DNMT3B; RNF14; TBL1X; FOXJ3; MEIS1; BMI1; BPTF; NEDD8; CBFB; BRIP1; BRD3; TCF4; CTNNB1; CHD7; SMAD2; HMBOX1; ITGB3BP; TAF9B; BAZ1A; HDAC1; YWHAB; SOX11; MNAT1; CDYL; TSC22D2; XRCC6; URI1; LEF1; NPAT; RCOR1; DDX5; NONO; MED24; ZNF302; RBM14; TP53; SND1; MED13; HSBP1; ZNF43; CERS6; SLC2A4RG; CARHSP1; LOXL2; GTF2I; NPM1; ZNF146; HMGB2; NCOR2; ASH2L; MLLT10; ZNF160; MED1; MSX1; PAXBP1; ZNF721; LPIN2; JARID2; TRIM32; DMTF1; HOXC6; TCF25; ZEB1; DNAJC1; PLAGL1; RUVBL2; CTBP2; GTF2IRD1; RBL2; PBX3; STAT3; PCGF2; ZMYND8; RBPJ; NR2C1; HLTF; ELK3; IKBKAP; E2F3; PBX1; RBBP8; NRIP1; ZMYM2; BASP1; NCOA6; WWTR1; AEBP1; ETS2; ZBTB38; DACH1; RUNX1; MYCN; HTATIP2; NR2F2; IFI16; TXNIP; TRIM22; ASCL1; NR2F1; RBPMS; NFATC3