Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID23450	Osimertinib	GSE70138	NEU	Human	24h	0.37uM	EID0049

Response Information :

Types	Number	Response transcription factors
Up-regulation	101	DAXX; NFYA; ZSCAN31; NFE2; MBD4; ZIC3; ZNF264; RUNX1; NKX2-2; ZNF165; CBFA2T3; ZNF573; PLAGL1; ST18; HDAC5; HOXB5; ZBED1; CREB3L2; LITAF; HOXB2; LYL1; HOXB6; FOXI1; SMAD1; LEF1; MED15; GRHL2; ZNF410; DLX2; PGR; ZNF467; IRF3; NR5A2; ZNF331; ZKSCAN4; NR0B1; ZNF652; ECD; FOSL2; BCL11A; CAMTA2; JUNB; MECOM; INSR; KLF5; RREB1; REL; SOHLH2; ZNF623; ETS2; PLAG1; CLOCK; RAD21; HIVEP1; BACH1; TFEC; ELF4; YBX3; OSR2; CUX1; SIAH2; STAT6; UBE2B; TRIP6; TOB1; STAT1; EHF; WT1; ELF3; SCAND1; TEAD4; YAP1; PAX6; PHF20; JUP; MEOX1; HHEX; ZFP36L2; ERG; TRPS1; HOXB7; BNC1; EN1; ACTL6A; IRF6; CDK2; MYBL2; HLX; SOX17; MYBL1; CALR; NFE2L2; TSC22D1; TWIST1; ATF3; CEBPD; CCNH; ZNF394; ZBTB16; TRIM22; TRIB3
Down-regulation	81	BAZ1B; ZNF593; IRF4; FLNA; ID3; EYA2; SSBP2; NFIB; PBX1; SAFB2; LZTS1; SIX1; EYA1; MED17; KAT2B; IRF2; POLR2A; TFAM; SIX2; BPTF; PEX2; HMGB1; HLTF; DDIT3; HMG20A; ETV5; HMGB3; KDM2A; NR1D2; SMAD6; ABL1; CTBP1; ZNF532; SP110; SATB2; TRRAP; POU2AF1; MAFB; SALL1; EZH2; ISL1; TULP4; HEY2; NUP62; PSIP1; ZBTB1; ERBB2; ZBTB38; RBBP4; APEX1; SALL2; CBFB; MED1; PTTG1; TCEB2; PHOX2B; ZEB2; KAT7; KLF2; NR2F1; CITED1; BMI1; SOX9; NCOA4; BACH2; TP63; PCGF2; EDF1; TXNIP; TLE1; HDAC2; JARID2; ASCL1; KDM5A; TLE4; HMGN3; BRD3; MYCN; ID1; NFATC3; MAGED1