Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID22347 Osimertinib GSE70138 ASC Human 24h 0.37uM EID0027
Types Number Response transcription factors
Up-regulation 18 HOXA5; NFIC; BCL3; FLNA; WWC1; ARID4B; KLF11; CITED2; IKZF1; TFDP1; TRPS1; RBPMS; GLI2; ETS1; TRIM29; FOSL2; ZNF217; KDM5D
Down-regulation 22 TRRAP; ZKSCAN1; TRIB3; NR4A3; ASCL1; CTBP2; AEBP1; MYCL; ERG; POU4F1; AFF1; ZHX2; NR4A2; SSX1; KLF4; ZSCAN18; THAP11; DAXX; TOX3; TOX; ID3; DACH1