Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID21676 Osimertinib GSE70138 SKL.C Human 24h 0.04uM EID0066
Types Number Response transcription factors
Up-regulation 155 DMTF1; NEUROD1; DNMT1; FEZF2; HOXD12; NEUROG2; SOX1; MYF6; SOX18; TBX21; PRDM2; PAX9; ZBTB7C; ZNF749; ZNF81; GMNN; TAF7L; HOXD10; ZNF780B; MYEF2; POU6F2; EMX1; BRDT; ZXDC; TEF; RORB; VGLL1; MLLT1; PAX4; MAK; TULP2; RARG; GCM2; HOXD3; NACA2; JUND; LBX1; BCL11B; SOHLH2; ZNF80; ZNF214; STAT4; GCM1; SRY; POU4F3; DCC; SOX3; POU1F1; TAF1A; PITX2; PRMT2; NKX3-2; RXRG; TBX1; EN2; FOXE1; NR2E1; SIX6; ZNF492; WT1; PRDM12; ZNF682; KDM4C; SP140L; NFIX; GTF3A; HOXB2; ONECUT2; ZNF257; NFE2; MYBL2; E2F2; FOXG1; CD3D; ATF3; LZTS1; GBX2; TLE2; HOXD11; LHX2; MEIS2; CBX7; ING4; HIC2; GFI1B; IRX4; AIP; CBFA2T2; TAL1; GFI1; ZNF117; RUNX3; MYRF; SSX1; DLX5; LEF1; ZNF573; ST18; GRHL2; PGR; MEIS1; SIM2; RBM39; AEBP1; INSM1; SIX3; NR0B1; PBX1; DAXX; SHOX2; HMGA1; KAT2B; AES; CTBP2; TSC22D1; GATA6; ARNTL2; SOX17; TEAD4; ZNF217; ZNF415; ZBTB16; TFAP2C; EED; ARID5B; ZFPM2; ZKSCAN1; MYBL1; TCF4; EYA2; PHF20; NKX2-2; PAX6; CITED1; MITF; SPDEF; TGFB1; ZNF589; INSR; MXI1; TRIM16; IRF4; KLF11; HHEX; NR2F1; EHF; CREG1; ZBED2; NFE2L3; NRIP1; PDLIM1; MSX1; ZBTB18; ZNF131; ID4
Down-regulation 57 CREB1; FHL2; ING2; USP22; HMGB3; MED24; IRF5; MED1; RBBP8; STAT6; TMF1; KLF10; TFAM; CCDC59; UBE3A; ZBTB11; NFAT5; SATB2; CHD7; MEF2A; ETS2; BCL3; AGO2; ID3; RLF; TOX3; CRY1; PPARGC1A; FOXC1; BASP1; SMARCA1; TFCP2L1; MBD2; ID2; KAT6B; TCF7L2; SIX1; BBX; TOB1; BAZ1A; ZNF587; FOXD1; NR1D2; JUNB; VDR; IRX5; NCOR2; BRD2; ASCL1; SNAI2; ID1; HTATIP2; IRF6; CRYM; HEY1; BTG1; CITED2