Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID21674	Osimertinib	GSE70138	SKL.C	Human	24h	0.37uM	EID0066

Response Information :

Types	Number	Response transcription factors
Up-regulation	100	RORA; ZNF165; GATA3; IRF3; SALL2; FOXG1; ZBTB3; MEOX1; PGR; BRDT; SIN3B; SOX3; NR2E1; BLZF1; CNOT2; INSM1; ZFY; HIPK1; PRDM2; MED7; MYCN; NR1H4; GLI2; ZMIZ2; ZNF493; FOSL2; TRIM28; SKIL; PLAGL1; ID1; HDAC4; ZNF593; ARNTL2; ZNF7; HIPK3; ZSCAN16; ZNF623; CERS4; WHSC1; YEATS4; SAP130; ASXL1; HLF; TFDP2; OVOL2; THAP10; SIX3; ENY2; ELF4; TCF21; VGLL1; DLX5; BNC2; STAT4; KLF7; AGO2; MYCL; MYBL1; FOXM1; CDK2; WWP1; TP63; ISL1; CREB5; SIM1; MAFF; NR0B1; FOXO1; BRD4; TCF7L1; KDM5A; HOXB5; PAWR; BACH2; HEY2; TAL1; HHEX; PAX6; KLF6; BCL11A; CREM; WWTR1; MKL2; JUP; FOXD1; SPDEF; WT1; KDM5D; STAT6; NFE2L3; AHR; INSR; ARNT2; ASCL1; KLF5; ZBED2; PBX1; NRIP1; PDLIM1; MEIS2
Down-regulation	76	ECD; BASP1; ATF5; CHD9; BRD3; SMARCC2; NFX1; MLXIPL; TRIM32; SMARCA5; CD3D; TAF7; LEF1; SMARCE1; SP110; CTR9; SIX1; BRD8; NFYC; SNAI2; MED24; MTDH; SMAD7; EDF1; CREB3L1; ZNF131; PHIP; EED; PITX1; TGFB1I1; PURA; ZNF22; HLTF; ZNF107; ARID1A; SMAD4; BAZ1B; NFKB1; POU2AF1; MED23; TRIP6; GFI1; TDP2; ZNF12; LPIN2; FOXF2; ZIC1; ZNF43; IFI16; ZNF148; DEAF1; MED1; NPAT; MBD2; KLF4; MAGED1; SP100; BAZ1A; NR2F2; MNDA; NKX3-1; ST18; MYT1L; SMARCD3; ZNF331; ID3; FOSB; VGLL4; NR4A2; NR1D2; MAFB; SMAD1; ZNF652; IRF7; HOXC6; E2F2