Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID21663 Motesanib GSE70138 SKL.C Human 24h 0.12uM EID0066
Types Number Response transcription factors
Up-regulation 68 SUV39H1; BRD4; CTR9; EYA1; RARB; NFIC; HDAC1; PIAS3; TBL1X; NFIX; CHD4; GLI2; TRIM24; PQBP1; PBX3; BHLHE41; SP100; XRCC6; NCOA6; KLF13; MED12; DNAJC2; SOX13; CDC5L; SIX2; AIP; GTF2IRD1; HLF; PRRX1; HDGF; BNC2; MECOM; NKX3-1; MAZ; ZNF580; FOXM1; ANKRD1; NCOA1; FOXG1; TRPS1; CREB3L1; RBBP8; FOXA2; TEAD4; PLAGL1; ZBTB38; MKL2; SIX1; TCF4; TRIM29; TCF12; TP63; NCOR2; NR2F1; SPDEF; SMAD2; NR1D2; NRIP1; HMGB2; NPAS2; NR2F2; HMGA1; KLF5; PDLIM1; KDM5D; IRF6; EGR2; ZIC1
Down-regulation 49 FHL2; RBM14; BASP1; EED; E2F6; CREBZF; HMG20A; ZNF175; DR1; PURA; RUVBL2; FOXJ3; HAND1; SP110; KLF10; TRIM16; TSC22D2; ZNF146; BCL11B; ZBTB11; MEF2A; DLX2; MYCN; LEF1; ZNF532; HOXA1; ZNF131; VEZF1; PAWR; CD3D; NRBF2; BHLHE40; CDK2; KLF11; NR0B1; MYB; ELF1; PSIP1; IRF7; MYBL1; WT1; HMBOX1; HHEX; BCL11A; HTATIP2; ETS2; ZFP36L1; E2F2; NR3C1