Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID21622 Ibrutinib GSE70138 SKL.C Human 24h 0.12uM EID0066
Types Number Response transcription factors
Up-regulation 133 SUV39H1; GATA3; NR2F6; MYRF; HSF4; SOX21; FOXH1; ERBB4; RARB; HIPK2; TBL1X; ATOH1; FOXI1; STAT2; EPAS1; HIC1; ZFHX4; LIN28A; SIX6; FOXC2; DDX17; ERG; EHMT2; GLI2; MNDA; CRTC1; ZNF467; ZNF778; SIX3; EBF2; HOXD3; NFIX; HOXA5; TDP2; UBE2L3; LYL1; MDM4; CREB5; NCOA4; ANKRD1; PRMT2; PEG3; ZNF665; CREB1; NFIL3; HOXA7; ZBTB38; KLF9; GLI3; BNC2; CITED1; TCF7L1; TSG101; TSC22D4; MTA2; TEAD1; NANOG; PBRM1; RNF141; DEAF1; ARID3A; RNF10; TLE4; CTR9; THRAP3; ING3; NFAT5; ZNF721; ZEB2; CALR; THRA; EGR3; OLIG2; E2F2; CD3D; CENPB; LIMD1; GFI1; MDM2; ZNF652; TRRAP; SOX11; PROX1; HIC2; FOXF2; SAP30; RARA; MKL2; SUB1; TOX; SPDEF; SMAD6; NKX2-2; ZNF136; SND1; NR3C2; ZBTB16; ZNF611; ZNF148; BCL11B; FOXO1; MED15; ZNF22; JUNB; ZNF160; TFEC; PHF20; MAGED1; ASCL1; MEIS2; CEBPZ; TCF4; MECOM; HEY1; NR2F2; FOXG1; MAFB; ZBTB20; SIX1; NR1D2; PDLIM1; ZNF423; LITAF; RBPMS; ZNF91; SOX9; CEBPD; TOX3; DACH1; TXNIP; TRPS1; MYB; MAF
Down-regulation 50 HMGA2; BASP1; PTTG1; ZNF532; MLXIP; ATF5; ZNF45; PSMC3IP; ZMYND8; TULP3; ZBTB43; SMAD4; YBX3; MED21; CHD7; WDR77; RCOR1; LEF1; YAP1; CNBP; OSR2; MAFG; MEIS1; MYBL1; HOXA10; WNT4; TAF7; ATF7IP; E2F5; NKX2-1; FOXN3; PBX3; EHF; ZSCAN18; ELK3; HMGB3; TEAD4; TRIM24; ID1; RLF; SHOX2; INSR; ZIC1; BCL11A; WWC1; TWIST1; PAX5; SNAI2; TRIM29; ZNF586