Transcriptional response

Meta Information :

Response ID	Perturbagen	Data accession	Cell Source	Species	Duration	Concentration	Expression ID
RID21352	Osimertinib	GSE70138	SKL.C	Human	24h	3.33uM	EID0064

Response Information :

Types	Number	Response transcription factors
Up-regulation	98	ZFPM2; EGR2; TCF21; MZF1; TBX2; NFATC4; TSC22D3; CNOT3; RARB; TGFB1; ESRRG; CREB3; BNC2; EPAS1; EZH1; CEBPD; ZNF45; ELF4; NEUROD1; CBX4; ZFHX3; GATA6; SP140L; MNDA; TLE4; ZNF331; ZNF304; NFIL3; CENPB; EHF; CBX7; ERF; DDIT3; TOB1; GATA4; HDAC1; FLNA; ZNF112; TFAP2A; ID2; BHLHE41; SMAD6; ZNF266; ZNF217; FOXN3; SOHLH2; MYRF; PPARGC1A; ARNT2; ZNF83; PBX3; TRIB3; MAF; ZSCAN31; ST18; ZNF124; HBP1; CBFA2T3; EGR3; ZNF580; CBFA2T2; PITX2; NR4A3; AHR; TAL1; ZNF512B; NFE2L2; NR1H2; HIC2; KLF13; ZEB2; MAFB; NR4A2; MITF; ASCL1; ZBTB16; JUP; ZNF232; SNAI2; RREB1; TP63; ERBB4; KLF4; FOXO1; MXI1; NR1D2; FOSL2; IFI16; TOX; ZIC1; HEY1; TWIST1; ATF5; LEF1; ZNF652; KLF9; TOX3; NFATC3
Down-regulation	56	HMGA2; RHOA; FOSL1; MYC; MYCBP; PTTG1; C1QBP; EDF1; UBP1; NFKB1; HSF2; BAZ1A; SUB1; RRN3; ENY2; BCLAF1; KLF6; IRX5; EGR1; CBX3; RBPMS; MTA1; TBX3; SMAD3; PRRX2; ZNF721; E2F5; MSX1; SIX1; SPIB; SIAH2; MXD4; RAN; CTR9; RNF141; CENPF; DLX2; TCF4; SIX2; NR2F2; TADA3; FOSB; PBXIP1; ZMYND8; ELK3; BTG1; CREB1; HTATIP2; MAGED1; CITED2; HES1; HOXC6; GATA3; ID1; E2F2; SUV39H1