Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17939 Gsk-2126458 GSE70138 MCF10A Human 3h 0.12uM EID0022
Types Number Response transcription factors
Up-regulation 46 TSC22D3; HDAC6; NR3C1; ID2; RORA; FOXN3; CDK7; HMGN3; NFIL3; COPS2; MAGED1; NCOA6; MXI1; SMAD2; SOX4; PQBP1; TAF10; PPARGC1A; HBP1; ELF1; MAFB; EDF1; HOXC6; RNF6; ENO1; SAP18; TLE1; GTF3A; SAP30; NFKBIA; ERBB2; HOXA5; HSBP1; TRIM22; AFF1; IRX5; MEOX2; ELK3; CARHSP1; ARID5B; BMI1; NRIP1; SMAD1; BTG1; IRF8; CREG1
Down-regulation 137 FOSL1; MYC; EGR4; ID1; EGR1; NR4A1; JUN; WT1; NR4A3; TAF1A; SRF; WDR77; HMGA2; NFE2L3; ZNF770; POU5F1B; BCOR; KLF10; HES1; ISL1; E2F4; EGR2; NAB2; IRX4; ILF2; JUNB; SOX11; NANOG; EGR3; SOHLH2; ACTL6B; ZNF331; BNC1; ZBED2; ZNF711; FOXL2; ZNF211; MAFF; CBX6; BCL11A; ZNF529; SRY; NKX3-1; ZNF516; ZNF235; NR0B2; GRHL2; MYT1L; PROX1; ZNF10; AFF2; ZNF667; DLX5; HOXB2; LHX3; ZNF334; HIC2; FEZF2; TSC22D2; BHLHE40; EYA1; STAT4; ZNF682; TCEA2; NR4A2; SIX2; ARNT2; CHD2; SOX21; ZIC3; DLX2; ZNF835; MEIS1; KLF4; ZNF304; ID4; MED17; VGLL1; ZNF239; GLI2; NFE2; FOSB; ZFP36L1; CBFA2T3; FOXF2; TGFB1I1; NR1H4; PKNOX2; FOXF1; TCF21; PEG3; SOX5; ZNF264; ZEB1; INSM1; SOX17; SIX3; HDAC9; EYA2; VPS72; ZNF573; HMGB2; LEF1; BCL3; TFAP2C; SPDEF; SOX9; LIN28A; TRIM29; VDR; ESR1; SMARCD3; SOX2; SSBP3; KAT2B; PTTG1; HEY2; TOX3; CREB1; JAK2; GATA2; PBX1; PBX3; NFATC4; CUX2; KLF11; BHLHE41; MEF2C; DACH1; GATA6; NR1H2; ZNF589; TBX2; SSBP2; MEIS2; EMX2; IKZF1