Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17879 Canertinib GSE70138 MCF10A Human 3h 0.12uM EID0022
Types Number Response transcription factors
Up-regulation 44 TSC22D3; RAN; ID2; COPS2; ID3; HLF; TLE4; HMGN3; SALL1; NR2F2; NFE2L1; ID1; ZNF512B; MEF2A; SSX1; MKL1; BRD8; PLAGL1; MAGED1; TFEC; SMAD6; ATF4; NPM1; IFI16; HMG20A; PNRC1; CARHSP1; APEX1; EMX2; SCAND1; TRIM22; ZNF131; ERBB2; PITX1; RBBP8; JARID2; TCF4; JUP; FOXJ3; CITED2; MEIS1; CREB1; TRIP6; HOXA5
Down-regulation 46 FOSL1; MYC; HMGA2; FHL2; MAFF; EGR1; BHLHE40; SOX9; CREM; ETS1; ZNF281; EGR3; JUNB; PPARD; TSC22D1; SIM2; EGR2; XBP1; BCL10; NR2F6; CRY1; TBX3; KLF9; LITAF; ADRB2; CHD7; ASCL1; NR4A1; OLIG2; DLX2; PBX3; NR4A2; CTBP2; ZBTB18; TOX3; ZEB1; SMAD3; SNAI2; ETV1; NRIP1; DACH1; MYB; INSM1; FOS; HOXC6; ZNF331