Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17871 Afatinib GSE70138 MCF10A Human 3h 1.11uM EID0022
Types Number Response transcription factors
Up-regulation 55 TSC22D3; IKZF1; BRD4; PSPC1; CERS6; LDB1; ZMYM2; RCOR3; RBPMS; ZNF107; INSR; TRIM24; KAT2B; HMGA2; SIAH2; E2F8; ZMYND8; TOB1; ZNF423; AES; FOXO1; ZNF91; BCL6; ZNF43; MECOM; ZNF12; DACH1; CEBPB; CREB1; ZNF117; ERBB4; TLE4; MEOX2; SMAD1; TP63; TCF7L2; WNT4; PAX6; ZNF264; PNRC1; AEBP1; ZNF83; TRPS1; ATF3; ARID1A; TCF4; NR1H2; FOXJ3; TLE1; MYB; JUP; BTG1; NR2F6; ESR1; MEIS2
Down-regulation 31 FOSL1; MYC; FHL2; EGR1; MAFF; EGR3; KLF10; TSC22D2; EGR4; HNRNPD; SOX9; REPIN1; EGR2; HES1; FOSL2; ADRB2; IRX5; IFI16; BHLHE40; XBP1; PTRF; ID1; HOXA10; SATB2; NKX3-1; FOXC1; NRIP1; SNAI2; NR4A2; HOXC6; KDM5D