Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17767 Geldanamycin GSE70138 MCF10A Human 24h 1.11uM EID0021
Types Number Response transcription factors
Up-regulation 593 CALCOCO1; FOXO4; ZNF91; HBP1; EZH1; ZSCAN16; CBFA2T2; PBXIP1; PNRC1; PHF1; ERBB4; TCF15; ZFHX3; ZKSCAN4; IRF9; RXRB; SUPT7L; ZNF224; SMARCC2; CRYM; TULP3; ZKSCAN3; CIR1; KLF13; PITX3; ZNF362; ZBTB44; TBX6; ZNF350; ZNF85; NR3C1; GBX2; MYOG; GLI1; MZF1; ZKSCAN1; ZNF112; GRHL2; CBX4; ZNF76; ZSCAN9; ZNF132; MYF5; FOXA2; SIX6; MED12; SPI1; BTG1; BARX1; HOXB3; NFATC3; ZBTB7A; PKNOX2; BRD4; ZSCAN18; BAZ2A; PRDM2; PLAG1; MEOX1; NEUROG3; KMT2A; DYRK1B; EPAS1; TBX21; TEAD3; ZNF93; SMARCD1; EMX1; HOXB5; FOXL1; TBX10; CUX1; MEIS2; APBB1; SOX2; SRY; ZNF257; CSDC2; PHIP; CDX2; ATOH1; ZNF223; CRX; ETV3; NR5A1; ZNF133; SALL2; ZNF419; KDM5C; PBX1; TBX5; HIF3A; TCEA2; ZNF225; WNT4; HOXA6; SIRT2; ZNF175; ZNF117; KLF3; ZNF606; TRPS1; SIX5; NCOA1; ZNF345; SIM1; HOXC13; ZNF500; BCL11A; HIPK1; POU2F3; TP73; HMX1; RFX3; IRF6; GLI2; TBX4; ARNT; ZNF467; NR6A1; ZNF668; ONECUT1; ALX3; HOXA3; TLE2; POU3F4; LHX3; TSC22D3; TSC22D4; HOXB1; SOX3; ZNF669; TLX3; TULP1; ZNF234; PDX1; SRCAP; POU2F1; HES2; FOXO1; ZIC4; EHMT2; ZNF506; FOXN3; ELF4; EYA3; TRIP11; PRDM9; ZXDB; MEF2D; NFATC4; TCF21; VENTX; FOXF2; ZNF623; GATA3; RFXANK; GRIP1; CIITA; ZNF667; ZNF222; ZNF155; HNF1B; NFKB2; OSR2; TLX1; ID4; HNF4G; TRIM33; MYOD1; ETV2; ZNF415; HMBOX1; CREBL2; RFX2; RAX; DLX5; PAX6; FOXN1; SIN3B; ZNF165; DBP; MKL2; FOXH1; NHLH1; FOXA1; CCNH; ZSCAN2; HDAC7; LMX1B; ZNF814; PPARA; CHD2; ZNF557; FOXJ1; TDP2; ING4; ZNF174; MECP2; ZBTB3; THRA; ZNF214; HOXD1; ZNF682; ZNF135; RING1; ZNF688; ETV7; IKZF4; ZNF157; ZNF154; HOXD13; GSC2; ZNF81; MED14; ARID5A; SOX18; CBX7; NKX6-1; VHL; ZNF14; LZTR1; HOXD3; DMRT1; DCC; USP21; ARID5B; ZNF778; SOX13; ZNF574; TCF4; BAZ2B; L3MBTL1; POU6F2; ZNF749; RBPJL; FEZF2; HOXB8; ZBTB7C; DLX4; ZNF136; HEY1; MDM2; CREB3; HIC1; NOCT; ZNF33B; FOXE3; TCF12; ASCL3; FOXB1; KAT2B; IKZF3; PRDM14; MAML3; SCRT1; PEG3; ZSCAN32; NR1I3; EVX1; MECOM; RSF1; GATA6; TP63; ZNF79; ZNF287; TFAP4; ZNF394; ZNF430; POU4F3; ZNF423; RORC; LDB1; HNF4A; THRB; PAX7; PAX2; ALX4; NPAS1; HINFP; SP140L; ZFHX2; HLX; ZNF80; HOXD12; GCM1; ZNF671; TSHZ2; ZNF331; ZNF471; TEF; GCM2; LMO1; POU1F1; ZNF573; SOX14; ZSCAN31; MLXIPL; ZNF613; ZNF235; ZEB1; NR4A1; SCAI; HOXB13; TAF1C; ZIM2; HIVEP2; MSX2; ZNF780B; ZNF589; TFEB; TAL1; MDM4; ZNF444; STAT2; AES; FOXD3; NCOA2; ZNF43; CARF; ZIC1; FOXI1; DLX6; NAB2; SUPT3H; CDX4; SOX21; ZNF74; ZNF711; HIC2; ZNF254; ZNF12; TAF6L; MAPK8IP1; TONSL; ACTL6B; SKIL; ZNF304; HDAC5; GBX1; FOXJ2; RARB; ERBB2; ZKSCAN8; NR0B2; ZNF337; PROP1; ARID3B; RFX1; E2F8; ZNF549; NEUROD6; POU3F3; ZNF253; TCF7; OVOL2; ZNF550; TERF1; CEBPD; MED25; NHLH2; FOXF1; TULP2; MEIS1; MBD1; POU6F1; AFF2; RBFOX2; BNC2; ZNF177; CDIP1; ZNF674; ZNF75D; ZNF771; SUMO1; ZNF586; ZNF264; ZNF205; VAX2; SOX17; SOX5; SNAPC4; LHX1; ZNF407; ZBTB48; DDIT3; NEUROG2; MYCL; ZNF446; TBX1; TDRD3; PAX4; TBX3; SHOX; LBX1; ASCL2; CEBPA; BPTF; NR5A2; AR; HOXA4; HIVEP1; ZNF695; SKI; NEUROD2; ZBTB7B; ZNF580; POLR3C; ZNF611; HDAC9; JUP; NR1H2; TFDP2; BRDT; POU4F2; NPAS2; TCF3; SSX7; SP2; SETDB1; MAK; CBX2; CREB5; WHSC1L1; E4F1; ZFPM2; TRIM22; ZNF440; SSBP3; PAX1; TGIF2; NR2C1; CDC5L; ZNF34; ZNF354A; CUX2; PIAS4; ZNF141; BRD2; CEBPE; VGLL1; PBX2; KAT8; AFF3; MYRF; CAMTA2; SOX1; MLLT1; KAT6A; SHOX2; LITAF; ZNF180; PRDM12; CIC; ZNF268; AEBP1; SMARCA1; ZNF536; CHD9; ZXDC; TCF25; BANP; ZNF768; IL16; ZNF219; PRDM10; ST18; KLF5; MEN1; CSDE1; MNAT1; TFAP2A; PBX3; CBFA2T3; ZNF512B; ZNF334; DMTF1; SOX4; KLF15; TAF6; ZNF493; ZNF44; CNOT3; PEX14; REL; ARID3A; POU3F2; CDYL; TXNIP; MBD4; RXRA; ZNF507; NEUROD1; KLF7; ZHX2; CDX1; SMAD6; GATA1; MXI1; SP4; RUNX1; MEOX2; ESR1; MYT1L; NKX3-2; ZNF701; ZNF248; THAP10; SP100; TGFB1I1; LYL1; HOXD11; TWIST1; ZBTB20; SIX3; GFI1B; ZNF195; HESX1; HOXA5; YBX2; ZNF148; TCF7L1; GLI3; KDM4C; NR4A3; ELF3; HOXB2; DACH1; COPS2; ZNF266; BRWD1; TCF7L2; TOX; STAT6; ZNF665; ZNF160; RARG; TRIB3; ZNF652; ZNF281; ZIC3; KLF11; SIX1; GATA4; CREB1; BACH2; VPS72; OLIG2; PRRX1; CREB3L2; PAX5; ELF5; NKX2-2; RYBP; CERS4; POU2AF1; LMCD1; ZNF562; NKX2-1; TFEC; NR4A2; INSR; IRF8; TLE4; BCL6; TRIM29; MAF; NFAT5; TFAP2C; FLI1; BHLHE41; LEF1; ZBTB16; GATA2; INSM1; ARNT2; SPDEF; ID3; HOXB6; LIN28A; LOXL2; SSBP2; TOB1; ID1; BASP1; WT1; ASCL1; HMG20B; SNAI2; MNDA; NR2F6; TOX3; E2F2
Down-regulation 130 FOSL1; CCNA2; MYCBP; MYC; TFDP1; EGR1; EZH2; C1QBP; PARP1; FHL2; DRAP1; RUVBL2; TBP; NUP62; DR1; RUVBL1; BAZ1A; TCERG1; RBM14; TRIM28; ZNF146; CRK; ENO1; CBFB; HMGA2; NPM1; YWHAB; GTF2A2; PTTG1; ZBTB18; RAN; PA2G4; ADRB2; HMGB1; DDX5; YBX1; PPRC1; EDF1; GTF3A; NEDD8; HNRNPD; PITX1; HSBP1; SAP30; HSF2; ZNF783; RBBP4; TBPL1; DDX54; NELFB; ENY2; SSRP1; NCOA4; RBPMS; APEX1; FOXD1; RNF141; HOXC6; HMGB2; CBX3; RHOA; ELK3; DNAJC2; RBL1; HLTF; RNF14; NFIL3; WHSC1; EGR3; TTF1; TRIM32; ZBTB24; HDAC2; SMARCA5; MTDH; RBBP8; BLM; PSMC3IP; TBL1XR1; BIRC2; KLF6; XBP1; CTNNB1; SUB1; ITGB3BP; TFAM; NFKBIA; KAT7; BCLAF1; KDM5D; HIPK3; TSC22D2; FOXM1; ASH2L; PIAS2; JARID2; PRKDC; CNBP; HDAC1; BRCA1; SF1; PUF60; RNF138; SFPQ; TAF9; CENPF; BMI1; TRIP6; SMAD5; CEBPZ; RBBP7; SUV39H1; EED; CTR9; NRIP1; GATAD2A; NFIB; MAGED1; SOX9; HOXC10; HOXB7; TSC22D1; HTATIP2; HLF; KLF2; MAFB; IRX5; FLNA; STAT3; IKBKAP