Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17670 Azd-5438 GSE70138 MCF10A Human 24h 10uM EID0021
Types Number Response transcription factors
Up-regulation 710 EGR1; ERBB4; ZSCAN18; ZNF91; TBX21; MXI1; ZNF257; ZNF606; ZKSCAN3; ZNF350; HBP1; ZNF85; TFDP2; ZNF667; HOXD3; ZNF415; ZBTB44; ZFP2; ZNF586; ZNF43; ZNF136; ZNF223; SSX3; SPI1; ZNF132; HOXC8; ZKSCAN4; KAT2B; FOXJ1; ZSCAN16; DLX2; ZNF331; CRX; ZNF682; TBX6; ZNF556; TLX1; ZNF573; ZNF93; ZNF250; ZNF117; NEUROG1; RFX3; WNT4; CALCOCO1; ARID3B; SCAI; MYNN; EMX1; ZBTB43; EHMT2; IKZF2; PRDM1; ZBTB3; ZNF426; ZNF222; ZNF506; PHF1; TCF21; ALX3; NR4A3; IKZF3; ZSCAN2; SNAI1; ZNF154; ZNF770; ZNF492; ZNF345; ZIC4; PROP1; ZNF816; SOX18; ZSCAN9; ZNF253; MED12; IRF9; POU6F2; SRY; PPARD; NR5A2; SMARCA1; FEZF2; ZNF484; NFATC3; ZNF273; NEUROG3; ASCL3; THRB; ZNF239; ZNF669; ZNF74; CREM; EP300; HAND2; HHEX; ZNF442; NR6A1; TBX5; BARX1; THRA; PRDM14; MYCL; ZNF135; SIX6; TULP3; NHLH1; SOX3; NFE2; ZNF208; WHSC1L1; CHD2; NKX6-1; HOXB8; POU2F3; LHX3; ZNF671; SALL2; RFX1; ZNF814; DCC; ZNF749; FOXH1; GATA6; CBFA2T2; PRDM9; ZNF225; NEUROD2; BCL11A; GRIP1; ZNF695; ZNF221; PDX1; ZNF571; ZSCAN31; ZNF235; MEIS2; ZNF430; ZNF589; ETV3; TBR1; GBX2; CCNH; ZNF467; SOX17; KLF13; TFAP4; HOXD12; FOXP3; HOXB1; GLI1; MECP2; HINFP; ZNF79; ZNF362; ZNF264; ZNF623; NOCT; HIF3A; BNC2; ZNF165; SOX14; NR4A2; ZKSCAN8; ZNF304; CIITA; ZIC3; SSX7; FOXE3; ZNF254; NPAS1; BRWD1; SCRT1; NEUROG2; TULP1; HNF4G; ID4; ZNF711; TULP2; GLI2; ZNF440; ZNF391; SOX2; ZNF268; ZNF780B; ZNF500; ZNF394; ETV7; POU6F1; ZNF549; ZNF81; NEUROD6; ZNF234; FOXL1; ATOH1; ZNF76; ESRRB; TAF1; ZSCAN32; ZNF507; ZNF701; ZNF550; ZNF613; NEUROD1; FOXF1; ONECUT1; ZNF214; ESR2; SIX5; TCEA2; TBX4; NEUROD4; ZNF778; LHX2; CEBPE; RING1; FOXI1; TAF1C; PBXIP1; ACTL6B; ST18; NR0B2; ZNF80; ZNF557; VHL; RBPJL; PAX4; TBX10; ING4; ZIM2; ZNF174; ZNF141; GSC2; ARL2BP; SIM1; NAB2; ZNF665; ZNF14; NRL; HOXA3; ZNF471; HES2; GCM2; NFE2L2; CUX2; MED31; ZNF140; ALX4; ZNF205; EVX1; NFKB2; THAP9; PNRC1; HESX1; ZNF134; HNF1B; MYF5; WT1; POU3F4; AFF3; SKIL; ZNF157; POU3F3; VENTX; HEYL; CDX4; BRDT; BNC1; ZNF551; ATF3; NR1H4; POU4F3; ZNF813; CDIP1; TP73; ETV6; NHLH2; ZNF195; HOXB3; ASH1L; SOHLH2; HSF4; MYEF2; DLX6; AFF2; VGLL1; PRDM2; MED25; TFDP3; ETV2; ZNF675; SSX1; HOXB5; ZNF286A; CIR1; FOXN1; PAX7; RORA; DLX5; HIC1; ZNF343; PEG3; E2F4; ZNF674; PAX2; SSBP3; ATF7; NR1I3; SNAPC4; ZNF180; SKI; ZXDB; NFATC4; CD3D; NR5A1; RAX; ZNF329; PITX3; ZBED2; TAL1; EZH1; LMX1B; ZNF580; POU1F1; GBX1; EYA3; ZNF274; ZFP69B; LIN28A; TEAD3; SHOX; MAML3; ZNF407; ONECUT2; ZNF41; CARF; ZFHX2; TUB; CREBL2; PRDM13; ZNF224; IFNB1; LMCD1; BAZ2A; DYRK1B; TBX1; ZFY; ZXDC; ZNF423; ZNF287; REL; KLF8; SOX1; ZNF493; TLX2; GFI1; MEOX1; ZNF155; ZNF529; TEF; ZNF544; OLIG2; PRDM16; ZNF10; ZEB1; ZNF184; ZFPM2; KDM5C; ZNF668; HOXD1; ZNF334; ZFP30; VAX2; RSF1; TBL1Y; TRIM24; SOX5; HLX; ZNF33B; ARID5B; DBP; RXRG; APBB1; NFE2L3; AR; RARB; UTF1; PBX1; ZNF654; GFI1B; NKX2-5; HOXD13; SRCAP; FOXO4; LHX6; NR1H2; PEX14; VSX1; ZNF124; AIRE; CBX2; PKNOX2; ZNF460; KLF11; ESRRG; NR4A1; RARG; NFIX; TONSL; NR2E1; MAPK8IP1; TLX3; FOXD3; SOX21; ZNF611; LZTR1; MAK; HDAC5; PAX3; SP4; RORB; ZNF75D; ZNF34; CBFA2T3; ARID5A; FOXL2; ESR1; CRYM; ZNF177; ZNF419; ZBTB39; L3MBTL1; NKX2-8; MSX2; PLAG1; ZNF688; GCM1; KDM4C; CRTC1; RELB; ZBTB7C; MLLT1; IRF6; ZNF112; FOXB1; HNF4A; ZNF44; EPAS1; IRF5; GATA1; CAMTA2; DLX4; E4F1; RCOR3; TWIST1; ZBTB7B; MYCN; TRPS1; ZNF107; DMRT1; PPARA; ZNF562; LBX1; ZNF232; HOXD9; CEBPD; HOXC5; TCF4; GRHL2; HOXA6; ZNF768; THAP7; LMO1; KLF15; ZMIZ1; MYBL1; CBL; CDK2; PROX1; NACA2; ZNF536; RFX2; RFXAP; ARID3A; ASCL2; TGFB1; CAMTA1; TSHZ2; PHOX2A; DOT1L; STAT2; MYRF; POU2F2; HIC2; HIPK1; ZFP37; TDP2; PBX3; RBL2; PHIP; MBD4; HDAC9; MAP3K10; TBX2; PBX2; BACH2; KLF1; TAF4B; CBX4; MEOX2; MZF1; IKZF4; HMX1; EN2; MYT1; POU4F2; SHOX2; TAF6L; OVOL2; MEIS1; TBX19; MDM2; CSDC2; ZNF510; SIX3; TTF2; ELK4; CERS4; FOXF2; DACH1; NFAT5; TGIF2; POU3F2; ZBTB48; ZNF215; TFAP2B; RORC; SIN3B; STAT4; SALL1; HMBOX1; CREB3L2; ETS1; AEBP1; FOXN3; TCF15; FHL5; LHX1; ZNF354A; MDM4; ZNF248; ZNF219; HAND1; PAX1; NANOG; TERF1; ARID1A; KLF3; BACH1; SMAD6; KLF7; BRD4; HEY2; OVOL1; ZNF22; JAK2; PRDM5; PRDM12; SP140; CDX1; PRDM10; TCF3; HIPK2; ZKSCAN1; ZNF133; SUMO1; TFEC; HOXC4; ZNF835; TCF7L1; NKX3-2; TGIF1; ZIC1; FOXE1; FOXJ2; TOX3; ZFHX3; TFAP2A; EBF2; MNDA; SUPT3H; MED14; PRRX1; OSR2; ZNF148; POU5F1B; BCL3; ZNF444; BARX2; KMT2D; FOXC2; ZNF175; ZBTB20; ARRB1; PIAS4; MEF2D; NCOA2; HEY1; MAFK; HIVEP1; ZNF771; THAP10; HIRA; NR2F1; HNF1A; ZNF358; CIC; ZNF292; SP100; TAF11; NFIC; E2F8; ZBTB17; SP140L; MXD3; FUBP1; TCF7; TXNIP; VPS72; SMARCC2; INSM1; TLE2; FOXA2; CBX7; CCNT1; YBX2; PAX6; ASCL1; NR3C2; HOXB2; HOXD11; TBX3; LITAF; MKL2; IRF7; ELF4; ZNF211; RERE; PAX8; MITF; NR0B1; PGR; MYT1L; GATA2; IKZF1; EMX2; TULP4; ATN1; PTRF; ARNT2; ZNF12; IRF8; THAP11; E2F5; JUNB; PCGF3; GATA4; LEF1; EGR2; HOXB13; CHD9; EN1; TGFB1I1; ZKSCAN7; MECOM; ZNF32; FOSL2; INSR; FOSB; TRIB3; FLI1; HOXB6; MEF2C; MAF; TCF7L2; SSBP2; BHLHE41; FOS; TRIM22; ZNF652; SPDEF; ZNF83; PAWR; ID3; MTF2; CNOT3; JUN; JUP; ZBTB16; NKX2-2; SOX11; KLF9; IRF4; POU2AF1; ZHX2; WWTR1; CREB1; DAXX; CITED2; PPARG; E2F2
Down-regulation 182 USP22; CCNA2; MYC; FOSL1; NUP62; RBM14; ARID4B; TCERG1; EZH2; FOXJ3; HOXA5; TBP; TRIM28; MED6; UBE2I; PARP1; YWHAB; CREG1; RBBP4; SNW1; XRCC6; CRK; NONO; BAZ1A; RAN; NPM1; HDAC1; RUVBL2; DNAJC2; SMARCE1; AATF; PTTG1; NACA; CDK7; GTF2A2; NRIP1; HNRNPD; CTR9; ZNF146; ATF6; ADRB2; TFDP1; HSF2; ENO1; HDAC2; REXO4; FHL2; ZBTB18; NCOA4; YBX1; NELFB; PA2G4; BMI1; FOXO3; BAZ1B; CENPF; PDLIM1; KDM2A; DDX5; BCLAF1; CBX3; RNF4; HOXC6; DR1; NCOR2; UBP1; EDF1; SSRP1; SMARCC1; ATF1; SFPQ; CEBPB; DRAP1; MLX; TBPL1; MEF2A; MTDH; BRPF1; KAT5; PITX1; HMGB1; NCOA6; RBBP7; ENY2; TBL1XR1; BTF3; HSBP1; ITGB3BP; BRD8; ADNP; HOXB7; DDX54; TRIM16; NFE2L1; PMF1; MED24; ETS2; CBFB; ORC2; TP53; APEX1; HOXA10; ZNF672; BASP1; NEDD8; SAP30; ATF4; PATZ1; TRIP6; MTA1; NKX3-1; CENPB; MBD2; PUF60; PHF2; FOXD1; ING2; HMGB2; RNF6; CNOT1; BRD3; C1QBP; JARID2; PPRC1; XBP1; RCOR1; MAX; CTBP2; DEK; MED1; TAF10; HIPK3; SMARCA5; PIAS3; ASH2L; HMGB3; TRIM32; PURA; SUV39H1; SREBF1; KAT7; NRBF2; NR2F2; GTF2IRD1; PRKDC; TSC22D1; SF1; CTNNB1; VGLL4; CRY1; SCAND1; HDGF; RBM39; PQBP1; PBRM1; GATAD2A; BLM; ELK3; VEZF1; IRX5; NAB1; CEBPZ; IKBKAP; DDX17; TRIM29; SIX2; SOX9; FOXM1; SMARCA2; ELF1; ZBTB38; TBL1X; NFKBIA; HLTF; TSC22D2; FLNA; PIR; HMGN3; KLF5; ZFP36L1; TOB1; TLE1