Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17642 Afatinib GSE70138 MCF10A Human 24h 1.11uM EID0021
Types Number Response transcription factors
Up-regulation 193 TSC22D3; FOXO4; CREG1; TRIM29; ZNF160; TRIM22; SOX4; PBXIP1; ELF3; HBP1; ZKSCAN1; ID2; AES; TCEB2; FOXO3; HDAC5; CALCOCO1; MXI1; TP63; SREBF2; ZNF131; SRCAP; IRF9; ZNF44; ZMIZ1; WNT4; BTG1; ZNF33B; EZH1; KDM4A; ZNF91; ZNF768; HEY1; ZNF611; PNRC1; TRIM16; ZNF652; PHF20; GATA3; ZSCAN31; NCOA3; ZBTB16; ZNF688; CREBL2; ARHGAP35; SOX2; JUP; ZNF430; CERS6; ATF3; DYRK1B; EPAS1; NR3C2; ZNF14; MZF1; IRF6; CUX1; TRPS1; MEOX1; ZNF224; TLE2; ZNF665; TCF25; CBX7; ZNF544; ZFHX3; ZBTB43; ZNF264; ELF4; BCL11A; TEAD3; NCOA2; ZNF117; ZNF217; RBL2; ID1; ZNF358; TERF1; ZNF93; DLX4; SALL2; PRDM2; OVOL2; INSM1; ZMYM2; TP53; MKL1; FOXN3; ATF7IP; ZNF623; ZNF529; ING4; IRF8; ZNF43; BCL3; MEIS1; SREBF1; PPP1R13L; CEBPD; REPIN1; SP110; MXD4; ZNF536; NR5A1; SIX2; HMBOX1; ZNF136; CDIP1; NFKBIA; CSDC2; ZNF195; AFF2; SNAI2; NHLH2; SSBP2; HOXB1; MYCL; HDAC9; GRHL2; TCF7; FOSL2; TCF4; IRF7; ARID5B; ERBB2; MYCN; STAT4; TOX3; ZNF721; MAF; E2F5; LITAF; SATB1; TOB1; PPARGC1A; TWIST1; SSBP3; SPIB; CEBPA; REL; HOXB13; CUX2; KAT2B; SOX3; PDLIM1; RXRA; BCL6; ZSCAN18; SOX13; BACH2; ARID1A; ZNF12; CD3D; MNDA; VGLL4; SMAD7; FOXG1; HOXD1; ZNF512B; FOXA1; PBX1; BHLHE41; ZHX2; FOXO1; ASCL1; CBFA2T3; MYRF; AHR; OSR2; TLE1; HMGN3; RORA; EYA2; ID3; SCAND1; GATA6; ST18; TXNIP; CERS4; INSR; ZBTB20; ZNF423; TFAP2C; ZNF331; NKX2-1; ID4; ARNT2; KDM5B; MEIS2; AFF1; HOXB2; DACH1; POU2AF1
Down-regulation 92 FOSL1; CCNA2; EZH2; EGR1; CHAF1B; HMGA2; PSMC3IP; WDHD1; BRCA1; TFDP1; DR1; DRAP1; BCLAF1; CENPF; PTTG1; CDK2; FOXM1; EGR4; RBL1; HMGB2; DNMT1; NUP62; WHSC1; TRIM28; FHL2; YEATS4; WDR77; MYCBP; ITGB3BP; C1QBP; HMGA1; TAF1A; EGR3; CCDC59; ZNF473; HDAC2; BATF3; PA2G4; GMNN; TFAM; CARM1; SUB1; GCFC2; HNRNPD; YWHAB; RBM14; RBBP8; ETV4; BLM; ASH2L; ETS1; CBX3; RUVBL2; DEK; AGO2; SAP30; BRIP1; EED; SMARCA5; SFMBT1; ZNF281; CCNE1; CBFB; MYBL2; ILF2; PMS1; BMI1; MSX1; ZFP36L1; NPM1; TGFB1I1; XBP1; SUV39H1; BHLHE40; RNF138; TAF9B; TEAD4; WWTR1; NKX3-1; ING3; EGR2; ZBTB38; ELK3; NFIB; NR2F2; RBPMS; HLTF; LEF1; MNAT1; LOXL2; WT1; HOXC6