Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17640 Afatinib GSE70138 MCF10A Human 24h 10uM EID0021
Types Number Response transcription factors
Up-regulation 508 TSC22D3; HBP1; MXI1; ERBB4; CALCOCO1; CIR1; IRF9; PNRC1; ZKSCAN4; PBXIP1; TFDP2; SUPT7L; ZNF253; ZNF91; ZNF611; ZNF665; KAT2B; ZNF117; ZNF44; ARNT; ZNF160; ZNF350; TLX1; HDAC6; HINFP; ZNF14; ZNF711; TBX6; BHLHE41; NFATC3; ZNF33B; SALL2; ZNF85; EZH1; CBFA2T2; ZNF273; DLX4; ZSCAN31; MEIS2; ZSCAN16; ING4; ZBTB44; HDAC5; ZNF688; ZBTB3; ATF2; ZNF415; ZNF165; BCL11A; GBX2; ZSCAN18; ZNF257; MED12; FOXO4; ZNF74; ZNF667; ZNF225; ZNF816; ZNF174; ZNF669; ZNF43; TP63; POU2F3; TBX19; TCF7; ZKSCAN1; CARF; ZNF426; SOX3; HES2; ZNF136; DBP; RING1; HDAC9; ZNF224; NEUROG1; ZNF778; ZIC4; TBX5; ZNF93; ID4; ZFHX3; ZNF132; THRA; ZNF492; SCAI; ZNF484; ZNF175; MYRF; HOXC8; ZFX; ZNF177; L3MBTL1; THAP3; ZNF222; BARX1; MNDA; ZNF675; TWIST1; CREBL2; ZNF506; DMRT1; GRHL2; TDRD3; NR2C2; PHIP; ZKSCAN3; JUP; CBX7; ZNF552; ZNF768; EPAS1; ST18; ZNF141; SOX10; ZNF362; SUPT3H; ONECUT2; ZNF430; ZNF682; ZSCAN9; ESR2; ZNF254; TLX3; ZNF154; TEAD3; ZNF652; ZNF606; ZNF304; TFEC; TULP3; RARB; RFX3; ZNF155; ETV6; TRIM29; CDX2; PRDM13; GLI2; ZNF623; ZNF292; HOXB3; ZNF589; ZNF81; NAB2; NR5A1; NEUROG3; ZKSCAN8; NFE2; EHMT2; SIX3; TFAP2C; KLF3; ZNF79; ATN1; HEY1; ZNF214; HTATIP2; ZNF268; TFEB; ZFP2; TBX10; GATA6; ZNF467; ZSCAN32; MECP2; CIZ1; TRPS1; ZNF780B; ZNF208; TBX4; VHL; ZNF549; POU1F1; HIC2; PBX1; WNT4; MEOX1; TBX1; ZFHX2; ZNF205; PAX6; POU3F4; SOX2; ZNF84; CRX; ZNF510; MZF1; PRDM10; ZNF157; ZNF223; CBX4; GRIP1; ZNF394; ELF3; CIITA; NR6A1; ZNF221; ZIC3; NEUROG2; MYCL; KLF13; ETV2; DYRK1B; MYEF2; REL; ZNF468; ZIC1; THAP7; SIX6; ZNF107; RSF1; ARID3B; ALX3; FOXF1; HOXA2; ZNF80; SRY; TFE3; SOX14; ZNF613; SIX5; ATF3; ZNF571; ZNF701; IKZF3; ZNF442; UTF1; KDM5C; SOX5; ID2; PROP1; HSF4; ZNF749; EHF; HNF4G; PKNOX1; ZNF133; ZNF671; TERF2; TAF1C; ZNF334; SSX1; PPARA; ZNF75D; ZNF112; CSDC2; ZNF674; ZNF695; ZNF184; DDIT3; ZXDB; FOXN3; RXRG; RBPJL; ZNF264; EMX1; SOX13; MEIS1; PRDM2; ZNF195; ZNF557; ZNF500; GBX1; ONECUT1; NR5A2; MYF5; AFF3; HOXA6; ZNF135; RARG; ZBTB14; HOXD12; GCM2; PRDM9; HOXD3; VENTX; SNAI1; HNF4A; RORC; FOXJ1; WT1; TAF1; POU6F2; SOX18; NFIX; SCRT1; ASCL3; FOXE3; ARID5B; TFAP2A; NCOA2; ZMYND8; PIAS4; SSBP3; MYCN; SP2; THRB; SOX17; ZNF471; RAX; GSC2; ZNF440; TOX4; POU6F1; TCEA2; ZHX2; FOSL2; NFATC4; MBD4; ZXDC; TP73; RFX1; FOXI1; HOXA4; POU4F3; APBB1; TCF21; SETDB1; THAP9; HESX1; ZNF329; ZNF407; IRX4; ZNF586; PKNOX2; OSR2; TEF; NCOA3; SHOX; BRWD1; CUX2; MED14; ZNF140; FEZF2; MNT; GCM1; TSHZ2; TCF7L2; BARX2; FOXD3; FOXA2; ZNF345; SMARCC2; TOX; PAX4; EVX1; ZNF532; ALX4; NKX2-5; SMAD6; ZNF536; NR1H2; CBX2; DCC; SPI1; RUNX1; CDX4; ZNF358; HLX; PRDM14; ZNF331; NHLH1; DLX5; SIN3B; LIN28A; RARA; ZNF354A; CRYM; TAF6L; POU3F3; BNC1; CHD2; CAMTA2; FOXH1; ARID3A; HOXB1; KLF11; CDIP1; TTF2; IRF6; STAT2; BRDT; HIF3A; SP140L; AFF2; ZNF124; SP140; ZNF423; ZNF217; BNC2; NHLH2; WWC1; SHOX2; MAML3; BHLHE40; ZNF219; BCL6; ASCL2; VPS72; NCOA1; SRCAP; HOXD1; TERF1; OVOL2; SIM1; SUPT4H1; DACH1; MAPK8IP1; CEBPD; NFKB2; ZNF721; ZNF573; LHX3; LYL1; ZNF562; ZNF835; ZNF10; MAK; NFE2L3; MDM4; CREM; ELF4; ELF5; MLLT1; NR4A3; SP4; CBFA2T3; NKX3-2; BACH1; BTG1; CERS4; PLAG1; INSM1; HMBOX1; AR; INSR; SOX21; TLE2; GFI1B; ZNF32; NR3C2; ZNF432; NR1H4; MYBL1; FOXF2; NR0B1; PEX14; EYA1; HOXB13; CHD9; VDR; SSBP2; LMCD1; TSG101; PRDM12; HIPK2; MECOM; HOXB5; HAND1; PIR; NR4A1; AEBP1; TRIM16; NPAS2; SOHLH2; SMARCD3; NANOG; GATA4; ZBTB20; SPDEF; TRIB3; VGLL1; RXRA; TBX3; JUND; LEF1; NR4A2; FOXC1; TSC22D1; IL16; FLI1; TOB1; AES; PBX3; PRRX1; CITED2; ZNF83; RORA; CREB1; MEF2C; HEY2; TXNIP; ARNT2; LOXL2; HOXB6; ESR1; TCF4; MAF; EMX2; TRIM22; SOX9; ASCL1; ZFPM2; TLE1; HOXB2; IKZF1; SATB1
Down-regulation 126 FOSL1; MYC; MYCBP; CCNA2; FHL2; DRAP1; BAZ1A; EZH2; TFDP1; TRIM28; EGR1; HMGA2; RUVBL2; PARP1; RUVBL1; PA2G4; RBM14; GTF2A2; TCERG1; BCLAF1; C1QBP; HMGB1; NPM1; YBX1; NUP62; NACA; YWHAB; PTTG1; CBFB; TBP; SUB1; HNRNPD; PPRC1; BRCA1; NR2F2; DNAJC2; DR1; EDF1; ELK3; USP22; RHOA; HDAC2; WHSC1; HMGA1; CTR9; MBD2; RNF4; NFKB1; NOC2L; RAN; ZNF146; SMARCA5; TFAM; SFPQ; NFIB; BASP1; CENPF; WDR77; ENY2; ATF1; ASXL1; ADRB2; ENO1; ITGB3BP; MTDH; SMARCC1; TAF1D; MSX1; SMARCE1; BRD2; SMAD7; SNW1; RNF138; XBP1; GTF3A; CEBPZ; TRIM32; HOXC6; DEK; ZBED4; UBP1; CNBP; SUV39H1; ORC2; RNF6; RBBP4; CCDC59; PSMC3IP; NRIP1; PRKDC; SMAD2; EED; TAF9; PIAS2; NEDD8; ETS2; FOXM1; RBPMS; HMGB2; ZFP36L1; HSBP1; ELF1; BIRC2; BLM; JARID2; GATAD2A; DDX5; ZNF281; HLTF; PURA; FLNA; PTRF; TSC22D2; PBRM1; ZBTB38; BMI1; ZMYM2; ZNF22; IKBKAP; MED1; STAT5B; PUF60; WWTR1; MNAT1; MAFB; MYBL2