Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17542 Alvocidib GSE70138 MCF10A Human 24h 1.11uM EID0021
Types Number Response transcription factors
Up-regulation 815 ERBB4; ZNF556; EGR1; ZKSCAN4; TFDP2; ZBTB44; FOXJ1; HOXD3; HBP1; EPAS1; ZKSCAN3; HOXC8; ZNF350; THRA; NAB2; ZNF253; ZNF816; TULP3; MYNN; NEUROG1; SSX3; ZNF778; TAF1; ZNF415; ZSCAN16; ZSCAN9; ZNF175; NKX6-1; ZNF696; SUPT7L; SOX17; ZNF250; TBX21; ZNF91; PEG3; MXI1; HAND2; TBX6; CRX; ZNF93; SMARCA1; SIX5; ZNF606; ZNF467; ZKSCAN8; EMX1; SKIL; CREM; WT1; LHX2; THAP3; ZNF222; ZNF484; SALL2; NHLH1; SOX18; ZNF257; ZFP2; TULP1; NEUROD2; KAT2B; ALX3; SNAI1; ZNF286A; ZFHX2; SPI1; IKZF2; ZNF223; TLX1; NRL; ZNF132; NPAS1; ZNF589; ZNF667; ZNF225; SCAI; ZSCAN18; ZNF135; HINFP; GATA1; NR6A1; RBPJL; PROP1; ZNF136; IRF9; REL; ONECUT2; TUB; CREBL2; NFATC3; POU2F2; ZSCAN32; NR1I3; MECP2; SOX2; TULP2; GRIP1; BRWD1; HOXB8; ZNF154; ZNF343; LHX5; PRDM14; RFX1; IKZF3; ZNF14; ZNF682; ATF7; CARF; GLI2; ZNF695; ASCL3; MYCN; ZSCAN2; ZBTB3; RFX3; ZNF688; ZNF423; ZNF85; ONECUT1; ATOH1; SSX7; IFNB1; LMX1B; ZNF224; ZNF362; ZNF557; SUPT3H; SOX21; CAMTA1; TP73; LZTS1; TLX3; ZNF444; ZNF221; LHX3; ZNF500; TFDP3; MYCL; PHF1; AFF4; NR2C2; SRY; HNF4G; NEUROG3; HIC1; PRDM2; WHSC1L1; ZNF492; ID4; EVX1; ZNF74; POU6F2; ZNF174; PHOX2A; ZNF669; FOXL1; FOXA2; BNC2; NFKB2; POLR3C; TGIF2; ZNF665; ZNF550; ASH1L; FOXP3; NOCT; PPARA; ING4; ZNF442; MED12; DLX6; ZNF345; ZNF142; ZNF235; EYA3; ZNF771; ZNF814; HIF3A; KLF13; PDX1; MYF5; ALX4; NEUROD6; TBX5; DLX2; MYOD1; ZNF749; FEZF2; PRDM9; OLIG2; CBFA2T2; ZNF701; ZNF287; TAF1C; LYL1; PKNOX2; ZNF668; HIPK2; ZNF329; MAML3; SCRT1; ZNF124; ZNF671; CCNH; ZIC4; FOXE3; ZNF205; NR5A2; TFAP4; PROX1; ZNF536; PAX7; ZNF623; PITX3; ZNF43; ZNF580; POU3F4; HSF4; LZTR1; FOXH1; NFATC4; ZNF430; NKX2-8; NEUROD4; PAX2; SIX6; ESR2; NKX3-2; ST18; CHD2; ZNF654; ETV3; SOX14; VENTX; GBX2; RXRB; TRPS1; TBX19; ZNF273; SHOX; ZNF506; ARID3B; ZNF549; PAX3; CBL; ZNF426; ETV2; ELK4; TCF21; TBX4; RFXAP; CIR1; ZNF264; ZNF79; HMBOX1; ZNF239; ZNF571; BARX1; ZBTB43; SOX5; L3MBTL1; NR0B2; ZNF34; PRDM13; ZNF780B; PHOX2B; VSX1; NR5A1; DBP; PRDM16; HEYL; RSF1; ZNF711; HOXD12; CBX8; MEIS2; HESX1; CUX2; VAX2; ZNF324B; ZFP37; ZNF274; POU6F1; ZNF510; ETS1; ZNF141; HNF4A; ZNF197; HDAC6; ZNF507; ZNF639; CDIP1; ZIM2; BARX2; CDX4; VGLL1; RAX; TLX2; ZNF177; ZKSCAN5; THRB; ZNF391; ZNF117; CEBPE; ZNF140; HOXD1; ZNF10; SP4; ZIC1; SKI; ZNF248; MEIS1; NR4A3; GFI1B; GBX1; ZNF528; ZNF214; TONSL; POU4F2; ZNF646; CBX4; ETV6; POU4F3; ZNF80; NEUROG2; NEUROD1; ZNF614; ZNF75D; KLF7; CD3D; MLLT1; HOXA6; POU3F3; ZNF573; POU2F3; TBX10; ZXDB; ESR1; FUBP1; GSC2; ZNF770; RFX2; ACTL6B; ZFHX3; MAK; GFI1; HNF1B; ATF2; EHMT2; CHD3; ZNF419; ZNF586; THAP9; TEF; PKNOX1; ZNF134; FOXB1; ZNF835; AFF3; PAX4; NFE2L2; ZNF234; TBL1Y; CALCOCO1; SSX1; ZNF471; BACH2; ZNF157; LMO1; ZEB1; SOX3; ZNF180; ZNF493; ZNF131; MYEF2; RNF2; ZNF304; ZNF613; DCC; ARNT; PRDM5; ZBED2; TBR1; ZNF334; HOXC5; ESRRB; ZFP30; AIRE; ZNF331; MEOX1; TSHZ2; ZNF208; ZBTB7B; TRIM33; ZNF81; FOXN1; HOXB1; HOXA3; HES2; MDM4; ZFY; FEV; VHL; CAMTA2; ZNF394; GATA6; NKX2-5; ZIC3; FOXI1; TFAP2B; ZFPM2; ZNF552; MED25; KLF3; ZHX2; ZNF41; LHX1; CBX2; AFF2; ZNF674; TCEA2; NFIX; MAPK8IP1; GCM2; CDX1; SALL1; TSC22D4; KDM5C; POU1F1; FHL5; ZBTB39; OVOL2; BCL11A; MYOG; STAT2; MZF1; MSC; IKZF4; ZKSCAN7; GCM1; LBX1; HLX; CCNT1; TBX1; YEATS4; GLI1; RUNX2; BRDT; ZNF268; FOXD3; YEATS2; PEX14; SIX3; ZBTB20; RBL2; SNAPC4; BNC1; SOX1; POU3F2; LHX6; ZNF611; PRDM8; NR1H4; HDAC9; ZNF407; ZNF254; ZNF155; ZNF16; ZNF133; NR1H2; PPARD; PAX1; FOXF1; KLF15; ZBTB7C; MED31; HAND1; SPIB; ZNF480; ARID5A; SHOX2; PML; SMAD9; ZNF440; CIITA; CSDC2; DOT1L; EBF2; TFEB; ATF6B; RARB; FOXC2; HLF; HOXA2; ZNF629; HMX1; SUV39H2; DYRK1B; ARHGAP35; NFAT5; ZNF768; HIC2; MXD4; MDM2; GATA2; TRAF6; SMARCC2; HNF1A; HOXB5; ZNF211; MYT1; ZNF195; SMAD6; FOXN2; ZNF33B; RING1; DLX5; KLF9; POU2F1; NFE2; E4F1; EP300; CEBPZ; ESRRG; HIF1A; ZNF652; ZNF529; LMCD1; RORB; MSX2; ARID5B; HOXB3; TAF4B; PRDM10; ZNF675; HDAC5; TAF5; EZH1; HOXC4; ZNF354A; PAX6; ZBTB6; GTF2A1; CDX2; NACA2; ASCL2; ZFP69B; SRCAP; FOXE1; POU3F1; YY1; ZNF44; PAX5; MYT1L; EMX2; RXRG; MAP3K10; EHMT1; ETV7; HABP4; SOHLH2; MYRF; ZBTB32; ZSCAN31; NCOA1; THAP7; TFAP2A; WNT4; EN2; BAZ2A; NR2F1; SUPT5H; ARID3A; TAF6L; BAZ2B; RORC; VPS72; SOX11; NR2E1; HHEX; ZNF148; PAX8; GMEB2; ZNF358; ZNF8; IRF5; THAP10; KLF8; ZXDC; CRYM; ZNF232; CREB5; BHLHE41; MLXIPL; ZNF460; ZHX3; HDAC11; RARG; TOX4; PGR; CRTC1; PNRC1; STAT4; MBD4; ZNF200; PRDM1; BRIP1; DACH1; FOXJ2; HMGXB3; HEY2; ARRB1; YBX2; TRIM24; SP140; FOXO4; CBFA2T3; MAFK; DMRT1; KMT2D; HOXA4; HOXD13; RYBP; NKRF; BTG1; E2F8; TAF5L; MXD1; TAL1; CERS4; AR; MXD3; MED14; HIVEP1; PIAS1; TMF1; ZNF226; ZNF551; DLX4; UTF1; SSBP3; ZNF112; BRF2; MNDA; ZBTB17; E2F4; NR1I2; OVOL1; CREB1; TCF7L1; HOXC11; TCF7; CEBPD; TOX; SPDEF; NFX1; TWIST1; FOXL2; SMARCD1; SIRT7; MEF2D; BPTF; TCF15; MNX1; SETDB1; APBB1; ZNF710; NCOA3; SSBP2; GRHL2; TRIM25; NHLH2; MYBL1; LIN28A; SAP130; ZNF184; ZNF202; PRDM12; ARL2BP; BRCA2; NR4A2; ZNF787; RORA; PBX1; ZBTB48; TULP4; ZNF215; TAF7L; RBFOX2; ASCL1; CUX1; NKX2-2; KDM5A; PHIP; RFXANK; ELF4; NANOG; SOX10; ZBTB16; CREB3L2; DMTF1; ZNF443; IRF4; ANKRD1; ERF; MKL1; ZMIZ1; ELF5; ZNF107; JUN; CCNE1; SIN3B; ZNF160; AEBP1; SOX12; SP2; PIAS4; ZNF12; TAF6; SP100; KDM4C; BANP; PCGF3; TCF7L2; E2F5; GATA4; ARNT2; TCF4; ZNF189; HOXD11; RARA; ZNF292; PAXBP1; NR3C2; WWC1; HOXB2; TTF2; ZNF562; IRF6; NR4A1; IRF7; TEAD3; EHF; ID2; SERTAD2; TLE2; POU5F1B; ZNF532; ZNF219; CEBPA; NLK; TCF3; ZNF516; TFEC; CNOT2; EGR2; TDP2; SOX13; ZNF165; ING3; BACH1; PBX2; RERE; KLF11; TBX2; ZKSCAN1; ZFHX4; PTRF; FOS; TBX3; STAT1; ZNF281; BCL6; TRIM22; ZNF512B; IRF8; NFE2L3; MEF2C; HIRA; BBX; CHD7; ZNF721; ATN1; FLI1; AHR; FOXG1; CBX7; EN1; FOXC1; NKX2-1; HOXB6; NR1D2; NCOA2; POU2AF1; MECOM; JUP; LEF1; IL16; TRIB3; MYB; PAWR; MEOX2; EYA1; HEY1; OSR2; DAXX; E2F2; MAFB; IKZF1; INSR; TXNIP; NR2F6; MNAT1; INSM1
Down-regulation 196 USP22; FOSL1; YBX3; MYC; CCNA2; TCERG1; HDAC1; NUP62; TRIM28; GTF2A2; YBX1; UBE2I; FOXJ3; RBM14; CREG1; FHL2; RAN; EZH2; YWHAB; ATF4; TBP; RBBP4; C1QBP; ADRB2; DRAP1; NPM1; NACA; BMI1; BAZ1A; NONO; CBFB; BTF3; MYCBP; BCLAF1; RUVBL2; PCBD1; PTTG1; NCOA4; TRIP6; MED6; SFPQ; TAF10; PDLIM1; ENO1; CEBPB; SNW1; SMARCE1; GTF3A; XRCC6; MED24; HNRNPD; CNOT1; CDK7; PRKDC; ZNF146; HOXB7; HMGB3; HOXA5; RNF6; PMF1; ILF2; CTBP2; CENPF; TFDP1; UBP1; APEX1; PA2G4; ARID4B; NEDD8; ATF1; FLNA; ZBED4; SMARCC1; DR1; NKX3-1; PSMD9; DDX5; NCOR2; HOXC6; RBBP7; RNF4; CBX3; MTDH; ZNF672; NELFB; ZBTB11; HSF2; HDAC2; KDM2A; NR2F2; CRK; UBE2B; TP53; HMGA1; AATF; ELF1; CTR9; SREBF1; BATF3; ETS2; NRIP1; COPS2; CTBP1; MAZ; HSBP1; DDX17; MED4; ZNF217; HMGB1; TBL1XR1; MED1; CARM1; CCNC; WHSC1; RNF138; EDF1; PUF60; DNAJC1; SSRP1; RUNX1; MEF2A; SMARCD2; DNAJC2; CENPB; NRBF2; NCOR1; ITGB3BP; COPS5; MLX; ZFP64; RBM39; SF1; CBX5; FOXD1; ID1; ARNTL2; PIR; RNF10; TBL1X; HMGA2; SUB1; IKBKAP; CNBP; ELK3; KLF6; CEBPG; SMARCA2; STAT6; PQBP1; RHOA; MBD2; BIRC2; RCOR1; KLF2; CCDC59; HOXA10; BRD3; BRD8; DEK; BAZ1B; KLF10; RREB1; PSIP1; TSC22D1; SCAND1; BRCA1; CNOT6; JARID2; TRIM16; HTATIP2; HDGF; ZMYM2; HMG20B; TRIM32; BCL11B; HOXC10; ZBTB1; HLTF; SUV39H1; TSC22D2; NFIL3; SPEN; IRX5; NFKBIA; PCGF2; KLF5; PITX1; HMGB2; WWTR1; KDM5D; TP63; RFX5; STAT5B; VGLL4; TRIM29; AFF1