Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17540 Alvocidib GSE70138 MCF10A Human 24h 10uM EID0021
Types Number Response transcription factors
Up-regulation 757 ERBB4; HOXD3; EGR1; ZNF556; ZNF91; HOXC8; ZFP2; SSX3; ZNF816; ZKSCAN4; PKNOX2; CBX4; PHF1; MECP2; ZNF132; ZNF391; ZNF442; SNAI1; ZNF257; ZBTB44; ZNF749; ZNF695; ZKSCAN8; ZNF253; ZNF467; ZNF492; ZNF350; HBP1; HOXA2; ZNF667; ZNF136; NFATC3; ZNF345; TFDP2; MYNN; HOXB8; SSX7; POU2F3; SRY; POU6F2; TBX5; ZNF770; ZSCAN2; FEZF2; WT1; ZSCAN18; ZNF273; ZNF93; WHSC1L1; HOXD1; ZNF549; ZBTB43; ZNF223; GLI2; ZNF780B; SCAI; LHX3; ATOH1; IKZF3; NRL; ZNF225; MED31; NEUROD2; SIX6; ZFPM2; KLF13; RFX1; THAP3; RING1; MYEF2; ZNF682; GRIP1; ZNF606; ZNF287; ZNF154; FOXL1; IFNB1; RFX3; THRB; NHLH1; GATA6; TFDP3; SCRT1; SOX21; HESX1; ZNF778; ZNF157; ASCL3; TULP1; SPI1; FOXH1; NEUROD6; ZSCAN16; IKZF2; TBR1; SOX5; PRDM13; NR1I3; NEUROG2; SOX3; CDX4; WNT4; EMX1; EP300; ZBTB3; ZNF264; TBX6; ZNF701; ZNF234; TBX1; BRDT; SOX18; SHOX; ALX4; VENTX; TWIST1; ZFP69B; ZNF81; ESRRB; TULP2; FOXE3; ZNF362; NFKB2; ZNF117; ZNF80; ID4; DLX2; UTF1; HOXD12; ZNF221; HNF4G; ZKSCAN3; ZIC4; TRIM24; BNC1; HDAC9; PPARD; IRF9; ZNF407; NACA2; ZNF214; PAX2; ZNF471; ZNF675; ZNF484; ATF7; NEUROD4; ZNF235; ZNF674; FOXJ1; ZNF426; CUX2; NAB2; ZNF208; HIC1; MYRF; HES2; PDX1; ZNF85; ZNF550; PRDM14; HINFP; ZIM2; MAPK8IP1; ALX3; TEF; FOXD3; HDAC6; PAX4; CARF; ZNF423; ZNF254; GSC2; ZNF506; TCF21; SUV39H2; SOX14; CREBL2; PRDM9; VGLL1; EN2; EZH1; ZNF571; HOXA6; SOX30; ZNF814; TBX21; ZNF343; CHD2; SSX1; ZNF589; POU1F1; GCM2; POU3F3; ETV3; SOHLH2; DCC; ZNF415; ZBTB7C; NR6A1; FOXI1; PRDM16; ZNF124; CBX2; THAP9; ZNF460; RFX2; OLIG2; GFI1B; ZNF573; ZNF440; ZNF493; TLX3; AEBP1; ZNF174; ZIC3; LMX1B; SALL2; SKIL; ZNF177; BNC2; GBX1; AFF3; SOX17; LMCD1; ZNF74; TUB; ONECUT2; MYF5; SMARCA1; ONECUT1; CIITA; CALCOCO1; ZNF557; PAX7; CAMTA2; MEOX1; ZNF586; VHL; ZNF665; TBX19; SOX1; PAX3; LIN28A; PROX1; CRX; SIM1; ZNF669; MAML3; TULP3; ZNF613; ARID3B; SP4; NKX2-8; MDM4; LZTS1; ZNF329; ZNF334; DBP; SOX2; MYCL; ZNF175; NKX6-1; TFAP2B; HOXB5; ZXDB; SP140; NEUROG3; HAND2; TAF1C; PRDM2; NFATC4; NR5A2; ASCL2; ZNF141; CDIP1; FHL5; BARX1; HOXB9; ZNF507; DLX6; POU4F3; POU4F2; GTF2A1; L3MBTL1; CBFA2T2; ZNF304; BCL11A; ZNF331; ZNF500; ZNF394; HDAC5; PEG3; NEUROG1; ZNF140; SUPT3H; HHEX; RBPJL; GBX2; NPAS1; CIR1; MXI1; POU3F4; PAX1; ZNF239; MEIS2; DOT1L; ZNF41; TAF4B; ZNF274; ZNF419; ZNF711; ZFY; ZNF155; FOXF1; KAT2B; ZSCAN9; ZNF623; MSX2; NCOA2; ZNF286A; ZNF180; SALL1; STAT2; ZNF512B; CSDC2; GATA3; ZNF222; HNF1B; TAF6L; ZNF134; TBX10; SUPT7L; NR4A3; ANKRD1; ZSCAN31; VAX2; NEUROD1; LMO1; PRDM1; ZNF652; NHLH2; LBX1; KLF15; MXD4; ST18; ZNF44; CCNH; ZNF142; ZNF232; FOXB1; SIN3B; POU6F1; HNF4A; KLF8; TP73; FOXL2; NR3C2; ZNF107; HEYL; SNAPC4; HOXB1; FOXE1; SSBP3; ZNF611; KDM5C; ZNF268; VSX1; HOXC5; MED12; THRA; ESR1; ZNF668; PRDM5; NR5A1; ZNF688; CCNE1; TBL1Y; ZNF813; ZNF551; ZNF250; RARB; ZNF835; MLLT1; NOCT; ZBTB6; NR2C2; HMBOX1; ZNF79; ESR2; REL; TGIF2; LHX6; GATA1; FOXD2; ZNF480; HOXD9; TCEA2; CREB5; HOXA3; LHX1; ETV2; BRWD1; ZNF135; YBX2; TBX4; HIF3A; ZNF224; ZEB1; TLX1; NR1H4; ZNF639; ZNF671; TAF7L; LHX2; ZNF43; AR; CBFA2T3; SKI; HOXC11; GCM1; PITX3; PROP1; LHX5; NFIX; ZBTB7B; MAK; BPTF; THAP10; ZNF536; ARID5A; ASH1L; RUNX2; TAF1; SHOX2; ZNF580; GFI1; ARRB1; PHOX2A; SAP130; SMAD6; ZNF654; NKX2-5; KLF11; NR1H2; CDX2; MSC; HABP4; ZNF587; AIRE; ZNF324B; ZNF14; ZNF215; RSF1; ARID5B; LZTR1; MED25; ZFP37; NANOG; CEBPE; PPARA; EYA3; FOXN1; ZNF528; RFXAP; CD3D; AFF2; NKX3-2; CERS4; RORC; CREM; RNF2; ZNF552; SIX3; OVOL2; TLX2; SRCAP; NR2F1; E4F1; FOXP3; HSF4; ZBTB39; RARA; ZNF529; NFE2; NFE2L2; HIPK2; FOXA2; ACTL6B; ZNF112; ZNF10; ZNF131; ZNF337; ING4; ZKSCAN7; ZBED2; NKX2-2; ZBTB17; FOXF2; SLC2A4RG; ZNF75D; PNRC1; RELB; ZNF184; KLF12; RARG; ATN1; TAF11; ARNT; NR2E1; ZFHX2; NFAT5; MYF6; HAND1; EHMT2; ETV6; CBL; DLX5; BACH1; NR0B2; RORB; LYL1; PRRX1; THAP7; HOXA4; FOXJ2; NR1I2; PRDM12; TSHZ2; SUPT5H; RXRG; TFAP4; BHLHE41; TCF4; NFKBIB; FOXC2; PBXIP1; STAT4; IRF7; E2F8; PCGF3; CDX1; ZNF771; TFAP2A; DMRT1; CBX7; IKZF4; HIC2; MYOD1; MAP3K10; TRPS1; ZBTB20; SIX5; HOXD13; FOXN3; RAX; ZNF202; ZBTB48; CRTC1; FUBP1; VPS72; ZFP30; ZNF430; OSR2; TOX; DYRK1B; PIAS4; CCNT1; ZNF211; PRDM10; NFE2L3; ETV1; TCF7L1; SOX10; EMX2; ZNF195; HOXC4; ATF3; TAF4; TFEB; PITX2; ZNF562; PRDM8; PTRF; TSC22D3; TCF7L2; IRF5; NR0B1; ZSCAN32; ZNF34; EPAS1; EHMT1; TEAD4; TCF7; FEV; PEX14; ZHX2; SPIB; OVOL1; BCL3; LITAF; BACH2; ARID3A; ELF4; SPDEF; ESRRG; MAFK; PLAG1; DLX4; THAP11; HDAC11; TLE2; HIVEP1; ZKSCAN5; CREB3L2; WWC1; ZNF8; MXD3; TERF1; MYT1; TONSL; EVX1; YEATS2; ZNF133; ZNF354A; MDM2; HIVEP3; ZXDC; MBD4; TGS1; MZF1; HEY1; EBF2; POU2F2; PBX1; KAT2A; BARX2; HLX; CRYM; SMAD9; ELK4; POU3F2; SOX11; ZIC1; ETS1; ZNF12; E2F1; NFIC; CAMTA1; TAF6; TAL1; KLF9; MEIS1; ZNF532; GATA4; GRHL2; CDK9; CITED1; ZMIZ1; SOX12; ZNF248; ZNF33B; SP140L; CEBPD; SP2; KLF1; FOXO4; CNOT3; PHIP; BANP; MYBL1; TEAD3; CDYL; NR4A1; E2F4; HLF; POU5F1B; ZNF160; MXD1; JAK2; MYCN; TCF3; IRF3; PAX6; PAX8; HOXB2; IRF4; HEY2; ZNF444; KLF3; PBX2; ISL1; PAXBP1; SOX13; JUN; ZNF768; ZNF200; YEATS4; PGR; SSBP2; TEAD1; MNDA; EN1; TGFB1I1; CNOT2; HOXB6; EGR2; RBBP8; MEF2C; ZFHX4; PBX3; ZNF226; TGFB1; MEOX2; IRF8; ARNT2; IRF6; FOXG1; RORA; TFEC; ID3; NR4A2; ZNF721; GATA2; INSM1; CALR; INSR; FOXO1; DACH1; TXNIP; TGIF1; ZMYND8; BRD4; FOS; TBX2; BBX; TCEA1; HIRA; PAWR; IL16; TRIB3; CBX6; TRIM22; TFAP2C; MECOM; LOXL2; IFI16; E2F2; ING3; JUP; DMTF1; TBX3; PLAGL1; ASCL1; IKZF1; LEF1; CREB1
Down-regulation 173 USP22; FOSL1; MYC; CCNA2; CRK; FHL2; TCERG1; HDAC1; TRIM28; GTF2A2; RBM14; TBP; FOXJ3; NUP62; EZH2; CREG1; RBBP4; YWHAB; MED6; RUVBL2; UBE2I; BASP1; TFDP1; NCOA4; HOXA10; HDAC2; NACA; ADRB2; SMARCC1; YBX3; MED24; NRIP1; PTTG1; CDK7; HDAC7; BCLAF1; HMGB1; ATF6; ATF1; RAN; PA2G4; TRIP6; BAZ1A; NONO; BTF3; BMI1; NPM1; TBL1XR1; C1QBP; AATF; VGLL4; YBX1; STAT6; XRCC6; ELK1; ILF2; PMF1; GABPB1; ENO1; HDGF; NELFB; NFKBIA; HOXB7; UBP1; MAX; KAT5; NEDD8; RNF6; CBFB; BRD8; SMARCE1; TCF12; CBX5; CCNC; ZNF146; HMGA1; RNF14; HOXC6; RBBP7; CENPF; ETS2; HSF2; CTR9; SFPQ; HNRNPD; MLX; CNOT1; CARM1; ELF1; TRIM32; USF2; CTNNB1; PSPC1; WHSC1; HMGB3; CNOT6; PRKDC; MED23; SSRP1; HSBP1; PPRC1; MTDH; MAZ; ORC2; SMARCA2; TSC22D1; SAP30; TFAM; NKX3-1; FOXD1; MBD2; RHOA; CTBP2; PHF2; ATF4; UBE2B; CEBPZ; APEX1; ZBTB11; ECD; SMARCA5; RNF4; SNW1; CENPB; RCOR1; SIAH2; SMARCD2; TAF9; BRD3; NFIL3; ELK3; SREBF1; PATZ1; NCOR2; ZNF410; TLE1; CBX3; TAF10; EGR3; EDF1; FLNA; IKBKAP; BCL11B; TRIM16; TP63; PURA; KAT7; HOXA5; PCGF2; PSIP1; NFIB; ZMYM2; RREB1; HMGA2; VEZF1; JARID2; PUF60; SMAD2; RNF10; KLF2; PIR; SUV39H1; HLTF; XBP1; MED1; AFF1; RUNX3; BTG1; RFX5; TSC22D2; HMG20B; MYBL2; ID1