Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17443 Azd-5438 GSE70138 MCF10A Human 24h 10uM EID0020
Types Number Response transcription factors
Up-regulation 682 EGR1; ERBB4; ZNF345; THRB; ZKSCAN4; SOX17; TBX6; WHSC1L1; FEZF2; ZNF331; ZNF154; ZIC4; SSX7; CREBL2; ZNF117; RFX3; ZFPM2; ZNF132; ZNF254; ZNF467; ZNF695; PRDM9; ASCL3; ZFP2; ZBTB44; ZKSCAN8; ZNF492; ZNF816; CHD2; ZNF257; TBX4; ZNF682; ZNF768; SCAI; MAML3; NEUROD4; AFF2; SOX3; ZNF91; TLX1; NR1H2; RING1; ID4; SOX18; ZKSCAN3; ATOH1; ZNF667; SHOX; EMX1; TBX5; DLX5; CIITA; ZNF208; ZBTB3; CARF; IKZF2; PROP1; ZNF85; ALX3; FOXE3; ZNF221; HOXA3; NR5A1; ZSCAN9; TBX2; POU6F1; ZNF223; NR5A2; POU2F3; RFX1; NFATC4; DCC; ATF7; CBFA2T3; MECP2; PRDM14; ZSCAN2; SSX3; HES2; NEUROD2; EYA3; ZNF507; NOCT; ZNF253; TAF1C; ING4; MEF2C; BRWD1; PAX4; TBX1; ZNF136; LHX3; ZNF814; CRX; SPI1; LZTR1; SOX5; MYCL; ONECUT2; ESRRB; ZNF442; POU6F2; ONECUT1; TRPS1; ZNF549; NR2E1; ZNF471; ZNF235; GRIP1; RFX2; KLF8; ZNF440; HOXD12; ZNF81; CALCOCO1; SRY; ZNF180; POU3F4; ZNF749; NKX2-5; NEUROG2; TBR1; PRDM1; ZNF362; NPAS1; ZNF225; ETV3; ZNF157; MED25; ZNF350; ZSCAN18; GCM2; SP4; ZNF493; ZNF550; DLX6; POU1F1; THRA; NEUROG1; ZNF674; PAX2; PKNOX2; ZNF665; ZNF780B; PRDM5; ZNF135; ZNF391; SNAI1; ZNF407; ZNF273; SOX14; BARX1; NHLH1; ZNF80; SCRT1; HOXB1; ZNF536; ZNF701; IRF9; IRF6; TWIST1; SIX3; ESR2; REL; HOXC8; BCL11A; HOXB8; NR6A1; VENTX; CAMTA2; TULP1; ARID3B; HIF3A; MED31; HDAC5; PAX1; ZNF506; ALX4; MEIS2; MDM4; GSC2; AFF3; ZNF75D; LBX1; CCNH; NEUROG3; BNC1; ZIC3; SALL1; ZNF214; GATA2; RBPJL; RORB; DLX4; TFDP3; TP73; ZNF10; HOXD3; HAND2; HNF4G; ZNF675; SALL2; PDX1; HEYL; ZNF770; NRL; ZNF606; ZNF500; ZNF141; CSDC2; FOXP3; ZNF177; RARG; ZNF623; HSF4; ZNF74; ZIM2; MAK; CDX4; VHL; HOXA6; TUB; NR4A3; MSX2; CBX2; NEUROD6; OLIG2; ZNF557; MBD4; DLX2; ZNF264; GBX2; SKI; IKZF3; ZNF343; HIC2; PAX3; LEF1; ZBED2; SIX6; FOXI1; EP300; ZNF671; PRRX1; CDX1; GBX1; ZNF556; NFIX; ZNF562; HOXC5; HNF1B; CBL; HLX; ZNF426; E2F8; ZNF43; ZNF287; POU3F3; ZNF155; VGLL1; CEBPE; TCEA2; ZNF93; E2F1; HNF4A; SOX1; ZNF669; ZXDB; NKX3-2; NR4A1; NFE2; DYRK1B; GLI1; FOXH1; TFAP4; HESX1; CD3D; PAX7; MAPK8IP1; ZNF304; LMX1B; SOHLH2; ZNF613; CUX2; ZNF274; ZNF571; PRDM12; MLLT1; ZNF484; ZNF529; HOXB5; ZNF423; SKIL; ZBTB7B; HOXD13; ZNF14; PPARA; HOXA2; CBX4; NKX6-1; CDIP1; ZNF175; FOXN1; TAF6L; DOT1L; PRDM2; ZNF234; DMRT1; ZFHX2; BRDT; TFAP2B; TULP2; ST18; TBX10; ARL2BP; ZFHX3; ZNF778; TEF; TBX21; TONSL; ZNF611; AEBP1; POU4F3; TSHZ2; PEX14; UTF1; ZNF710; CBX7; LHX6; SHOX2; ZNF573; RXRG; SUPT3H; ZNF286A; TLX2; THAP9; SOX21; MAFK; ZNF222; ETV2; AR; ZNF268; FOXD3; ESRRG; L3MBTL1; ZBTB43; BPTF; PBX2; SIM1; NR4A2; POU3F2; PRDM16; FOXJ1; WNT4; ZNF41; MYNN; NFKB2; ASCL2; ZBTB48; MED12; E4F1; ZNF711; AIRE; ZBTB7C; HBP1; NR1I3; RAX; TAF7L; MXD3; EVX1; ZNF232; IFNB1; BNC2; ATF6B; HIC1; MDM2; GRHL2; NR1H4; ETV7; IKZF4; HOXB13; FOXB1; TULP3; ZNF250; STAT2; ZNF140; MYEF2; EZH1; ZNF544; FOXC2; ZFP69B; PRDM13; ZNF444; ZNF107; TCF4; YBX2; E2F4; GCM1; MYCN; ZNF184; HMGXB3; ZNF33B; ATF3; FHL5; SSBP3; ZNF415; NHLH2; ZNF79; ARID5A; ZBTB39; ZNF224; ZNF334; ZSCAN16; ZNF835; ZNF134; TLX3; PITX3; MXI1; SUPT7L; GFI1B; MYF5; HHEX; ZNF174; ZNF142; ZNF34; ZNF124; MEOX2; NEUROD1; ZNF215; FOXF1; ZNF195; SMAD6; FOXL1; LMCD1; SSX1; TFEB; KDM4C; RORC; CNOT3; ZNF44; KLF3; POU4F2; TAL1; ZNF358; ZXDC; NKX2-8; NACA2; PHOX2A; ZNF652; KAT2B; WT1; OSR2; CRTC1; TEAD3; ZNF460; PNRC1; NFAT5; KLF15; JUN; HAND1; SP2; VAX2; CIR1; ZNF430; CERS4; ZSCAN31; SIX5; KLF13; KMT2D; KLF7; HDAC9; RSF1; TGIF2; NAB2; ZNF654; BHLHE41; ACTL6B; CBX8; BAZ2A; THAP7; PHF1; TCF21; EBF2; ZNF8; GATA6; MED15; ATN1; OVOL2; MEOX1; ZNF551; LYL1; CDX2; ZNF419; CUX1; HIPK2; ZNF219; MZF1; CRYM; RARB; SUPT4H1; FOXF2; ZNF205; CREM; HEY1; ZNF394; BACH1; EN2; OVOL1; BARX2; ZNF112; MYF6; SRCAP; APBB1; ZKSCAN7; MECOM; ESR1; NR3C2; ZNF688; ZNF771; FOXJ2; ZNF587; CREB5; ZNF329; TLE2; HMBOX1; EHMT2; PIAS4; POU2F2; HINFP; HOXD1; ZKSCAN1; FOXN3; TTF2; TBX19; TRIM24; CAMTA1; CEBPD; EMX2; ZBTB17; ZNF552; TCF7L2; PRMT2; ARRB1; MYT1; BRCA2; FOXE1; JAK2; NANOG; JUP; LIN28A; TFEC; GLI2; LMO1; AES; TFAP2A; ZEB1; BRF2; PRDM10; KDM5C; ZNF239; FLI1; ZFP37; ZNF354A; SP140L; ELK4; BACH2; SMARCA1; ARID3A; HEY2; ZNF200; ZNF165; EYA1; THAP10; NFIC; MEIS1; PROX1; FOXL2; ZBTB6; BIRC2; GFI1; DBP; EPAS1; KLF11; LHX2; HIRA; PLAG1; IRF5; TCF7L1; CREB3L2; SNAPC4; SOX2; HLF; MED14; PBXIP1; ARID5B; PEG3; ZNF468; MNDA; TCF7; NR0B2; WWP1; GATA1; PAX6; ARNT2; SUMO1; INSM1; NFE2L3; INSR; TGFB1; KLF9; SMARCC2; RERE; TRIB3; MSX1; NCOA2; HOXB2; ZFY; ZNF211; ZNF12; ZNF22; TFDP2; FOXG1; SATB2; VPS72; PITX2; TLE4; FOXA2; DACH1; FOSL2; ZBTB20; TCF3; CHD9; MITF; HOXB6; BAZ2B; NKX2-1; EGR2; SP100; TRIM22; PBX3; RORA; PHIP; ZEB2; TOX; TBX3; ID3; SOX13; NR1D2; EGR3; PLAGL1; MAFF; ZIC1; ZNF532; ZHX2; MYBL1; NKX2-2; ZNF586; RBL2; TXNIP; EHF; IRF8; SOX11; VDR; ZNF512B; MYRF; SMAD7; LITAF; MAFB; SPDEF; ZNF589; CALR; FOS; MAF; ASCL1; NFATC3; NR2F1; E2F2; SSBP2; SNAI2; CREB1; SATB1; IKZF1
Down-regulation 182 CCNA2; TCERG1; NUP62; USP22; MYC; FHL2; NFKBIA; CRK; ATF6; FOSL1; ADRB2; TBP; RBM14; NRIP1; EZH2; HNRNPD; SUV39H1; HDAC2; CENPF; HOXA10; RBBP4; CDK7; SNW1; BAZ1B; NFIL3; UBE2I; SMARCC1; AATF; HOXA5; SMARCE1; PTTG1; SF1; KDM2A; RAN; TRIM28; PARP1; RNF4; UBP1; TRIM32; CBX3; NCOA6; SFPQ; ATF1; ING2; ELF1; BRCA1; TRIM16; DNAJC2; CTR9; SMARCA5; BCLAF1; DDX54; BRD8; NELFB; PA2G4; PPRC1; SSRP1; ECD; BMI1; HMGB2; DR1; MED6; TBPL1; PMF1; SREBF1; PHF20; YWHAB; ZNF146; NFIB; NPM1; BAZ1A; KLF6; NONO; JARID2; ATF4; ZMYM2; DEK; RBBP7; PATZ1; NCOA4; TP53; CNOT1; MED1; HOXC6; HDAC1; CNOT6; TBL1XR1; HOXB7; PUF60; XBP1; RBM39; APEX1; NFKB1; BRD3; TBL1X; KAT5; PCGF2; EDF1; CEBPZ; ZFP64; EED; RFX5; VEZF1; WHSC1; USP21; ERBB2; XRCC6; RFC1; TFAM; BRPF1; HLTF; YAF2; C1QBP; ASXL1; ITGB3BP; ZBTB24; ILF2; HSF2; MTDH; RREB1; MED24; RUVBL2; YBX1; YBX3; SCAND1; MBD2; RBPMS; RNF138; BASP1; BLM; RNF6; ENO1; MTA1; FOXJ3; HDGF; HMGB1; PRKDC; CBX5; NR2F6; CTBP2; PRPF6; SAP30; PITX1; ATF5; ELK3; HMGB3; FOXK2; TCF12; GATAD2A; CDYL; ZBTB18; ADNP; MAX; SIAH2; DDX5; CRY1; PIR; CEBPG; AFF1; TSC22D2; ARNTL; SMAD2; ABL1; DNMT3B; NR2F2; SERTAD2; TRIP6; HMGA1; NRBF2; PURA; BTG1; FLNA; ZFP36L1; NKX3-1; KDM5D; MYBL2; ZBTB38; IRX5; TOB1; CITED2; MAGED1; SOX9