Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17419 Afatinib GSE70138 MCF10A Human 24h 0.12uM EID0020
Types Number Response transcription factors
Up-regulation 263 TSC22D3; NFKBIA; ADRB2; RFX5; ZNF768; SOX4; FOXO4; HDAC5; CALCOCO1; PNRC1; PBXIP1; ING4; VGLL4; TRIM29; CREBL2; ZFHX3; BPTF; TEAD3; TP63; TBX6; NR5A1; ZBTB3; ZKSCAN4; TRIM22; MECP2; ARHGAP35; ZNF358; MEIS1; ARID4B; AFF2; RARB; DLX4; OSR2; WNT4; RARG; ID2; ZNF268; IRX4; CSDC2; GCM1; ARID5A; ZNF493; SMAD6; TBX5; KDM4A; CREG1; ZNF688; REL; RXRA; ZNF254; TSHZ2; SOX17; TBX1; ZNF492; MNT; SRCAP; CDIP1; FOSL2; SIX3; PLAG1; MAML1; ZBTB7C; TRIM16; FEZF2; MZF1; ZNF611; RING1; CEBPD; E2F5; BNC1; THRA; ZMIZ1; OVOL2; GLI1; ZNF629; BRDT; AR; CIC; FOXO3; TCF7L2; CARF; ZNF467; ZBTB44; NCOA2; ZNF214; DYRK1B; ZSCAN31; ELF3; FOXJ1; MYF5; CBFA2T3; ZNF529; SIM1; NHLH2; MED25; ZNF665; SUPT7L; SOX3; MDM2; SALL1; ZNF160; SOX12; NFE2L1; MYCN; TLE2; TOX; HIVEP1; HOXB13; ZNF14; CUX1; IRF6; ZBTB43; PPP1R13L; ESRRA; DLX5; NFKB2; FOXN3; SCAI; VGLL1; TADA3; ZNF444; CIR1; SREBF2; JUP; ZNF33B; NR5A2; BTG1; IRF9; KDM4C; ZHX2; AES; SMARCD2; HIF3A; EHMT2; EP300; PDLIM1; INSR; HINFP; ZNF711; HESX1; SIX5; ZNF195; ZNF354A; KAT2B; PRDM2; ZNF219; ZNF117; VAX2; TGIF2; HIC2; MECOM; TRIM24; HBP1; MED24; BCL6; ZNF669; TRPS1; HAND1; MEIS2; HOXB1; FOXI1; RNF10; MEN1; EHF; ERBB4; PBX1; ERBB2; BCL11A; ZNF652; SREBF1; ZFY; OLIG2; ZNF587; ZNF667; SIRT2; ZNF44; ISL1; MED12; TFAP2A; NR1H4; PEG3; ZNF165; TCF7L1; ID1; ZNF264; ZNF536; SP3; CHD3; CERS4; HSF1; TP53; EPAS1; ZIC3; SSBP3; ZNF423; FOXF2; CBX7; BACH2; NFIC; TFAP2C; TFDP2; ZIC1; TCEA2; NAB1; TCF25; HMBOX1; FOXF1; TFEC; CUX2; ATN1; DBP; SCAND1; ID3; SALL2; TLE1; MXI1; TCF12; GATA6; ZNF304; KLF11; SIAH2; BCL3; BRD4; ZNF350; IRF1; HDAC9; ELF4; LITAF; SNAI2; GLI2; ZNF415; ZBTB16; HIRA; ZSCAN18; TSC22D1; BRD2; SMARCD3; TCF4; HOXD1; ARNT2; HMGN3; EMX2; ZNF331; ZNF532; SMAD7; JUND; ZNF217; ZFP36L2; KLF5; HTATIP2; TCF21; NR0B1; ATF3; CRYM; MAF; TXNIP; MYRF; DACH1; ARID5B; BASP1; ESR1; KDM5D; SSBP2
Down-regulation 98 CCNA2; FOSL1; BRCA1; SUV39H1; EZH2; CDK2; FHL2; HMGA2; CENPF; TFDP1; NUP62; TCERG1; RUVBL1; PA2G4; MYBL2; HMGB2; BCLAF1; CHAF1B; PARP1; DRAP1; PTTG1; MTF2; UBE2I; HDAC2; ITGB3BP; C1QBP; PSMC3IP; EGR1; DEK; TAF1A; FOXM1; RBM14; BATF3; HOXB7; RAN; SSRP1; XRCC6; CAPN15; PREB; ZNF200; EGR3; NFIB; HNRNPD; MBD2; KMT5A; ILF2; NPM1; RUVBL2; GTF3A; ETV4; CRY1; BAZ1A; HOXC6; KLF6; RNF4; HMGB1; CBFB; EED; AATF; TFAM; HSF2; ING2; YWHAB; TCFL5; SATB2; EDF1; RNF138; BMI1; ING3; RBBP4; XBP1; ELK3; TRIM28; SAP30; CCNE1; PRKDC; PURA; TBL1XR1; SFPQ; SUB1; WWTR1; ETV5; MAFF; ENO1; HLTF; MTDH; DNMT3B; FOXD1; DLX2; HOXB2; MAGED1; HOXB6; SOX9; HOXC10; PPARG; PBX3; MAFB; EGR2