Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17416 Afatinib GSE70138 MCF10A Human 24h 3.33uM EID0020
Types Number Response transcription factors
Up-regulation 387 TSC22D3; ZNF274; CREBL2; ZNF345; ZNF768; ZKSCAN4; ING4; ZNF665; ZNF135; NR5A1; ZNF44; ASCL3; ZNF667; SOX4; ZSCAN9; CSDC2; ZNF91; ZNF14; PNRC1; FOXO4; THRB; ZNF132; TBX6; ZNF254; EPAS1; SOX3; SCAI; ZKSCAN3; VGLL4; TBX4; CARF; ZKSCAN8; CALCOCO1; ZFHX3; TRIM29; ZNF611; ELF3; MAML3; ZNF544; OSR2; ALX3; CBX7; AFF2; RING1; RFX3; HDAC5; ZFPM2; ZNF492; FEZF2; SOX17; ZFP2; EHF; ZNF362; CIITA; IRF6; ZNF43; ZNF304; TAF1C; ZNF529; ZNF223; ZNF816; ZNF136; SSX7; CIR1; RARB; ZNF154; ZBTB3; ZNF334; ZNF471; ESR2; ZNF606; ZKSCAN1; ZNF225; ZNF74; MZF1; MXI1; ZNF257; HOXB3; ZNF33B; RARG; CRX; PRDM9; CHD2; CBFA2T3; NR1H2; ZNF426; ZNF835; WNT4; ZNF814; TFEC; ZNF268; ZNF682; MEIS1; ZNF749; ZNF701; ZNF350; ZNF331; TFAP2A; MYCL; MEF2C; VGLL1; ZNF669; ZNF652; ZFHX2; ZNF81; MYF5; THRA; OLIG2; ZSCAN31; ID2; SOX18; ESRRB; ZNF253; ZNF688; PKNOX2; ZNF224; TRIM22; EMX1; ZNF337; ZNF264; ZNF695; NHLH1; HNF4G; HIF3A; CDIP1; SIM1; HBP1; CBFA2T2; DCC; TBX5; SIN3B; DYRK1B; TULP2; ATOH1; HOXB1; NR1H4; NHLH2; ARHGAP35; ZNF675; PRDM2; ZNF250; PROP1; ZIM2; NEUROD2; PRDM12; RORC; KAT2B; ZNF536; ZNF506; AR; ZNF358; ATN1; NR5A2; HINFP; TCEA2; TP73; ZNF83; TRIM16; ZNF419; ZNF160; ZNF778; POU2F3; ZNF214; ZNF235; ZNF34; ZNF510; PAX1; ZNF354A; ZNF444; ZNF500; ZNF571; ZNF141; ZBTB44; BRWD1; ZNF623; TBX1; FOXI1; MAK; BCL11A; ZNF85; NFATC4; MEIS2; SOX5; GRHL2; SETDB1; VENTX; TCF25; NEUROD1; TAF6L; TP63; GBX1; PBXIP1; E2F5; SP2; ZNF467; ELF4; POU6F2; TEF; ERBB4; CBX2; SUPT7L; CEBPD; ZNF75D; PRDM14; ZNF573; MLLT1; TEAD3; ZNF155; HDAC9; SMAD6; ZNF117; TOX; DLX4; MECP2; SIX5; ZNF219; HESX1; TULP1; GBX2; INSM1; L3MBTL1; RFX2; JUP; ZIC1; KDM4A; SP140; GATA6; ID4; BPTF; STAT2; ZNF134; ZMIZ1; SOX12; SRY; HIPK2; EHMT2; ZNF175; HOXD1; ACTL6B; ZNF215; TXNIP; TSHZ2; ZNF93; ZNF112; LHX3; ZNF140; ZNF329; FOXO3; TBX10; TGIF2; ZSCAN18; MAPK8IP1; ARID5A; EZH1; ESRRG; ZNF124; EMX2; ZNF430; CERS4; ZNF711; SRCAP; ZNF222; ZNF133; SALL2; ZSCAN16; NR0B2; PEX14; BTG1; ZNF10; BNC2; ZNF184; ZXDC; ATF3; ZBED2; ZNF671; ZIC3; JAK2; ZNF195; TFAP2C; EN1; IRF9; SIRT2; HOXB5; SIX3; RSF1; AHR; HOXB13; ZNF551; FOXJ1; ZNF415; ZFP36L2; TRIM24; PBX1; ZBTB43; BCL6; ZNF423; PHF1; DLX5; HMBOX1; NR4A3; ZHX2; OVOL2; CHD4; IRF1; ZKSCAN7; MECOM; FOXK2; NCOA3; TCF7L2; ID1; BAZ2B; FOXN3; SOHLH2; ZNF468; PDLIM1; WT1; ARNT2; PHF20; SP140L; BHLHE41; TRPS1; NCOA2; ZNF211; RXRA; FOSL2; FOXF2; ZNF165; AES; TCF7; PEG3; ZMYND8; HIC2; POU2AF1; ZNF580; TFCP2L1; SHOX2; SNAI2; HOXB2; CRYM; ZNF512B; ST18; LITAF; THAP10; TAL1; NFAT5; HEY2; MEOX2; DDX17; PIR; EYA1; PPARGC1A; HLX; BATF; MYRF; ERBB2; FOXF1; NANOG; INSR; KLF5; HLF; MYT1L; TOX3; TLE1; HOXB6; KLF13; TRIB3; JUND; TCF21; HEY1; MAF; CD3D; ID3; SSBP2; FOXO1; ASCL1; BRD2; SOX11; IRF8; KLF4; ESR1; ZBTB20; TSC22D1; TCF4; SOX2; ARID5B; ZNF586; GLI2
Down-regulation 115 CCNA2; FOSL1; HMGA2; SUV39H1; BRCA1; TCERG1; EZH2; FHL2; CENPF; PARP1; EGR1; TFDP1; DRAP1; MYCBP; HNRNPD; RBM14; RUVBL1; NUP62; BCLAF1; HMGB2; PTTG1; C1QBP; MYBL2; XBP1; FOXM1; GTF2A2; GABPB1; ETV1; RHOA; SUB1; TAF9; WDHD1; BAZ1B; PA2G4; CBFB; HMGB1; NFKB1; WHSC1; BLM; HOXA1; NPM1; DR1; ITGB3BP; PSMC3IP; SNW1; C1D; BMI1; TFAM; ETS1; PPRC1; CBX5; RBBP4; MTF2; HLTF; EGR3; SMARCA5; JARID2; EDF1; DEK; BATF3; YWHAB; ORC2; RUVBL2; SFPQ; NFIB; ING2; SUZ12; STAT3; AATF; PURA; CARM1; DNAJC2; MSX1; ETV4; RAN; PRKDC; ENO1; KMT5A; UBE2I; FOXD1; TRIM28; EED; CCNE1; CTR9; PITX1; ELK3; BAZ1A; PMS1; RNF138; YEATS4; CEBPZ; ING3; HOXC6; SIM2; RBBP8; SMAD3; KLF2; MNAT1; EGR4; TSC22D2; KLF6; SAP30; HMGA1; BHLHE40; MYB; HOXB7; DNMT3B; TBL1X; ZFP36L1; WWTR1; SMAD1; KDM5D; EGR2; SOX9; NR2F1