Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17097 Alvocidib GSE70138 MCF10A Human 24h 3.33uM EID0019
Types Number Response transcription factors
Up-regulation 738 ZBTB44; ERBB4; ZSCAN2; ZNF345; MEIS2; TAF1C; ZKSCAN4; EGR1; PROP1; HOXB1; MAML3; NFATC4; CUX2; CDX4; RFX1; TBX6; ZNF154; VGLL1; SCAI; VENTX; ZNF235; TP73; RBPJL; ZKSCAN3; KLF13; LHX3; ASCL3; PRDM14; EMX1; AFF2; SPI1; SALL2; DLX6; CRX; HOXC8; LZTR1; SHOX; POU6F2; ZNF500; HESX1; EP300; NR0B2; NEUROD4; ZNF589; TULP1; THRB; ZNF180; ONECUT1; ZNF75D; TBX5; FOXE3; NR5A1; PRDM12; TFDP3; TAF6L; ESRRB; ALX3; ZNF221; KAT2A; TUB; PRDM9; PDX1; ING4; NPAS1; NEUROG2; ZNF695; PHF1; ZNF814; CIITA; CHD2; RARG; NFATC3; ZNF117; SOX21; ALX4; RING1; CBX2; MED25; CALCOCO1; FOXH1; SOX3; ZNF467; ZNF362; BNC1; ZNF701; ZNF223; SRY; LIN28A; ZNF771; HES2; DLX5; FEZF2; HOXB8; HNF1B; THAP3; NR1I3; NEUROG1; DOT1L; ZFHX2; TGFB1; NR6A1; TLX2; SIM1; NEUROG3; FOXL1; HOXD3; DCC; NAB2; NOCT; ZNF124; NEUROD2; CEBPE; PRDM16; RFX3; BARX1; SOX17; ZNF816; HEYL; POU3F4; ZNF768; GBX1; SIX6; HBP1; NKX2-5; PITX3; SIX5; SOX18; EZH1; FOXP3; ZIM2; HAND2; LMX1B; TEF; ZNF440; HOXD12; HOXA3; NRL; SCRT1; ZNF132; AR; ZSCAN9; NEUROD6; POU4F3; ETV3; PAX1; DYRK1B; MYF5; ZNF507; GRIP1; MYCN; MZF1; HDAC5; ZNF682; ZNF669; ZNF358; ZNF268; ZNF136; ZNF778; ESR2; E2F4; PAX7; E2F1; MLLT1; SSX7; ZNF667; BRWD1; MEIS1; CDIP1; SUPT7L; NR5A2; KLF15; CBX4; KAT2B; ZNF81; TSHZ2; IKZF4; ZNF112; POU2F2; PAX2; ZNF225; ZNF623; ZNF749; ZNF549; POU3F3; ZBTB7B; SOX1; TCEA2; HIC1; ZBTB3; MYNN; RSF1; ZNF222; ZNF350; SOX5; HOXC5; HIF3A; CARF; ARID3B; PEX14; TULP2; MAP3K10; ZNF343; SRCAP; ZNF471; ZNF79; AIRE; MAPK8IP1; GSC2; NHLH1; ZNF215; HMBOX1; EVX1; E4F1; FOXD3; ZNF331; HOXD1; AFF3; PRDM2; SP4; PRDM1; RAX; NKX2-8; ZNF197; TWIST1; SNAPC4; MAFK; TFAP2A; NKX6-1; HIVEP3; IRF5; ZBTB48; SNAI1; SOX14; PRDM10; MED31; ATF6B; RFX2; ATF7; SSX3; ZBTB7C; ZNF442; FOXN1; KLF8; CIR1; NKX3-2; HSF4; ZNF80; IRF9; HNF4G; POU2F3; TBR1; ETV2; NFKB2; GBX2; MECP2; HOXD13; LBX1; MBD4; TONSL; EPAS1; FOXI1; ZNF512B; HOXA6; ZNF257; ZNF391; TBX1; FOXJ1; IFNB1; MYT1; TBX10; SIX3; ZNF254; THRA; SKI; ZNF674; ZKSCAN8; ZNF688; APBB1; ZNF536; RORB; ZNF76; LMO1; TULP3; POU1F1; POU6F1; WNT4; ETV7; ZNF155; ZNF93; IKZF3; TLX3; PHOX2A; ZNF780B; HNF4A; PAX4; ZNF493; VSX1; MXD3; PAX3; WT1; ID4; KMT2D; NFAT5; FOXB1; ONECUT2; GCM2; CERS4; ZNF407; IKZF2; KDM5C; ZNF250; ZNF484; ZNF611; ZNF74; ZNF550; CBX8; ZNF668; ZNF606; ZIC4; DBP; TBX4; CAMTA2; PRDM8; OVOL1; ARID5A; ZNF224; TBL1Y; ZIC3; PRDM5; BRDT; ZNF142; ZNF234; TFAP4; TLX1; CREBL2; MSX2; OLIG2; SOX2; ZBTB17; ATOH1; ARID3A; ZFP2; ZNF573; PRMT2; TBX21; GCM1; ARNT; ZNF214; BPTF; ZNF639; ZNF408; CSDC2; ZNF770; CIC; BNC2; ZFHX3; ZNF157; ZNF423; PKNOX2; BCL11A; STAT2; VHL; HOXB5; CBX7; MXD4; GFI1; HDAC9; CNOT3; ZNF671; ARHGAP35; RUNX2; ZXDC; ZNF219; GATA6; SREBF2; SOX12; HIC2; HDAC11; VPS72; ZNF91; HINFP; ZNF415; ZNF12; ZNF557; ZSCAN18; ZNF444; THAP9; ZNF264; HAND1; ZNF41; LDB1; ZNF140; ZNF175; ZNF304; JUP; RFX5; PNRC1; HHEX; SIRT2; ZNF195; DMRT1; ZNF205; MYCL; MDM4; ZXDB; ZNF324B; DLX2; FOXC2; HLX; FOXD2; NFIC; ZNF34; EYA3; POU5F1B; LHX5; BARX2; NR4A3; ZNF35; ZNF329; CD3D; PPARA; MAK; EHMT1; MXI1; ZNF208; ZNF492; ST18; MED12; ZNF835; HOXD9; FOXJ2; ATN1; ZFPM2; TRPS1; TFAP2B; VAX2; ZNF711; AEBP1; ASH1L; ARL2BP; WHSC1L1; L3MBTL1; ZNF14; SMAD6; E2F2; LHX2; SMAD9; RORC; ASCL2; ZNF287; ZNF85; MNX1; CREB3L2; LMCD1; MYEF2; ZNF580; CBFA2T3; HOXB3; SSBP3; NACA2; GMEB2; EHMT2; THRAP3; ZNF135; ZNF174; TRIB3; NFIX; TGIF2; DAXX; SKIL; ZNF276; ZBTB43; DLX4; PHOX2B; ZSCAN32; KLF7; MECOM; HMGXB3; TFEC; IRF6; CREB5; FUBP1; TBX19; GRHL2; RXRB; NR2E1; SP140L; GFI1B; ACTL6B; ZNF107; ARNT2; PBX2; ZNF665; GTF2A1; ZFY; ZKSCAN7; GATA1; ZBTB39; SUMO1; FHL5; PBX3; TEAD3; ZNF141; PBXIP1; SHOX2; CALR; HSF1; PRDM13; ZNF613; HNF1A; TCF21; TAF1; CBFA2T2; ZFP37; RARB; SUPT4H1; POU3F2; BAZ2A; ZNF446; SMARCD1; LYL1; ZNF646; ERF; HMX1; UTF1; TAF7L; CBX6; ZNF556; SMARCA1; ZSCAN31; ZNF529; SP140; FOXE1; GLI1; NR1H2; ATF2; BRF2; MTA2; ZNF506; ZNF253; MYRF; TCF7L2; CRTC1; HIPK2; ZNF562; ZNF239; HEY2; ZNF675; ZNF286A; ZNF354A; ZNF148; SOHLH2; MAFB; CHD9; ZNF8; ZNF334; RXRG; ZNF460; FOXL2; ZNF551; MNDA; HOXC13; GLI3; ZFP69B; HEY1; ESRRG; ZNF10; HIVEP1; PRRX1; ARRB1; BAZ2B; RELB; SUPT3H; BRD2; OVOL2; ZSCAN16; ZNF232; PHIP; ZNF710; SUV39H2; CDK9; ZNF160; ZBTB6; ZNF654; KDM4A; TRIM22; HMGN3; CNOT2; ZNF419; LHX6; ATF3; SLC2A4RG; ZNF652; PEG3; IRF3; NHLH2; BACH1; CERS6; TRIM24; NLK; CDX1; HIPK1; TCF4; PCGF3; ESR1; RBFOX2; LHX1; ZBTB20; ZNF248; ZNF211; CCNT1; FOXF2; ZBED2; TAL1; SOX10; LZTS1; ZNF532; MED14; ZNF134; CREBZF; CAMTA1; ARID5B; ZNF426; TOX3; TFAP2C; GLI2; EMX2; MSC; POU4F2; CDX2; MKL1; NANOG; SMARCC2; PGR; ZNF184; HOXA2; KLF3; NKX2-2; HIRA; EHF; AES; DMTF1; EN2; TCF15; SALL1; ZNF83; HLF; NR0B1; ZNF43; ZEB1; FLI1; NR4A1; NCOA2; SPDEF; EN1; REL; ZNF133; YEATS2; SPIB; ZNF273; KLF11; NEUROD1; HOXB2; PITX2; ZNF394; IRF1; MED15; ETV5; MEF2C; BBX; CUX1; TAF6; ZNF267; SSBP2; NR1H4; JUN; ISL1; KAT6B; MAF; TFDP2; E2F5; GATA4; ACTL6A; ZNF587; TOX; INSR; ZNF721; CSDE1; TAF11; TCF7L1; TFEB; IRF7; PAWR; ANKRD1; GATA2; NFE2L3; FOXN3; SSX1; INSM1; CCNE1; FOXF1; CRYM; MITF; MED17; NR4A2; ZNF544; NR1D2; ZNF430; BACH2; LITAF; ID3; STAT4; RORA; NKX2-1; HDAC6; TBX3; BRD4; CREM; ZFHX4; MEOX2; FOXA2; SOX11; HOXB6; BTG1; TCF7; BHLHE41; EGR2; OSR2; ZEB2; LOXL2; CREB1; POU2AF1; ASCL1; TBX2; ZNF586; THAP11; DACH1; IKZF1
Down-regulation 192 CCNA2; CRK; PUF60; FOSL1; MYC; TLE1; NUP62; ATF6; FHL2; TCERG1; RBM14; NRIP1; HDAC2; SMARCE1; CENPF; SNW1; AATF; ATF1; UBE2I; YBX3; BAZ1A; HOXA5; RBBP4; HOXA10; EZH2; SSRP1; TP53; CDK7; ADRB2; BRD3; MED6; CNOT1; USP22; HNRNPD; SFPQ; SUV39H1; RAN; GTF2A2; HDAC1; HMGB1; PTTG1; XBP1; ITGB3BP; BCLAF1; XRCC6; RBBP7; SMARCA5; CRY1; NCOA6; DR1; ZNF146; TBP; ECD; MYBL2; TBL1X; NACA; ZNF410; NPM1; NCOR1; SMAD2; HMGB2; CTR9; WHSC1; ZBTB24; RNF138; PATZ1; ILF2; FOXM1; CARM1; MAX; PURA; RUVBL2; NCOA4; RCOR1; PRKDC; KAT5; TAF9; SAP30; HOXB7; RNF14; COPS5; ZNF672; CEBPG; TRIM28; RNF6; NEDD8; ING2; BRD8; DNAJC2; JARID2; UBP1; ELF1; MED4; GABPA; YAF2; DEK; RREB1; CEBPZ; CCDC59; SMARCC1; ORC2; IKBKAP; NONO; TSC22D1; PCGF2; WWTR1; MED1; HDGF; HOXC6; CBFB; PQBP1; ABL1; NFIB; EED; YWHAB; EDF1; PSPC1; SOX9; BAZ1B; PA2G4; MTDH; ELK3; NELFB; PPRC1; YBX1; TSC22D2; BHLHE40; NFYA; CHD7; BMI1; SP3; UBE2L3; HOXA7; VEZF1; NFYB; NFKB1; TRIP6; MBD2; NR2F2; BRCA1; TBL1XR1; DNMT3B; KLF10; ATF4; HSBP1; PHF2; APEX1; TCF12; PMF1; PHF20; FOXD1; HOXC10; BLM; CDK8; NKX3-1; FOSL2; TRIM29; RNF111; RNF4; KDM5D; ELF3; HMGB3; ENO1; CBX3; HIPK3; GTF2IRD1; AFF1; ETS2; ERBB2; BASP1; SIX1; SMARCA2; SMARCD2; NR2F6; PPARGC1A; SIAH2; TFDP1; ZBTB18; SMAD3; TGIF1; TRIM16; MED24; POU4F1; ZBTB38; HLTF; SUB1; RBBP8; SCAND1; IFI16; KLF5; STAT5B; NR3C1