Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17080 Withaferin-a GSE70138 MCF10A Human 3h 3.33uM EID0009
Types Number Response transcription factors
Up-regulation 81 STAT5B; GABPB1; KDM5A; XBP1; DDIT3; ATF3; ZNF473; SERTAD2; OSR2; PIR; PIAS2; SAP30; EGR1; EYA2; SFMBT1; JUNB; NR1D2; ATF4; AFF4; HOXC10; RNF141; TBPL1; PITX1; ADNP2; TBP; ZNF267; STAT5A; RUNX3; SIX1; TCF20; UBE2B; MSX1; MAX; ID2; ZMYM2; RLF; EZH2; ELF3; BTG1; TAF9B; ZNF394; FOXC1; EGR4; RNF14; FOXO4; SMAD5; SMARCE1; HES1; CEBPA; E2F2; KDM2A; ARID4B; RCOR1; ZBTB18; LPIN2; FOXF2; PHF20; RBPMS; BCL11B; MYT1L; EGR3; HOXC6; NKX2-2; AFF1; JUN; HTATIP2; HLTF; BCLAF1; IRX5; MED1; TOB1; ELF1; KDM5D; TRIP6; TBL1X; FLNA; JARID2; CALR; FOSB; MEOX2; KLF2
Down-regulation 86 MYC; HOXA5; HOXA10; NFKBIA; ADRB2; ZNF512B; NFE2L3; WT1; TFAP2A; CTBP1; MLXIP; ZNF593; HOXB5; ZNF160; NR1I2; FOXN3; GTF3A; HLX; BCL11A; CHD9; NR0B2; ZBTB16; ZNF611; SUPT4H1; VDR; FUBP1; HMGA2; HMBOX1; ZNF652; ZHX2; ARL2BP; CREBL2; ESR1; PBX3; ZNF721; BNC2; CUX1; ZNF589; EMX2; ZNF573; CBFA2T3; APEX1; ZFP36L2; HOXB6; E2F5; LMCD1; NR2F1; TEAD4; ZNF281; ETS2; FOXA2; IFI16; NKX2-1; EP300; PKNOX2; TRPS1; ZNF239; JUP; ZNF91; SOX17; BACH2; ZEB1; ZBTB20; IRF9; TOX3; ARNT2; GLI2; TWIST1; SCAND1; ID4; TRIM29; NFATC4; ARID5B; MYBL1; TCF4; MYRF; ERBB4; SOX2; NANOG; KLF11; SOX11; TCF21; CUX2; VPS72; TBX2; MEF2C