Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID17052 Linsitinib GSE70138 MCF10A Human 3h 0.37uM EID0009
Types Number Response transcription factors
Up-regulation 25 KDM5A; GATA3; TSC22D3; BRCA1; IKZF5; SOX4; HIVEP1; MYB; PIAS2; RBBP4; MYT1L; BASP1; ID3; KLF2; ID2; TSC22D1; BTG1; ZIC1; ZBTB38; ATF3; ERBB2; TLE1; FOSB; ID1; KDM5D
Down-regulation 80 NR0B2; ZNF512B; AEBP1; FOXL2; HEY2; ESR1; SPIB; ZNF573; JUN; ZNF544; KLF11; GATA1; ARL2BP; MECP2; CDIP1; KLF6; DLX5; BRD4; JUND; HIC2; WT1; KLF10; MDM4; TCEA2; NFIC; FOXA2; PITX1; HDAC9; ZSCAN18; ZNF589; NFATC4; ZEB2; TGFB1; EMX2; LHX3; KLF4; SOX2; ZFP36L1; CERS4; CREB5; CBFA2T3; ZNF467; KLF13; NR5A2; TCF21; NFE2L3; SOX17; ETV5; MYRF; ZNF75D; ZNF117; SALL2; NR1H2; MNDA; TFAP2C; HOXB2; NFE2; MEIS1; KAT2B; ZNF331; PEG3; HOXD1; NR1H4; GLI2; MYCL; ZNF43; ZNF423; GATA6; HHEX; POU2AF1; ARNT2; PBX3; NFATC3; NANOG; BHLHE41; MEIS2; LEF1; VPS72; TCF4; E2F2