Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16660 Mitoxantrone GSE70138 MCF10A Human 3h 0.12uM EID0007
Types Number Response transcription factors
Up-regulation 699 NR3C1; LIMD1; ZNF586; PIAS2; PEX2; BRPF1; SMARCA2; E2F2; STAT2; NFX1; CBX7; REPIN1; HCFC1; RELB; CTNNB1; TFE3; TCEA1; PPARGC1A; ZNF580; MED12; EBF2; SHOX; OLIG2; ZHX3; EP300; ZNF816; CXXC1; HIVEP3; TUB; ASH1L; SUV39H1; PLAGL2; TBL1XR1; SP140; ZNF446; TAF4B; HNF4A; ADNP; KAT2B; KLF12; ONECUT2; HMG20A; BCL10; RERE; AFF2; KLF13; ZSCAN32; NCOA2; CREB3L1; IRF4; FOXD2; FHL5; NKX2-5; CDX1; ZNF175; PML; POU2F1; RARB; HOXA1; HSF1; IL16; MAFG; PAX1; NCOA6; HNF1B; HOXC4; BRF2; WWP1; EZH1; CNOT2; FOXL2; RBL1; NFIC; TRIM32; LHX2; ZNF587; TGS1; POU3F3; KLF15; DDX17; ATF7; KMT2D; NR3C2; SSX7; EMX2; ARID3A; ZNF532; HMX1; ZNF282; ZNF304; HNF1A; ATOH1; ARID4A; TFDP3; MSL3; SSX1; MBD1; ZNF343; BARX2; CIC; SIX3; ZNF197; LMCD1; MYT1; NKRF; ZNF507; HEYL; HDAC11; IKZF2; IRF2; ZIM2; ASCL3; ZNF324; FOXJ1; ZNF384; OSR2; TFCP2L1; DMRT1; NEUROD4; HIPK2; KDM5A; CREB5; JUNB; TAF6L; EN2; AIRE; NR1I3; ZNF221; HOXA11; TSHZ2; ZNF771; TFAP4; ZNF721; ZNF215; EHMT1; TSC22D4; TFAP2B; ZNF611; CDX2; RBBP4; CBX6; ZNF536; PROP1; ZNF528; ATF6B; POU6F1; GBX1; HOXA4; TRAF6; CHAF1B; TBX21; ZFY; ZNF516; ZNF770; GLI1; RFX2; LHX3; SPIB; POU4F1; VENTX; ZNF248; FOXC1; ZNF552; CLOCK; KAT7; FOXP3; PRDM5; SOX21; ZNF132; FEV; WHSC1L1; TADA3; CIITA; ARID5A; SMAD9; BPTF; ZNF408; ZNF654; DLX6; FOXI1; ZNF701; LHX6; ARHGAP35; ZNF835; TFEC; CHD2; ZFHX2; NEUROD1; TAF7L; ZKSCAN7; ELF3; HOXC11; FOXD3; TOX; TLX1; HOXC5; MED25; BLM; TADA2A; MAML3; PRDM12; SCAI; SIM1; HEY2; ALX4; PRDM14; BCLAF1; ZSCAN18; ZNF506; MBD2; SOX3; ZNF287; ING1; IRF1; HNF4G; ZNF671; PAX2; WNT4; SMAD2; ARID3B; FOXH1; ELK1; POU3F4; ING4; ESR2; ONECUT1; NEUROD2; PAX3; MECP2; ERF; ZNF493; DOT1L; FOXA2; EYA2; ZNF695; ZFP30; MAP3K10; KDM5D; ZNF484; ZNF492; MED31; ZNF235; RORB; ZBTB38; PRDM1; ZNF208; NKX2-2; NR5A1; POU6F2; ZNF337; NR5A2; ZNF223; SMAD7; THRB; DAXX; MED23; RARA; RBPJL; HOXD3; ZNF688; ESRRB; PHF8; HOXD13; PRRX1; TULP2; PRDM4; NRF1; CDX4; IKZF3; RORC; TRIM33; GCM1; HES2; RAX; HOXC8; RUNX2; ZNF550; ZNF34; EPAS1; ASCL1; TSG101; MTA2; RFX3; ZNF160; ZSCAN5A; MLXIPL; ZNF174; ZNF629; ZNF419; ZNF324B; ZNF217; ZNF510; PHOX2A; TERF1; HABP4; CNOT3; TCF20; PRDM13; ETV5; NFRKB; NFIX; DLX5; ETV6; SMAD5; ZBTB44; NFKBIB; ZNF227; MNAT1; DCC; PROX1; POU2AF1; PRDM16; RARG; ZIC4; ZNF142; FOXJ2; SOX5; BCL3; IRF5; NEUROG1; BHLHE41; POU3F1; ZNF75D; PRMT2; ZNF710; TBX4; ETV7; OVOL1; HOXD12; ZNF226; EVX1; FOXN1; ZNF268; HLF; MZF1; PHOX2B; RNF111; RFX1; CAMTA2; SP4; CBX2; ZNF814; ZNF667; CHD4; IKZF4; TBL1Y; ZNF471; ZEB2; ZNF415; KMT2A; MAPK8IP1; CBX5; ZNF35; USP16; KLF3; SNAPC4; POU2F2; CRTC1; TULP4; NR1I2; POLR3C; NKX2-8; ZNF442; ZKSCAN8; ETV3; ZNF473; APBB1; EN1; PAX7; AFF3; ZNF391; MLLT1; E2F1; ZNF672; CCNT1; SAFB; ZKSCAN3; SSX3; FOXE3; MED14; ZNF574; ZNF14; SOX17; ZNF222; HOXA2; HLTF; ZNF768; PAX4; SOX1; EYA1; CBL; TEF; BAZ2A; PRDM8; EED; JAK2; ZSCAN16; SSBP3; ZNF665; VGLL1; PKNOX1; BATF; GFI1; ZNF3; SOX2; ZNF589; FOXC2; PPARA; ZNF358; ZNF124; HOXB1; ELF4; FOXG1; ZNF778; ZFHX3; ZNF76; ZNF264; CTR9; POU2F3; NHLH1; NKX6-1; NR2F1; RNF14; EYA3; SUPT6H; ZSCAN2; TAF1C; ZNF749; ZNF23; NEUROG3; CEBPD; ALX1; TRRAP; ZNF292; KDM4A; PIAS3; TRPS1; ZNF467; BRD2; SOX13; ZNF236; POU4F3; TFEB; ZFP64; RUNX3; ASCL2; PRDM9; CREBZF; RSF1; HOXC13; GATA1; ZKSCAN4; HIVEP2; ASXL1; PKNOX2; TRIM22; ZNF112; CAPN15; MYBBP1A; LZTS1; SCRT1; ZBTB6; RBPMS; TP63; ZNF41; ZNF225; OVOL2; EMX1; TFCP2; TP73; LBX1; ZNF154; LMO1; NR1D2; ZNF512B; GATA4; GRIP1; DYRK1B; SOX10; SALL1; TBR1; RFX7; MDM4; VGLL4; HDAC4; HOXC10; PRDM10; SIX6; BATF3; SOX12; ZNF80; ZNF345; TBX3; NFAT5; CARF; NR6A1; TBX1; ZNF286A; NCOA1; HIC1; MED1; TAF1; FUBP1; TULP1; RBBP7; TGFB1I1; PAX8; MBD4; ZBTB20; KDM2A; MSC; HOXB8; ZNF81; MEF2C; TCF21; NR4A2; ZNF135; CSDC2; TCF7; CHD1; TRIM25; MAF; ZNF253; NR0B1; DLX4; HOXA3; VDR; ACTL6B; LYL1; TDP2; CREM; WWTR1; ZBTB39; NFATC1; ZNF783; SCMH1; BNC1; MECOM; ZNF211; ADNP2; SATB2; PPARD; NFKB1; MYOD1; KAT6A; ZNF444; ZNF606; UBP1; FOXN3; NR1H2; ZNF573; ZNF24; GATA2; MEIS1; ZNF189; ZNF180; SNAI1; PITX3; SOX18; HOXA6; ZNF500; TCFL5; AATF; ZFP37; CSDE1; ID4; FOXO4; TBX19; NCOR2; ZNF134; ZBTB25; CREB3L2; ZBTB43; YWHAB; SSBP2; MNDA; TLX3; SRY; ZNF224; BRWD1; HMBOX1; PIR; ZNF45; ZSCAN9; NRL; NR1H4; IRF9; MXD3; SMAD4; ZEB1; PLAG1; CEBPZ; E2F8; NANOG; ZNF281; WT1; KLF1; RBM14; ZNF136; NFIB; THRA; USF2; ANKRD1; ZNF331; CIR1; HEY1; CEBPA; MLXIP; SMAD6; IFNB1; LITAF; IRF6; ZNF8; ARID5B; PIAS1; INSM1; NLK; ZNF329; EGR2; PAX5; ESRRG; AR; E2F5; PPARG; DNAJC1; TBP; IRX5; SOX15; PLAGL1; WDR77; FOXF1; ZNF267; EGR3; NPAS2; FOXO1; HMGA1; ZNF266; SFPQ; HESX1; POU3F2; TLE2; BASP1; BMI1; PRDM2; USP22; AFF1; ZNF93; FLI1; PARP1; HOXD11; NPAT; ZNF274; TCF4; CARM1; ZFP36L2; KLF9; HOXA10; LEF1; GATA6; CUX1; SKI; MEIS2; ARNT; MYCL; NR4A1; ZBTB16; ADRB2; TFAP2C; TRIM24; MAGED1; ZNF423; PAX6; CHD7; ZNF148; TFDP2; ERBB2; LPIN2; MYT1L; PBX1; DACH1; HES1; PGR; BACH1; ERBB4; MTA1; PRKDC; PEG3; NR2F2; DBP; IKZF1; VPS72; STAT1; TOX3; ING3; SCAND1; SNAI2; ZNF430; HOXD1; ZNF91
Down-regulation 167 RCOR1; PSMD9; CDK7; MYCBP; YAP1; PMS1; TEAD4; NFKBIA; PUF60; RHOA; CUX2; PTTG1; CITED2; TAF9; C1D; DRAP1; MED17; SREBF1; IRF3; CRY1; ETS1; MED21; SUMO1; MNT; RAN; TSC22D3; MMS19; ZBTB1; CNOT6; ZNF692; GABPB1; ID1; MYC; CEBPB; HTATIP2; ZNF410; TCERG1; HHEX; DLX2; PCGF1; PPRC1; ENO1; CBFB; BTF3; BRD8; ILF2; ZBTB11; CARHSP1; BANP; CTCF; THAP4; YBX1; ERCC3; WHSC1; ZNF593; NEDD8; CBX3; RNF138; UBE2I; ATF2; TRIP6; GTF2I; UBE2L3; BRD7; EDF1; BRIP1; ZKSCAN5; NACA; BIRC2; PMF1; JUND; FOSL1; PPP1R13L; PCGF3; NFE2; RFXANK; NFYA; PAWR; TCF25; KLF11; TCEB2; HMG20B; SRCAP; HOXB2; CNBP; CREB1; CD3D; TCEA2; HMGN3; HIRA; CCNE1; RAD21; MED27; ATF3; TOX4; PSPC1; PSMC3; ZFP36L1; PITX1; ITGB3BP; ZNF165; NELFB; CDK8; RUNX1; COPS2; CENPF; HOXB6; HINFP; MED6; CCNC; ACTL6A; PBX3; TAF1D; ZIC1; SMARCA4; BAZ1A; ZFX; PEX14; IRF7; SHOX2; ATF1; PHF20; RLF; YBX3; RRN3; TLE1; TRIB3; TOB1; SP110; MYCN; FOXD1; APEX1; NPM1; LIN28A; BACH2; BCL6; TULP3; TGFB1; ZSCAN31; MEF2A; DEAF1; SOX11; ZNF232; CTBP2; CREG1; PA2G4; RBBP8; ARID4B; ZNF117; CRK; RUVBL1; CALR; TXNIP; CRYM; GTF2A2; ID2; WWC1; ARNTL2; ZBED2; ESR1; MITF; BCL11B; MSX1; NRIP1; ZNF43; NR2F6; MAFB