Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16658 Mitoxantrone GSE70138 MCF10A Human 3h 1.11uM EID0007
Types Number Response transcription factors
Up-regulation 255 EBF2; RELB; POU4F1; HMGXB3; BTG1; ETV1; PPARGC1A; SREBF2; ZNF384; ZBTB38; HCFC1; EGR1; EP400; FHL5; ID3; ZBTB39; PITX2; HOXB9; TUB; PRDM4; MEOX2; LEF1; FOXP3; GLI1; HOXC13; HMGB3; ERBB2; CDX2; PLAGL2; CHAF1B; HAND1; JUNB; ETS2; KMT2A; POLR2A; MEF2C; CBX5; NR3C2; DDX5; SMARCD1; TCF20; ZNF770; CTR9; TBX10; PML; PRRX1; NKX2-8; HABP4; ZBTB40; SSBP2; KLF6; RBBP7; NFRKB; NFKBIA; BATF3; ARHGAP35; VGLL4; MAZ; NKX2-1; KDM5A; POU2AF1; E2F5; DLX2; ZNF672; FOXC1; KLF10; KAT7; ZNF215; HOXB13; ZNF446; AGO2; HIVEP3; ZNF226; DLX6; PRDM1; NFIL3; MYOG; HNF1A; RBBP4; BPTF; MAF; TLX1; POU6F1; BRF2; CNOT6; AIRE; NR4A1; ZNF528; CREBZF; EGR2; DACH1; PMF1; MNAT1; NFAT5; PIAS2; ZNF536; CDX1; ZNF266; ASH2L; PROX1; MLXIPL; SP1; AFF4; FOS; CIC; NFIX; SIM1; EYA3; ZFHX3; ZNF140; VDR; ASH1L; EPAS1; MYF6; KAT6A; HOXA11; ZNF529; SIRT2; FOXJ2; GATA2; HOXA10; HOXA3; POU4F2; ZNF286A; MBD1; PHOX2B; AFF2; HIPK2; KLF15; E2F3; PROP1; KDM5C; NR1H2; SERTAD2; ARID1A; ZFX; LMCD1; SFPQ; ESRRG; POU2F1; CDIP1; SPEN; RNF14; PPARG; CLOCK; EYA1; HOXC11; ZHX3; ZNF816; ZNF835; CHD4; FOXJ1; TBX1; NCOA6; ARID4A; ZIM2; ARID3B; TFEC; ACTL6B; HOXC4; POU2F2; TAL1; PRDM5; NEUROD2; ZBTB43; LHX2; SRY; SMAD5; ATF3; MYT1; FLI1; SSX3; SRF; KDM5B; HLX; UIMC1; ZNF302; ISL1; HNF1B; HIVEP2; BCLAF1; IRF4; TBX2; MAFB; SKI; RNF141; NEUROG1; ZNF235; THRA; TP63; NR4A2; TCF7; SOHLH2; RFX2; PCGF2; TAF7; TCF4; FOXN3; KDM5D; AHR; GFI1; TFAM; RBL2; SMARCB1; UBE2I; ARID5B; MNDA; ELF3; CREBL2; BRD2; ARL2BP; LPIN2; HSBP1; SOX11; ZNF629; BASP1; ATF7IP; ID1; MAGED1; NR1D2; SF1; HES1; FOXM1; TBL1X; ATF5; ZEB2; SIAH2; HMGB1; USF2; PSIP1; TERF2; FOSB; ZNF606; RFX5; CASZ1; SATB2; LHX6; KLF4; NKX3-1; MTA1; HOXC10; MKL2; JAK2; ZNF274; DNAJC1; FOXF1; CREG1; IRF6; SSBP3; KLF5; RBFOX2; HOXC6; ID4; HOXD1; TRIB3
Down-regulation 149 PMS1; TFAP2C; RARA; ZNF654; NR3C1; WWTR1; MYC; SP140L; BAZ2B; KAT2A; SP100; CHD9; LDB1; PLAGL1; GTF3A; MYRF; IRF9; BRD7; BRPF1; ZNF410; SIRT7; YAP1; ZNF589; ZNF692; ELF5; EHMT2; PBX2; SUPT7L; PREB; SP3; SIN3B; TSC22D3; ZNF217; SAFB; MYBL1; PIAS1; CCNE1; TEAD3; SLC2A4RG; TGFB1; RHOA; NEUROD1; ZMYND8; SAFB2; ZZZ3; ELF4; ZNF202; ETV5; SOX13; BTAF1; IRF1; MXI1; PQBP1; EYA2; ZNF304; DEK; RB1; PURA; TGFB1I1; MTF2; CITED2; ELK3; RORA; HBP1; TRIP4; KAT6B; ZNF117; CEBPD; PAXBP1; EHF; TRPS1; HMGA2; CENPF; RYBP; ZNF500; ZNF131; CEBPB; DPF2; TRIM22; CBFB; ZNF273; ABL1; TGIF1; ZMIZ1; HDAC1; HTATIP2; PSPC1; HMBOX1; RUNX3; CREB3L2; ZNF268; SP110; SOX4; HIRA; TAF1D; RNF6; MNT; TCF21; MEIS2; TLE1; GCFC2; NRIP1; ZNF586; NR2F6; TCEA2; OVOL2; ADRB2; ZNF165; PAX6; CCNC; KDM4C; ZNF133; LOXL2; TCF7L2; ZNF91; ATF6; NCOA3; STAT5B; TLE4; JARID2; ZNF12; ESR1; SUMO1; MEIS1; AES; ZNF467; ZNF14; TRIP6; FOXJ3; WWC1; MBD2; ZBTB18; NFATC4; GATA3; HLF; ZNF93; HOXA5; ZEB1; APEX1; WT1; IRF8; IFI16; ZFP36L1; DBP; MYB; THAP11; STAT1; CCNA2; SNAI2