Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16657 Mitoxantrone GSE70138 MCF10A Human 3h 3.33uM EID0007
Types Number Response transcription factors
Up-regulation 565 ING1; HMGXB3; FOXL2; TCFL5; MYNN; ESR2; KAT7; ZSCAN5A; ZNF444; BTG1; CREM; ACTL6A; WWTR1; PAWR; PHF1; HOXC4; ARID4A; LMCD1; NKRF; NFAT5; SREBF2; ZNF580; TOB1; CLOCK; MAK; NR4A2; ZFHX2; HOXA4; MNX1; PLAGL1; CEBPZ; CEBPD; ZNF140; ING2; SETD3; ZSCAN12; NR3C2; HIVEP2; SMARCA2; KLF12; UBE3A; BRCA2; ZNF639; HEY1; NFRKB; ZNF331; LHX6; CDYL; MYF6; FOXJ2; GATA6; LZTR1; IRF4; BCL6; RBL1; HNF4A; KLF10; WNT4; DAXX; PIAS2; PEX2; SOX30; SPIB; ZHX2; THAP7; ZNF473; BPTF; ZNF160; ZNF721; E2F8; TBPL1; MYCL; ESRRG; NANOG; SSBP2; IRF8; MTF1; ZNF467; BNC2; SIX3; ZNF165; EN2; NR1H2; ZMIZ1; ZNF446; REPIN1; KAT2A; FOXH1; TCF7; OLIG2; PNRC1; PAX8; ZHX3; GLI1; ZBTB48; ZNF536; TBX4; ZBTB1; MKL1; ELF2; REL; SNAI1; ZNF516; SOX10; BCL11A; EMX2; ZNF419; POU2F3; CCDC59; HDAC4; PATZ1; SATB2; MYF5; FOXG1; WWC1; PPARGC1A; HLTF; MZF1; YBX2; PRDM13; SHOX; ZNF124; ZNF507; BCL3; SSX7; RBBP5; PRMT2; POU5F1B; ZNF611; ID4; SMARCA1; ELK4; SCAI; ZNF235; POU4F1; PPARA; IKZF2; HMBOX1; BRD2; IKZF4; TBX6; FOXC1; ZNF384; CAMTA1; SIX6; CERS4; NR0B1; SKIL; ETV3; CIC; TBL1XR1; TULP2; FOXL1; ZNF324; JAK2; HOXC6; HIVEP3; TFCP2L1; TBL1X; NEUROD6; ZNF208; MYOG; PEG3; ZNF345; PKNOX2; SSX3; HNF4G; CSDE1; RXRA; ZNF688; TSHZ2; ZXDC; ZBTB32; TGFB1I1; ZNF212; NFATC1; BRDT; IRX5; AFF2; KAT6B; TRIM27; RARB; SAFB2; TFEB; ZNF551; BATF; ZNF354A; NCOR2; ZNF696; ZBTB43; CSDC2; ZFX; ZNF362; ARID5A; NHLH1; CBX6; NFKB2; POU3F1; NR5A2; PBX1; ZFP2; CREB3L1; THAP10; HDAC6; ERBB4; ZNF23; SP140; ZNF34; SIM1; ZIM2; MLLT10; TAF11; FOXD2; FHL5; ZNF556; ZNF44; HOXC11; VAX2; EP300; CCNT1; SIN3B; GCM1; NR5A1; NKX2-8; TFDP3; PSPC1; TAF4B; NR1H4; ELF5; HIPK1; HLF; ZBTB40; ZSCAN31; ZIC4; SMAD6; NSD1; NFKB1; HOXA1; KLF9; HMGA1; PURA; NR1D2; ZFP30; UIMC1; ZNF302; LDB1; ZNF492; EP400; CIITA; TAF4; ZBTB7A; MTA2; THAP3; HEY2; USF2; DNMT3B; APBB1; ARID1A; MYOD1; SIAH2; NRF1; BRIP1; ZIC1; RBL2; NCOA1; BANP; ZNF587; ZNF263; NR1I3; POLR2A; FOXJ1; CHD3; CRYM; NR0B2; TULP1; MAFK; TCF25; NR1I2; MKL2; ZBTB20; PRDM9; ZNF493; TUB; ZKSCAN3; MITF; ZNF778; PDLIM1; GATAD2A; DLX4; ZMIZ2; CBX7; FOXO4; RBBP8; KLF11; ZNF410; YEATS4; RCOR1; NAB2; TAF7L; ONECUT1; ELK1; ZNF586; WDHD1; TXNIP; GRHL2; MAF; E2F2; TGIF2; RXRB; ZKSCAN4; REST; TBX19; CASZ1; ZNF665; ATOH1; ZNF343; ZBTB44; ZNF443; RORA; ZNF197; ZNF324B; ETV5; NR2F2; C1D; DMRT1; TBX2; HOXD3; MAML3; OSR2; EBF2; CBX4; BIRC2; EZH2; AHR; CRX; FOXN3; TRIM32; ATF1; TFAP2C; ZNF84; FOS; SNIP1; MAPK8IP1; SATB1; ZBTB11; ZNF432; ZNF287; ZNF211; SOX9; ZSCAN18; ZBTB38; HOXB13; AIRE; CEBPE; HOXD12; CRY1; FOXE3; ZNF391; NR4A1; ZNF248; NPAS2; WT1; MSX1; ARID5B; EGR3; CREG1; NPAS1; ZSCAN16; ZNF266; ERG; ZNF224; IRF7; ZMYND11; HOXD9; THRB; SCMH1; ZNF669; EN1; KMT2B; SFMBT1; NEUROD4; RNF14; FOXI1; ING3; ETV2; ARNT; POU2F1; RFX5; GCFC2; PKNOX1; HOXC10; EMX1; MEOX1; KLF6; ZNF574; DACH1; ZNF32; HIF3A; NKX3-2; TBX3; ZNF10; KMT5A; FOXD1; NFIB; POU2F2; KLF5; URI1; TAF1; CHD2; FLI1; SUPT4H1; SPEN; ZNF304; PAX2; CEBPA; POU3F2; ZNF529; ZNF239; ALX3; CDK2; CCNE1; HINFP; ZNF107; BATF3; TEAD3; MAFF; SOX3; ZNF512B; ZNF440; NFE2L3; CHD4; TADA3; PHOX2B; HOXC5; TBX21; ZBTB25; VENTX; TCF21; SRCAP; SSBP3; GBX1; FOXJ3; ETV6; ZNF134; SALL1; ZNF135; TAF1C; MYRF; TCF15; ZNF223; HES1; NFKBIB; MBD1; JUNB; BLM; TSC22D2; DBP; VEZF1; TAF7; ZNF329; SMAD4; NEUROD2; PAX5; MXI1; ZNF16; ZNF667; SP110; ZNF500; ALX1; BHLHE40; RUNX3; SALL2; ZNF571; PCGF1; ZNF93; NLK; ZNF24; TDP2; LHX2; HMG20B; KDM4A; OVOL1; ATF7IP; ZNF544; JARID2; HOXA5; YAP1; ZNF267; ATF4; ZNF226; TLE2; NR2C1; MNDA; ZNF131; MYT1L; SIM2; ZBTB14; DLX5; ZNF652; POU4F2; MED1; ZNF22; ADNP2; FOSL2; ZNF274; COPS2; ZNF14; SMAD2; ZNF510; ZNF394; ZNF136; LIN28A; TLE1; PLAG1; CDK8; ZNF83; CBFA2T3; KLF1; MED6; ZNF85; LITAF; IRF5; KDM4C; NCOA3; ZNF184; TOPORS; TOX; ZNF426; LEF1; MEF2A; ZNF606; ZFHX4; STAT5A; INSM1; MTF2; MECOM; GLI2; ZNF175; ID2; DEK; BACH2; AFF1; ZNF415; ZNF629; SMAD3; CHD9; ZNF217; CARHSP1; ZFP36L1; ZNF200; MAFB; TOX3; KDM5A; NKX3-1; ZNF430; NR4A3; FOXE1; ZNF423; ZNF264; FOXF1; MYB; BHLHE41; BCL11B; HOXD1; ZNF91
Down-regulation 202 GTF2IRD1; HDAC2; TRIP6; CCNH; TSG101; HMGA2; TFDP1; TCEA1; THAP4; EED; TRRAP; PCBD1; TERF1; PSMC3; NFE2L1; ELF3; UBE2I; SMARCE1; BAZ1B; ID1; MYBL2; CNOT6; ELK3; SMARCA5; THRAP3; MEN1; RB1; VGLL4; NFKBIA; ZFP36L2; PTRF; BTF3; SOX4; HOXB2; CCNC; GABPB1; CCNA2; CITED2; MED17; YBX3; MMS19; TGFB1; NRIP1; CTCF; NR2F1; CDK7; SMAD7; NCOR1; CBFB; BRD3; NONO; EDF1; RBM39; YBX1; ENY2; PITX1; USP22; ZNF281; DRAP1; RARA; CBX3; AATF; ARNT2; VPS72; CDC5L; HIF1A; PSMD9; RHOA; MED4; ETS2; CREB3; MED16; PPP1R13L; GTF2A2; SHOX2; DPF2; TCF3; NOC2L; ECD; ETV4; MYCBP; HNRNPD; GMNN; PBX3; ZBED2; NFX1; TFAM; ZNF195; RBM14; FOSL1; CDK9; ILF2; PQBP1; ITGB3BP; HMGB1; SMARCA4; RUVBL1; FUBP1; RUNX1; ST18; HMGN3; EGR4; MAGED1; TAF9B; HAND1; IKBKAP; CTR9; BRD7; PRDM1; SMARCC1; PIR; RFXANK; CDIP1; PMF1; SUZ12; SOX13; NCOA2; HOXB6; TGS1; ZBED1; PREB; DMTF1; ASH2L; USP21; FHL2; CIZ1; MTDH; BBX; PRKDC; ZNF576; NKX2-2; KDM5D; CUX2; SOX2; SOHLH2; RBPMS; PLAGL2; FOXA1; ESRRA; SREBF1; HOXD11; RBPJ; TFAP2A; YWHAB; NRBF2; TULP4; IFI16; MED12; TFEC; BCOR; TULP3; DDX17; ESR1; COPS5; TWIST1; TRIB3; ETV1; PA2G4; TRIM22; HOXD10; HMGB3; RNF6; HIC2; MTA1; RYBP; ZNF532; KLF7; ZNF117; ATF3; FOXO3; HDAC1; LPIN2; MYCN; SIX1; GTF3A; DDX5; PUF60; C1QBP; MEIS1; ATF6; TRAK1; HBP1; EHF; ISL1; JUP; CBFA2T2; RAN; ZNF12; ARID4B; PSIP1; SCAND1; RBFOX2; ZFPM2; LOXL2; MBD2; AEBP1; PARP1; EGR2; HOXA10; ZEB1; HOXB5; NR2F6