Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16625 Alpelisib GSE70138 MCF10A Human 3h 0.04uM EID0007
Types Number Response transcription factors
Up-regulation 17 VGLL4; SOX2; SMAD5; TSC22D1; MAGED1; FLNA; TRIP6; ZMYND8; KLF10; ENO1; ZBTB38; VEZF1; HOXA5; HMGB3; BASP1; ZNF652; TRIB3
Down-regulation 56 PPP1R13L; WWP1; KLF4; CDK9; TFAP2C; MYCL; PITX1; GATA6; ANKRD1; ZNF117; KLF11; ZNF239; LEF1; FOS; RRN3; CREBL2; BRWD1; IL16; ZNF107; E2F2; ZSCAN18; PBX3; HMGB2; ZNF350; BHLHE41; SAP18; GRHL2; TSC22D2; SMAD6; SMAD7; LMCD1; PRDM2; JAK2; ARID5B; HTATIP2; ZBTB16; ESR1; MAFB; AEBP1; ID2; ERBB4; TBX3; CD3D; ZEB2; MITF; GATA3; SALL1; ZNF443; ZNF91; HOXC6; TFDP2; ZNF274; DACH1; NCOA1; ZNF43; ID4