Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16621 Alpelisib GSE70138 MCF10A Human 3h 3.33uM EID0007
Types Number Response transcription factors
Up-regulation 42 TSC22D3; KDM5B; CNOT2; KAT6B; ID2; SATB1; FOSL2; MXD4; WWTR1; CTR9; MLXIP; TSC22D1; ZMYND8; RFX5; MITF; LITAF; KLF5; ID3; SOX4; CUX1; TP63; JUP; PDLIM1; TRIM24; NR4A2; PSIP1; ERBB2; CREG1; PBX3; HMGN3; MEIS2; SOX11; ID1; TWIST1; HOXA5; TBX3; TRIM29; TRIB3; ZNF652; MXI1; NR2F6; BASP1
Down-regulation 39 JUN; SOX9; ERF; TAF5L; NKX3-1; RUNX1; ZNF432; HEY1; SIX1; MED1; ZNF177; LMCD1; SPEN; EGR2; HIVEP2; EGR3; JUNB; ARID4B; SSX1; ZBTB43; ZNF614; NFAT5; NFKBIA; KLF9; ADNP2; RSF1; NPAS2; BRD2; CEBPA; DMTF1; SATB2; MYRF; NRIP1; BHLHE41; ZEB2; MNDA; ZSCAN18; IKZF1; ID4