Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16575 Pf-477736 GSE70138 MCF10A Human 3h 1.11uM EID0007
Types Number Response transcription factors
Up-regulation 571 NR3C1; ZBTB40; PBX2; GATA6; VGLL4; RNF111; ESR2; RXRB; MYNN; NAB2; MYOG; MAML1; EED; WWP1; ZMYM2; TAF11; DAXX; ZNF266; RCOR3; ZNF304; SMAD6; AFF1; ADNP; ZNF175; GLI1; ZNF292; PRMT2; ZBTB7B; ZKSCAN4; NR4A2; RERE; HOXB13; ZSCAN16; TGIF1; BAZ2B; NKX2-8; TRIM33; BRPF1; ZNF76; TBX10; LMO1; FOXH1; ZNF468; MED23; TBP; CRTC1; HOXC8; BRD3; FOXO4; FOXN3; GATA2; HINFP; MED13; RNF2; IRF8; MEF2A; ZNF768; CITED2; CIC; NFRKB; KAT2B; KAT7; ALX1; ATF3; UBP1; PHF1; NAB1; PNRC1; RING1; ARID4A; TSHZ2; BARX2; SETD3; TRAF6; BTAF1; BPTF; EVX1; NCOA6; PPARG; FOXI1; KDM4A; ZNF639; ZKSCAN7; BCL11A; PPARGC1A; CREBZF; MNX1; TCEA1; TBX4; ZSCAN32; CREBL2; EP300; SIX5; APBB1; ZFHX2; ELF1; SFMBT1; ERBB4; SP140L; NCOA2; HDAC11; ZHX2; BATF3; PAX8; ZNF217; NPAT; KLF15; ZNF160; E2F3; STAT2; ZNF408; TSC22D4; MGA; SAP130; ZNF211; CSDE1; TADA3; MAF; SSX3; ZNF771; ZNF586; ZZZ3; ETV7; ZNF107; ETV1; PRDM8; SMARCD2; CDK9; KLF1; ZNF253; SMAD4; PHOX2B; TAF1D; DNMT3B; GATA1; TRIM27; NKX3-2; CDK8; ARNT; PEX2; NPAS1; PHOX2A; CENPB; AIRE; TAF5; FUBP1; NFKB1; CDYL; JAK2; ONECUT2; ZNF212; HMG20A; IFNB1; ZNF324B; ZSCAN5A; ATF2; HABP4; IRF7; ZNF696; RAX; MMS19; ARHGAP35; NFE2L1; CALCOCO1; NEUROD6; ZNF443; ZNF140; ATF7IP; E2F8; ZNF512B; EHMT2; TLE4; MED7; TFEB; ZNF219; ZNF552; ZMYND8; ZNF276; ZNF331; AHR; IRF5; MTA2; ZNF419; ZNF611; LYL1; MED4; TULP1; IL16; TFDP3; NFX1; RSF1; SOX5; ZNF7; BLZF1; ZKSCAN5; TAF4; TCEA2; BCL10; HIPK1; MED12; HIVEP3; HOXA3; IRF1; ZFP64; ASH2L; EZH1; TSC22D3; HOXD3; IRF4; STAT6; THRAP3; SIM1; HTATIP2; ZMIZ1; MXI1; HEYL; ZNF446; NEUROD2; BLM; BATF; ARID5B; SNAI1; ZBTB25; ZBTB39; POU2F2; TBX19; CSDC2; RELA; TCF4; TBPL1; ZFP36L2; TAL1; TLX2; E2F6; MXD3; ZNF250; ZNF629; PIAS2; HAND2; ZBTB43; PDX1; SOX12; PSPC1; ELF2; ZNF544; ZNF134; ZSCAN12; SATB2; ZKSCAN3; ZNF783; RBPJL; TRPS1; TAF1C; SREBF2; TOX4; ERF; NSD1; TFE3; ZNF587; NFKB2; HLTF; ZNF236; TRIM32; GBX1; POU6F1; ZNF215; NHLH1; ESRRB; TBX6; BARX1; SSBP3; ZNF623; KLF10; ZEB2; ZNF778; TTF2; NFAT5; ZNF358; BIRC2; STAT5A; KDM5B; ZNF473; OVOL2; PEX14; LMCD1; TFAP4; ZNF224; RFX2; GON4L; ZNF197; ZNF133; MED20; STAT3; CBX2; TRIP11; GFI1B; ATF7; ZKSCAN1; ARID3B; MTF2; LHX5; MBD1; ZNF500; MBD4; SAP30; SMARCA2; YEATS2; ZBTB20; WT1; PRRX2; VEZF1; ZNF384; ZNF337; ZNF202; ZNF14; PEG3; EHF; THAP3; ZNF16; ZIM2; SMAD2; FOS; ZNF189; PAXBP1; CNOT2; ZNF665; MYB; BCL6; IKZF4; FOXC2; KLF9; ZNF239; ZNF93; POLR3F; ZNF35; ZFX; CHD3; RXRA; CREM; ZNF562; HOXB1; ZNF235; PLAGL2; HIF3A; DMTF1; MED1; TCF7L2; SP140; ESRRG; NLK; MLXIPL; RARA; SPEN; RFX5; GLI3; PROP1; ZNF24; ZNF44; MNDA; NRF1; PHF2; KMT2A; MDM2; NR5A1; ZNF45; MSC; MYRF; TLX1; CERS4; DEAF1; ZNF467; ZNF226; ZBTB1; TAF6; UBTF; KDM2A; PRDM10; ZNF79; ZBTB44; SUPT6H; ZNF302; JUNB; CHD7; ZSCAN9; PCGF2; LEF1; TRIM16; NR1I3; BRWD1; JUND; MAP3K10; CRX; ZNF33B; SP100; PRDM14; NFIX; OLIG2; SPI1; ETV5; RB1; PITX3; SOX21; FOXJ1; CIITA; ZNF248; SMARCA1; ZNF286A; MEF2D; ZNF264; PSMC3; NR2F1; TRIP4; HBP1; NFE2L3; ERCC2; TBL1XR1; SALL2; ZNF444; WHSC1L1; HHEX; SUPT4H1; HNF1B; ZNF816; LHX3; RREB1; WNT4; MEN1; ZNF506; MTA1; TP73; MYT1; ZNF154; ZBTB38; ZNF510; CIR1; NR6A1; SRCAP; DYRK1B; BBX; THAP11; BCL3; UIMC1; TCF15; FOXE1; LPIN2; TRIM24; FOXJ2; HDAC5; CNOT6; TCF7; DLX4; ZNF556; HIVEP1; SIN3B; CRYM; ADRB2; NRL; HAND1; HDAC9; ZNF124; NR3C2; CBX4; ARID3A; ZNF281; SAP18; HIVEP2; PLAG1; HESX1; HSF2; ZNF274; DBP; ATN1; PAWR; ESR1; STAT4; ZNF671; ZNF606; ZBTB18; TBX3; YEATS4; ZNF8; RUNX1; ATF1; TRAK1; PBRM1; ZNF200; FOXA2; BNC2; ZSCAN31; ZNF721; ZNF764; SMAD7; AR; ZNF263; TBX21; MECP2; ID4; DR1; RARG; OVOL1; ZNF423; ZNF91; SMARCA5; HOXC6; ZNF184; TLE2; JARID2; MLXIP; YBX2; ZFPM2; NCOA4; TFEC; BACH1; DNMT1; NR2F2; TRIP6; MEIS2; ZNF551; ZNF532; HLX; WDR77; NR1D2; SOX10; NCOA1; ZNF652; SETDB1; FOXO1; HLF; CUX1; REL; MEIS1; NFKBIB; TAF1; SUPT3H; AEBP1; PDLIM1; PRRX1; IRF9; NCOA3; TAF10; DNAJC1; ZNF117; NR4A1; PAX5; STAT1; PBX1; ZFHX4; ZNF267; SOX9; WWC1; TLE1; HOXA10; ZNF136; ZNF394; RORA; IKBKAP; ZNF43; CREB1; GATA3; TGFB1; BMI1; ZNF329; MAFB; ZNF148; EGR2; ZNF430; NRIP1; ZFP36L1; KDM5D; ZNF85; ZEB1
Down-regulation 214 CEBPB; GABPB1; ZBED4; ETS1; TCERG1; TFCP2L1; PCBD1; HMGA2; RBPMS; CCNE1; ZNF131; KLF6; GTF2IRD1; CEBPG; YBX3; HEY1; CENPF; CDK7; SUB1; IRX4; MNT; TCF7L1; CEBPD; EGR4; RNF138; PTTG1; TEAD4; HSBP1; FOXM1; HMGN3; SIM2; AFF4; MED21; MYCBP; ILF2; HIRA; RAN; SUPT5H; TFDP1; PFDN5; BTF3; CCNA2; AIP; RUVBL2; RYBP; CCNC; IRF3; CEBPZ; MED24; ZNF165; MDM4; NPM1; KAT6B; MYC; URI1; RBBP7; ASCL1; HDAC1; HDAC2; UBE2I; FOXN2; CUX2; FOXG1; CAPN15; GMNN; CRK; ZNF432; CREG1; SOX15; MECOM; YBX1; LZTS1; ENY2; MNAT1; CARM1; TAF12; CBX5; SUZ12; ZNF10; TFAM; HMGB3; TAF9B; NCOR1; PQBP1; SALL1; PSIP1; HOXB6; ZFHX3; SOX11; DRAP1; ZXDB; ZNF460; FOXD1; CCDC59; VPS72; TOX; NFIL3; MED14; ATF4; PAX9; CBFB; C1QBP; MTDH; MYBL1; EMX2; USP22; YWHAB; TDP2; PMF1; HIPK3; TAF1A; NCOR2; NHLH2; HOXB9; LOXL2; NR1H3; RUVBL1; ZBED1; HOXA1; HMG20B; SNAI2; ST18; TAF7; HOXA7; RNF4; FOSL1; TRIM28; TAF9; ID1; TCF3; SIX1; NFKBIA; NR1H2; BRD4; MED16; GABPA; HDGF; POU3F2; CREB5; SIRT2; FOXJ3; CBFA2T3; TULP3; BAZ1B; HOXD10; CDIP1; BAZ1A; ZNF593; DEK; ZNF711; NFYA; TBL1X; MYBL2; SUMO1; SFPQ; ZNF573; RBM14; KLF4; NFATC3; PIR; PRKDC; SMAD1; KLF5; NR1I2; BHLHE41; GTF2A2; XBP1; HOXA5; HOXB7; RBPJ; PCGF1; HOXD11; EZH2; ID3; ZNF529; MXD1; FOXA1; SOX13; FOXF2; MSX1; MAX; IFI16; XRCC6; FOXF1; PUF60; HNRNPD; VDR; ZNF589; MBD2; HDAC4; NR2E1; NFIB; ETS2; MAFF; SSRP1; TFDP2; ZIC1; HIF1A; CD3D; ARID4B; TGFB1I1; ARL2BP; RBFOX2; NR4A3; TFAP2A; TXNIP; FOSB; SMARCB1; INSR; TRIM29; ARNTL2; HOXB5; TWIST1; BCL11B