Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16574 Pf-477736 GSE70138 MCF10A Human 3h 3.33uM EID0007
Types Number Response transcription factors
Up-regulation 486 NR4A2; KAT7; HDAC6; HABP4; FOXO4; CEBPZ; HMGXB3; TFE3; MYCL; MKL1; CREB3L1; HOXB13; RARA; PPARGC1A; ZNF175; PIAS2; ZBED1; ZNF235; SETD3; ZIC1; MAK; EZH2; ARID3B; SP2; CDYL; TCFL5; DDX5; IRF9; ZNF444; ZBTB39; NFE2L3; HIVEP3; ZNF331; HIPK1; IRF8; RNF2; STAT2; ZKSCAN5; ZNF586; ALX1; HCFC2; TRAF6; ZBTB40; SETD2; LIMD1; PKNOX2; CCNH; PLAGL1; OVOL2; FOXJ1; BRD3; POU2F2; NR3C2; LHX2; DLX4; SOX4; FOXN3; ELK1; SKI; CREM; ZNF507; DNMT3B; ZKSCAN3; EZH1; ZNF589; SUPT7L; SIX3; RUNX3; KLF4; ZNF165; MBD1; EED; ING2; ZNF552; TFAP4; SPDEF; POU3F1; SOX5; CDK2; PPARG; BRPF1; ZNF211; RXRA; NHLH1; AHR; ZNF180; PAWR; SMARCA1; NFRKB; HIVEP1; ZFHX2; ZBED4; SALL2; REPIN1; ING1; NFKB2; POU6F1; OLIG2; MYOG; CRY1; ZNF711; TAF4B; NFAT5; IRF4; YBX2; MAML1; RERE; TSC22D4; NKX2-2; SAP30; ELF2; ZNF710; SAP18; PHF8; ZSCAN16; SALL1; ZBTB43; TXNIP; KLF11; ETV5; CRYM; SP1; RFX2; ZNF467; WHSC1L1; TADA3; ZSCAN5A; NR1I3; NR0B1; SOX13; THRB; ZBTB38; MAGED1; NANOG; HMBOX1; NRF1; POU2F1; ARID4A; KDM5B; CTR9; ZNF606; ZNF208; ZEB2; MYOD1; SSX3; BCOR; CRTC1; HOXC11; TRIM16; ZKSCAN7; BCL6; THAP3; BIRC2; SNAI1; SAP130; SUV39H1; PHOX2B; PPARD; NR5A2; KLF9; RBPJL; IRF7; CDX2; ZNF783; CNOT6; SATB2; AGO2; ZSCAN12; HOXC13; PRDM14; TFDP3; HSF2; GATA2; PIR; ZNF350; TAF5; THRA; DACH1; MSC; NR1I2; SUPT5H; ZBTB18; TRIP6; TUB; IKZF4; JAK2; ZXDC; VDR; ZNF721; GON4L; JUND; PBX3; ZNF143; ZNF816; ZBTB20; PATZ1; HLF; ZIM2; TAF4; SP110; EBF2; STAT3; CHD7; HDAC11; MNX1; ZNF227; ZNF239; ZNF215; RARB; CIITA; HMGA2; TCEA2; LHX3; STAT5A; MAF; BRD7; ETV1; ZNF510; ZNF419; KLF15; LMCD1; ZNF154; KMT2B; MLLT10; CREBL2; KAT6B; HESX1; IRF5; ZNF667; ZKSCAN4; SKIL; BACH1; TSC22D3; SPEN; POU4F2; RBM14; HEY2; THAP10; MED12; HLX; MAFG; ARNT; NR6A1; ZNF329; SMAD6; ZNF639; TULP2; ZFHX3; NCOA3; MED14; ZNF835; ZNF253; ZNF587; ZBTB25; ZMIZ2; ZMYND11; ETS2; ZNF224; BANP; PAX8; BRWD1; CIC; LHX6; TOB1; FOXI1; ZNF33B; ZNF276; ZNF665; ERG; ADRB2; PAX1; PBXIP1; SOX12; PKNOX1; ZSCAN18; LIN28A; GBX1; NR1H2; GLI1; PEG3; ZNF34; ZNF536; PHF1; JARID2; FOS; ZNF45; ZNF84; SREBF2; TSC22D2; HTATIP2; SMAD4; ZNF286A; HINFP; MYB; WHSC1; TSHZ2; ZNF112; MBD4; NFYC; CBFA2T3; ZIC3; CNOT3; VGLL1; NR1D2; ZNF302; CDK9; MYRF; ZNF134; SSX1; PRDM2; CCNT1; PAX6; ZNF160; TRRAP; PAXBP1; ZNF423; CSDE1; ZNF614; SP4; TCF4; NCOA1; DAXX; ASCL3; RRN3; HMGB2; CASZ1; PROP1; ZNF222; CSDC2; RING1; FOXA2; ZNF8; BLM; FOXG1; CBX2; TRIM25; NAB2; GATA1; GATA6; TAF1C; ZFPM2; HOXC5; ERCC2; IFNB1; MYT1; TCF7; ATF7IP; DNMT1; ZBTB24; EHMT2; CHD2; MGA; TBPL1; BPTF; ZNF556; NLK; SP3; MZF1; MED13; LPIN2; NUP62; IKZF5; ZNF324B; FOXH1; EYA2; ZNF35; MYCN; GTF2I; HIPK3; SSBP3; TBX21; BRIP1; POU5F1B; SOX17; ZNF506; KDM5D; AEBP1; EP300; HOXD3; NKX2-1; ZNF264; SPIB; RNF141; HSBP1; CDK8; TAF1; JUNB; TOX; BCL11A; HOXB5; SFMBT1; TGIF1; ZNF93; TCF7L1; ZNF443; NR4A1; TFEB; ZNF778; KDM4A; MYBL1; ZNF580; FOXN2; CCNE1; ZNF629; NFKB1; MTA1; EHF; CREB1; CALCOCO1; CTNNB1; FOSL2; ZNF415; RBBP5; WWC1; SOX10; RORA; NFKBIB; ATF3; REST; ARNTL; RSF1; ZNF394; MITF; BBX; CTBP2; MEOX2; SUPT3H; PLAG1; RREB1; ZNF528; TSC22D1; ERBB4; ZNF611; HOXB7; CDX1; NR2F1; ZNF136; PRRX2; BHLHE40; MTF2; TLE1; FOXF1; DEAF1; THAP11; ZNF189; BASP1; URI1; OSR2; CARHSP1; ZNF273; ID4; FOXE1; EGR2; ELF3; ID2; HHEX; SERTAD2; TRIM24; ZNF354A; TTF1; PSPC1; ZNF184; ZNF148; GRHL2; TFDP2; TLE2; NFATC3; ZFP36L1; ISL1; REL; GATA3; NR4A3; MEF2C; LEF1; ZNF551; MECOM; ZNF274; ZKSCAN1; FOXF2; FOXJ3; ZNF652; ABL1; IKZF1; ZNF43; TOX3; MAFB
Down-regulation 212 PSMD9; PITX1; CEBPB; TCEA1; YBX3; PFDN5; POU2AF1; PCBD1; ZNF410; NR1H3; ZNF593; RNF10; NFIB; MED15; EGR1; CCNC; MYCBP; FHL2; MTDH; THAP7; UBE2I; RNF14; NFATC4; PDLIM1; RBM39; GLI3; FLNA; NFIL3; PCGF1; SND1; BAZ1B; ITGB3BP; IFI16; SOX15; AATF; MED24; BCL10; APEX1; HDAC2; FOXO3; KAT8; TAF10; HOXD10; ZNF83; HIRA; NPM1; LZTS1; AIP; FOSL1; PAX5; CREG1; PAX9; MLX; RNF138; BTF3; TP63; EGR4; TADA2A; PITX2; DLX2; COPS2; GTF3A; ABT1; ID1; RAN; TBL1XR1; HOXD11; WWTR1; ILF2; TBP; PPRC1; CREB5; NFKBIA; ATF6; TSG101; CDK7; GABPB1; ZMIZ1; ZFP36L2; SMARCD2; NFIC; KAT5; MYC; CEBPG; BAZ1A; ERF; RBBP8; HOXD12; MED17; ZNF24; ZNF131; SMARCC1; CCDC59; INSR; DPF2; GTF2A2; NR2F6; TAF1D; HDAC1; SOX9; MYBL2; ESR1; ASCL1; HMG20A; THAP4; IRX5; PEX2; NEUROG2; CHD8; CAPN15; GTF2IRD1; TRPS1; ARID5A; MBD2; SPI1; ZNF576; UBE2L3; VPS72; BACH2; TCERG1; SMAD1; PQBP1; TRIM29; FEZF2; PSMC3; SSRP1; ZBED2; NEDD8; STAT6; MKL2; E2F2; NAB1; PRKDC; HDGF; SCAND1; SIX6; CUX1; ESRRA; USP21; ID3; MEIS2; ELK3; RBFOX2; GMNN; DDIT3; BTG1; TAF9B; XBP1; CCNA2; EPAS1; HOXA5; ECD; YEATS4; COPS5; FOXA1; RUVBL1; NCOR2; YAP1; HAND1; MED21; SP140; PGR; MAX; YBX1; AES; NONO; NCOA4; ZNF195; ELF1; TERF2; ZNF12; SUMO1; PIAS1; NR1H4; C1QBP; ZNF573; SRF; SIX2; CARM1; MEN1; ARL2BP; MLXIP; NR2E1; TGFB1I1; TULP3; RNF6; BMI1; RFX5; ATF4; PA2G4; MAFF; CREB3L2; ARID5B; CALR; HEY1; ERBB2; LOXL2; SMARCB1; ZNF232; HMGB1; ING3; ARNTL2; TRIM22; HMGB3; FOXC1; MSX1; HOXC6; SNAI2; ARNT2; FOSB; HOXD1; TRIB3