Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16513 Gsk-1059615 GSE70138 MCF10A Human 3h 1.11uM EID0007
Types Number Response transcription factors
Up-regulation 503 HLTF; SLC2A4RG; KAT7; KLF12; CHD3; JUN; FOXO4; REPIN1; CCNE1; EYA2; NR2F2; ARID4A; GATA4; ING1; ZNF711; MDM2; TCF25; TSC22D1; POU6F1; CREB3L1; DAXX; SMARCD3; FOXL2; TRIM32; GATA2; ELK1; CBX6; RXRB; BRPF1; HMGB2; CUX1; OLIG2; SKI; CTR9; HOXC10; HSF2; SMARCA1; HABP4; RUNX3; ATF7IP; TCFL5; BRD3; PHF1; NFKB2; HOXC6; NKX3-2; ZNF212; BRF2; TAF4; SOX30; ZBTB39; RERE; ZMIZ2; NR1I3; TFCP2; MED23; E2F2; NR4A2; BHLHE40; SETD3; WHSC1L1; NFAT5; ESR2; CIZ1; HMGXB3; RNF141; ARID1A; SMARCA4; ZNF492; ZNF552; CBX7; ELK4; TRIM16; SPDEF; PRMT2; ZNF384; PHF8; ZMYND11; FOXI1; MXD4; SSBP3; FOXC1; SIM2; DDX54; AFF1; PPARD; EN2; MAML1; ZNF512B; SHOX; ZNF76; PAX8; SSX1; ZNF646; RING1; PCGF2; TADA3; TP53; ZNF292; SALL1; MSC; NKX2-8; NFIL3; RFXAP; SREBF2; MGA; DMTF1; ZFHX2; NRF1; TADA2A; NR3C2; MAGED1; TFAP4; PIAS2; TLX1; ZBTB48; SOX9; STAT2; RARA; PKNOX1; CBFA2T3; ZHX2; CITED2; IKZF2; CENPB; DEAF1; PFDN5; NAB2; ZKSCAN7; SOX12; GLI1; ZNF507; NLK; KDM2A; THRA; TAF7L; NHLH1; PBX2; BAZ2B; SP1; SFMBT1; NSD1; LZTR1; SCMH1; LHX1; ZNF208; ZNF205; ELF3; ADNP; NFRKB; DNMT3B; STAT3; BRDT; ZBTB18; POLR2A; TAF1C; NCOR2; CIC; SIAH2; UBP1; TSC22D3; NKX2-2; MITF; MTA1; ZBTB40; UBTF; ZNF276; HDAC7; ZNF506; PAX2; ZNF286A; MED7; NFYC; WT1; SMARCD1; CTBP2; MYOD1; MED12; CLOCK; TGFB1I1; TRIM24; RARB; THAP7; MLXIPL; KAT6A; EZH1; EVX1; POU2F2; ZNF226; NR1H3; ELF2; SAFB2; KAT6B; PCBD1; ZEB2; ZNF287; DMRT1; RCOR1; HEY2; TBL1X; SIM1; SIX5; CEBPA; TFE3; PKNOX2; TFEC; HOXC4; KDM5B; ARHGAP35; ZHX3; HCFC1; PIAS3; ITGB3BP; SUV39H2; SIN3B; RBPMS; MYRF; ETV5; ZBTB20; ASH1L; HIVEP2; MYBL1; YBX2; CDK9; CBX5; URI1; SMARCA5; CALCOCO1; LHX5; HOXB3; SNAI1; ARID3A; OSR2; ZNF157; THRAP3; ZNF556; TCF15; WNT4; BCL3; EP400; TEAD3; TCF3; NELFB; ZNF324; TSC22D4; ZNF493; E2F3; CDK2; ZNF236; ZNF580; POU2F3; SCAI; BRWD1; PEG3; HOXC5; KMT2A; RSF1; YEATS2; ZBTB44; MTA2; LEF1; FOSL2; MYOG; NKX3-1; PRDM5; SAP30; THAP11; SMAD1; GRHL2; MEF2D; ZFY; MEN1; SMARCC2; SP2; CREBZF; NFKBIB; NCOA6; WWP1; HDAC6; GABPB1; ARNT; NKX6-1; MNX1; APBB1; ETV1; ESR1; GTF2F1; ZBTB6; ZSCAN31; SOX3; EHMT1; FOXO3; ZNF189; EMX1; ZNF696; RBBP5; PBXIP1; AR; RNF111; SNAPC4; ZNF529; HNF4A; MNDA; EMX2; TAF6L; DRAP1; HOXC11; ZNF345; NEUROD2; DNAJC1; HDAC4; LOXL2; NCOA1; CBL; TXNIP; E2F6; ARID5B; SSX7; ZNF224; RFX7; IKZF4; PATZ1; ZNF257; LPIN2; SP3; TBPL1; GTF2I; TLE2; LIMD1; MLLT10; CNOT6; ZNF135; TEAD1; ZNF442; GLI3; DLX4; ZNF528; RELB; SATB1; MEF2A; HDAC5; ERCC3; RBM14; ZKSCAN8; TRRAP; HOXA4; KDM4A; POU4F1; TAF11; LHX2; NR2F1; MBD4; FOXN3; ZNF587; ZIC1; NFKB1; ZNF324B; SOX5; LMX1B; SUPT6H; PRRX1; ALX1; TERF2; MYT1L; ZIM2; POU4F2; ZNF778; PSIP1; DLX5; ZNF710; ATF1; HOXA3; GATA6; PURA; KMT5A; BANP; TAF9B; FLNA; ZNF358; CARHSP1; CREBL2; HOXA1; MDM4; AGO2; MXD3; HMGA1; TRIM22; EDF1; GLI2; WWC1; ZXDC; STAT5A; NEUROD6; CRK; SSX3; PRRX2; TGIF2; SMARCA2; USF2; TAF4B; BRD8; ZKSCAN4; ZNF764; MXD1; SNIP1; BCL6; MECP2; ZNF516; ZNF835; BNC2; TRIM25; MAZ; MED1; ZNF671; ID4; MLXIP; KLF2; PRDM2; ZNF274; AES; GBX1; STAT5B; ZNF652; ZNF629; LHX6; PSPC1; CAMTA2; TAF6; ZNF467; ETV6; CSDC2; IRF5; SOX4; ZBTB24; JARID2; NEUROG1; ZNF264; HLF; PARP1; PHF20; IRX5; MYCN; ING4; FHL2; TCF7; NR0B1; ASH2L; ZNF443; CBX4; SUV39H1; ZSCAN18; PHIP; ZNF329; NONO; NUP62; ZNF227; TSC22D2; TULP4; NPAT; BASP1; HSBP1; HOXD3; HMG20B; TDRD3; IRF8; MEIS2; TOX3; MEF2C; CRYM; CIR1; TAF10; ERBB4; HES1; LMCD1; TAF7; MSX1; FOSB; PTTG1; TBX3; HOXA5; HLX; HIC2; SFPQ; TFDP2; HOXB2; DBP; MYB; BCL11A; MAF; IRF7; CREM; CALR; ZNF148; ZNF45; IKZF1; KDM5D; MECOM; AEBP1; HOXB7; ZNF136; MAFB; BCL11B; ZNF91
Down-regulation 257 RNF138; TCEA1; CNBP; PQBP1; PUF60; CEBPB; RYBP; KLF5; ZBED2; ETS1; ATF3; MED17; MYCBP; ZNF432; YBX3; ID1; HDAC2; C1QBP; TTF2; MED27; THAP4; CERS6; ZBTB11; ETS2; GTF2IRD1; ZBTB1; ATF5; CCNC; SOX15; RAD21; PSMC3; KLF7; RNF4; MYBL2; ZFP36L2; ID3; TRIM29; RBM39; CDC5L; PPRC1; TP63; BRCA2; DDIT3; IRX4; IRF3; ZNF593; ILF2; PBX3; BRCA1; ERF; PSMC3IP; POU2AF1; FOSL1; ZNF250; PCGF1; UBE2I; NFIB; MEOX2; LDB1; ZNF195; FOXO1; GTF2A2; RNF6; OVOL2; YAP1; TAF9; PEX2; ATF6; PPP1R13L; HMGB1; JUP; ZNF410; FOXA2; ZNF589; ZNF232; CNOT2; CEBPG; RAN; COPS5; BCOR; TFAM; DACH1; UTF1; PDLIM1; CDX1; RXRG; SIX3; EED; XRCC6; ZNF24; CREB1; NRIP1; YEATS4; HDAC3; INSM1; PMF1; TERF1; SMARCE1; POLR3C; VPS72; ZNF180; RUVBL1; ETV4; PMS1; ARNTL2; ACTL6A; ELF4; TEAD4; PRDM1; GMNN; CAMTA1; ISL1; NR2F6; WDR77; CNOT1; ZNF669; BIRC2; CHD7; CTCF; HMGB3; RCOR3; CBFB; ZNF544; JUNB; IRF6; ZNF10; CDX2; ZNF140; FOS; ORC2; PRDM14; ADNP2; SMAD7; ZNF562; HMGN3; EHF; ZNF12; BTF3; EN1; RB1; IKBKAP; ZMIZ1; NKX2-1; ZNF124; PTRF; CEBPZ; SERTAD2; ZNF654; NFKBIA; HIF1A; CREB3; ZNF668; BATF3; ZNF131; SNAI2; KAT8; RFXANK; TOX; ZNF219; KLF10; USP21; IRF4; LIN28A; VGLL4; HBP1; ZNF165; MED14; RUNX1; KDM4C; ZNF22; CCDC59; HDAC9; RFC1; TAL1; ACTL6B; BRD4; CREG1; PAX5; IFI16; CSDE1; NR4A3; TCEB2; EYA1; TAF1D; PBRM1; NR1I2; SUMO1; BBX; ZFX; TRIB3; CBFA2T2; MED6; TFAP2A; NFATC3; ZFHX4; PHOX2A; PLAGL1; SMARCC1; TRAK1; KLF9; ZBTB38; LHX3; MAFF; HOXA11; VDR; ZNF273; NANOG; CEBPD; HDGF; DR1; DLX2; NCOA2; FOXN2; MTDH; KLF3; HEY1; ZNF532; CREB3L2; ARL2BP; IRF1; RUVBL2; FOXK2; CRY1; ST18; APEX1; CTBP1; MXI1; ENO1; MTF2; MYC; SOX11; DEK; MEOX1; SUPT3H; RBFOX2; ARNT2; GTF3A; HIRA; ENY2; AHR; ING3; TOB1; HOXA10; KLF4; ZBTB16; PRKDC; CD3D; ATF4; TCF7L2; TBX2; FOXF2; STAT1; TWIST1; CCNA2; HOXD1; ZNF85; ZNF430