Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16271 Mitoxantrone GSE70138 MCF10A Human 24h 3.33uM EID0005
Types Number Response transcription factors
Up-regulation 160 NR3C1; CALCOCO1; PBXIP1; ZNF611; RBBP5; TRIM16; ZNF160; MXD4; MDM2; FHL2; PNRC1; ZNF337; TRIM22; STAT2; L3MBTL1; ZNF83; HBP1; ZNF79; TBX3; ZNF721; ZNF665; AES; DMTF1; ZNF536; ZNF224; IRF9; ZNF44; SOX4; IRF7; SP110; TSC22D3; REL; ZNF3; SOX9; CBX7; IRF6; ARID5B; BTG1; TRIM29; BLZF1; TCEB2; ZKSCAN1; PAX8; PHF1; ZNF652; MAF; ZNF195; NR5A1; TP63; JUP; ING4; CDIP1; MNT; ARID5A; ZNF136; ZNF573; BAZ2B; ZNF112; ZNF268; ZNF432; MDM4; TAF7; NR1D2; SRCAP; MKL1; CUX2; ZSCAN31; NR1H2; ZNF345; PHF20; RUNX1; CREBL2; ZNF426; ZNF226; ZNF350; HIVEP1; ZNF358; NFAT5; NAB2; TLE2; ATF3; ST18; CARF; CUX1; ZNF430; SIN3B; ID3; SMAD3; PEX14; ZNF667; JUNB; BCL3; ZBTB20; ZNF593; ZBED2; MXI1; ZNF91; ZNF544; GATA6; PEG3; HTATIP2; ZMYND8; CTNNB1; NEUROD1; ZNF117; NR0B1; BCL11A; CREB5; DACH1; ZNF43; ZNF12; NKX2-1; NCOA2; ZNF512B; DDX5; HLF; ZNF623; TAF1D; STAT4; CREB3; WNT4; STAT1; OSR2; ZNF415; HDAC4; ID2; CERS4; SNAI2; ZIC1; DLX5; FOXF2; HDAC9; SMARCA1; SMAD6; TXNIP; FOSB; AHR; MEIS1; FLNA; NKX3-1; ID1; BCL6; KLF5; BASP1; BHLHE41; ELF3; ID4; TGFB1; RELB; NR4A2; SCAND1; HOXD1; IRF1; INSM1; PBX1; ARNT2; TSC22D1; FOS; MEIS2; FOXO4
Down-regulation 96 PCBD1; CCNA2; TFDP1; DNMT1; EZH2; MYBL2; FOXM1; CENPF; HMGB2; MYC; CEBPD; CHAF1B; WHSC1; SSRP1; SMARCC1; PARP1; HDAC2; CDK2; CBX5; BRCA1; TAF5; BLM; DEK; TFAM; YEATS4; ADNP2; CCDC59; RUVBL1; RHOA; PSMC3IP; BIRC2; RNF138; RBM14; SETD2; RAN; HNRNPD; BAZ1B; PTTG1; WDHD1; CHD7; PA2G4; GMNN; ZEB1; NUP62; SUB1; HOXC6; TRIM28; C1QBP; RUVBL2; NPM1; CBFB; CEBPG; HOXC10; BRD7; CARM1; BCLAF1; AGO2; RB1; BRD3; TULP4; ECD; TAF9B; ISL1; RBBP7; MLXIP; HMGB1; SAP30; TEAD4; HOXC4; RBBP8; BATF3; NFYB; CCNC; NFATC1; SMAD1; ARNTL; COPS2; BMI1; ENO1; SUV39H1; ILF2; ELF5; ZHX2; RBPMS; SFPQ; HLTF; HOXB7; PITX1; NR2F2; PURA; LEF1; KLF9; CREB1; STAT5B; SATB1; MAFB