Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16251 Linsitinib GSE70138 MCF10A Human 24h 0.12uM EID0005
Types Number Response transcription factors
Up-regulation 57 PAX8; DACH1; CEBPD; ZBTB38; ZMYM2; TADA3; TXNIP; MLXIP; ZNF24; TBX2; ERBB4; HOXB5; ZNF443; MEIS1; CBX3; PFDN5; HOXB6; PROX1; HOXB7; ZBED2; BASP1; CREBL2; AHR; VEZF1; RNF141; HOXB2; TFEC; NR2F1; NR2F2; ZNF91; ZBTB20; SALL1; MYCN; ZEB2; EMX2; SAP30; TOX3; HEY2; EGR3; HMGB3; IRF6; MITF; ESR1; SPDEF; HLTF; MAF; ID4; TBX3; ASCL1; KLF4; PURA; SATB1; LEF1; WT1; TSC22D1; MAFB; ID1
Down-regulation 27 ADNP2; SNAPC4; MDM4; FOXI1; POU2AF1; ETV5; TCF21; RUNX3; MEF2A; TWIST1; MYRF; RCOR1; FLNA; TGFB1; PITX2; POU4F1; GATA6; TRIB3; TCF7L1; SCAND1; MEIS2; TCF4; ARNT2; MYB; BHLHE41; NFATC4; FOS