Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16129 Pf-431396 GSE70138 MCF10A Human 24h 10uM EID0005
Types Number Response transcription factors
Up-regulation 669 EGR1; LHX3; PRDM14; SHOX; ERBB4; RFX1; ZNF701; GLI2; RFX3; ZNF154; EP300; ZNF816; THRB; HOXD3; HOXC8; CALCOCO1; DLX5; FOXH1; NR6A1; SOX18; ZNF223; CHD2; ZNF117; ARID5B; ZBTB48; NRL; SSX7; SOX17; ZNF682; ZNF331; NEUROD4; CAMTA2; ASCL3; SOHLH2; ZSCAN2; ZIC3; ESR1; ZNF440; IKZF3; ZNF586; CBX2; ZNF221; HBP1; TWIST1; NEUROG2; VENTX; FEZF2; ALX4; LIN28A; POU6F2; WHSC1L1; ZNF550; SOX1; POU6F1; ZNF75D; ZNF536; PRDM9; ID4; PRDM1; ZNF695; ZNF350; TBX5; SRY; FOXE3; ZSCAN18; MXD4; DLX6; ATOH1; PRDM2; EZH1; CDIP1; PRDM5; ZNF442; HES2; ZNF33B; ZNF268; NOCT; ZBTB44; SP4; E4F1; MED31; HOXB8; CDX4; ZNF507; ZKSCAN8; ESRRB; PAX7; ZNF44; AFF2; ZNF467; ZNF549; SALL2; SUPT7L; ZNF667; OVOL2; HOXD1; IKZF2; TBX1; MAML3; ZNF391; HNF1B; SOX3; CIITA; PAX8; GRIP1; OVOL1; CBFA2T3; EMX1; TFDP3; HOXD12; ZKSCAN4; IRF9; SCRT1; SOX21; ZSCAN9; PAX1; TULP2; ZNF239; ZNF254; RORB; HOXB1; NEUROD2; ZNF814; ZNF180; BARX1; ZNF345; GSC2; SPI1; E2F2; POU3F3; ZNF778; ZNF571; ZNF493; NEUROG3; ZNF688; NR5A1; MED25; ZNF257; CRX; NR4A3; MECP2; DLX4; SRCAP; ZNF749; ZNF500; ZNF142; ZNF235; ZNF606; STAT2; SUPT3H; ZIC4; NHLH1; ZNF14; FOXD3; CBX7; SOX14; NFIX; NEUROD1; E2F5; ZFP2; SIX3; RING1; CBX4; ZNF556; ZNF225; NR4A1; ING4; LMX1B; MAPK8IP1; NEUROG1; MED12; ONECUT2; BNC2; ZNF611; ZNF132; L3MBTL1; ZNF665; ZNF250; SMAD6; ZNF304; ZBTB3; ZNF471; ST18; ZNF423; DOT1L; ZNF157; ZNF81; ZNF80; BRDT; ZNF768; ID3; POU1F1; TBX6; HDAC5; ARID3B; GCM2; GBX2; HINFP; ZNF573; NR1H2; KLF13; THRA; HNF4G; NFKB2; AR; ZNF419; NR1I3; ZNF770; ZIM2; RARG; ZNF140; ZNF174; UTF1; ZNF711; PAX4; ZNF674; RBPJL; SCAI; MECOM; SOX2; CREBL2; ZKSCAN3; PHF1; SOX5; POU3F4; ZNF492; ZXDC; POU2F3; TFDP2; HESX1; ZNF415; VHL; ZNF141; NKX2-1; ZNF780B; NEUROD6; JUN; EYA3; ZNF407; CEBPD; NACA2; HIF3A; ETV3; LZTR1; DCC; NFIC; ZNF835; PAX3; SSBP3; CD3D; HAND1; ZNF136; PROP1; ZNF329; GATA1; THAP9; IFNB1; ZNF613; CREM; PRDM16; LHX6; BRWD1; HEYL; DYRK1B; GRHL2; ZNF253; TBR1; TUB; KAT2B; ZFPM2; ZNF675; PRDM12; TAF1C; ZNF10; GFI1B; CARF; ONECUT1; AFF3; ZNF529; HNF4A; CUX2; ZNF654; ASCL2; E2F4; HOXD9; PLAG1; ARID3A; HIC1; CBFA2T2; VGLL1; DLX2; LBX1; TBX21; AIRE; MSX2; ZNF273; NCOA2; TULP1; ZNF671; TBL1Y; ZFP37; ZNF91; RFX2; GBX1; TLX2; ALX3; TEF; TXNIP; FOXD2; MAP3K10; TAF6L; ZNF177; FOXL1; ZNF214; ZNF41; TAF4B; ZNF43; ATF6B; TBX19; POU5F1B; ZNF532; MBD4; PBXIP1; NAB2; TAF7L; RXRG; ZFP69B; TP73; STAT4; ZNF184; HOXA6; ZNF112; SKI; ZNF343; NR4A2; ZNF215; ZXDB; MEF2C; MYT1; ZNF506; SKIL; ZNF34; SSX3; POU4F3; PAX2; KLF8; ZNF287; ZNF155; ZNF460; BNC1; REL; GCM1; MAFK; MLLT1; MYCN; ZNF480; PDX1; KLF15; ZSCAN32; FOXB1; MYEF2; CIR1; FOXN1; TERF1; NKX6-1; FOXE1; ZNF79; ZNF208; SIM1; ZNF362; SP140; FUBP1; TLX3; SIX6; NR2C2; ZNF85; NR5A2; GATA2; ZNF623; TGIF2; MEOX1; BACH1; ZNF195; ZNF234; PRDM10; TLE2; GMEB1; NANOG; ZBED2; ZNF764; TSHZ2; GFI1; VAX2; NHLH2; MSX1; PBX2; TCEA2; KDM5C; SNAI1; KMT2D; CDX1; PRDM13; HIC2; THAP7; PKNOX2; BARX2; ZNF771; ZNF135; PHOX2A; PPARA; ASH1L; DBP; ZFHX2; ZBTB17; YEATS2; HAND2; TRPS1; WNT4; ZNF165; NPAS1; ACTL6B; MYCL; PAX6; SNAPC4; FOXI1; ESR2; CREB3L2; ARID5A; DAXX; CCNE1; MZF1; MYF5; ATF3; NR0B2; FOXC2; EGR4; KLF12; NR2E1; ZEB1; VPS72; HOXA2; ZNF83; ZBTB7B; HOXA3; ZBTB7C; RAX; HHEX; NKX2-5; NR0B1; HSF4; MKL2; HEY1; KLF1; SUPT5H; KLF3; HOXD13; TFEC; SALL1; RORC; ZNF74; ZNF248; TFAP2B; ZNF552; BPTF; ARRB1; OLIG2; TCF4; TRIM33; ZBTB43; HABP4; THAP10; POU4F2; CCNT1; JUNB; EMX2; BHLHE41; HOXC5; FHL5; MXD1; ZNF222; GCFC2; SUMO1; CEBPE; HDAC6; ZNF175; ZNF93; HDAC9; TULP3; MDM4; BCL11A; SMARCA1; TBX4; ETV2; SIN3B; SUV39H2; MEIS2; CITED2; PITX2; TLX1; ZBTB6; SHOX2; PRRX1; ZNF84; TGFB1; EN2; FOXJ1; SOX30; WT1; ZNF562; ZNF710; ATN1; PIAS4; ZKSCAN7; FOSB; ZFY; IKZF1; NR1H4; SETDB1; ANKRD1; ZSCAN31; ZNF557; LDB1; LHX2; BRF2; CSDC2; TRIM24; MXI1; HOXB5; MYBL1; IRF6; MXD3; ELF2; NFATC4; RARB; ZFP30; TAL1; NKX3-2; LZTS1; IRF3; TCF21; ZNF107; FOS; CERS4; DMRT1; ZNF813; RSF1; HEY2; TRIB3; TFAP2A; PEG3; MAK; GATA6; ZMIZ1; SSX1; MYNN; LYL1; PCGF3; POU2F2; ZHX2; ZNF264; FOXL2; FLI1; NR1I2; OSR2; LMCD1; LITAF; ZNF468; ZNF133; ZNF334; HOXB13; ZNF444; KLF7; MEOX2; ZNF224; SPIB; EGR2; PITX3; ELF4; CDX2; HOXD10; BCL6; EGR3; TOX; CREB5; NFAT5; PEX2; PAWR; AEBP1; NFE2; TBX3; EBF2; ARNT; ZNF587; BACH2; KLF11; ARL2BP; PEX14; DACH1; HLX; ZNF232; NR1H3; TCEA1; EYA1; ZSCAN16; TAF11; SOX13; FOXF1; ZNF124; IRF7; ZNF589; NR3C2; CALR; EPAS1; HSF1; HOXD11; ID1; HIPK2; FOXG1; TCF7L1; ISL1; GLI3; INSM1; AES; SSBP2; SP140L; SPDEF; SNAI2; IRF1; FOXF2; NKX2-2; FOXN3; TTF2; PGR; MYRF; ZNF426; NR2C1; ZNF512B; CRYM; NFE2L3; SOX11; CNOT3; HMBOX1; PRRX2; CBX6; RBFOX2; INSR; SMAD7; NFATC3; JUP; DMTF1; KLF4; POU2AF1; HOXB2; KLF10; ARNT2; POU4F1; PLAGL1; AHR; ASCL1; ZNF22; MNDA; FOSL2; MAF; TFAP2C; TRIM22; MAFB; PBX1; FOXO4; TBX2
Down-regulation 201 USP22; FOSL1; MYC; CRK; ADRB2; HOXA5; FHL2; CCNA2; ATF6; SMARCC1; VGLL4; HDAC2; TCERG1; AATF; NUP62; RBBP4; NCOA6; TBP; MBD2; BAZ1A; CDK7; SNW1; MED6; TFDP1; UBE2I; NELFB; RBM14; RAN; CNOT1; GTF2A2; TRIP6; TRIM16; CENPF; SMARCE1; SSRP1; MED1; SMARCA2; CENPB; SAP30; HOXB7; PA2G4; TRIM28; MLX; NPM1; ATF1; FOXO3; XBP1; SFPQ; PATZ1; SETD3; DNAJC2; YWHAB; ZFP64; ELF1; YBX3; ATF4; HOXC6; PTTG1; HNRNPD; RNF6; RUVBL2; ADNP; WWTR1; KAT5; RUNX1; TLE1; BRD3; TBPL1; EED; ZNF473; NKX3-1; CTR9; TRIM27; BCLAF1; CCDC59; FLNA; HMGA1; BLM; PUF60; BAZ1B; KAT7; EZH2; SMARCA5; FOXD1; MAX; ABL1; ZBTB24; CARM1; FOXM1; CBFB; PRPF6; BRPF1; PHF2; RFX5; C1QBP; CEBPG; UBP1; DDX54; DEK; HMGB1; ATF5; ENO1; NFKB1; TP53; RBBP7; ERBB2; APEX1; MED27; VEZF1; PMF1; CDK8; TAF4; ZBTB11; ZNF146; NCOA4; ELK3; CBX5; XRCC6; HSF2; CDC5L; YBX1; KDM2A; HSBP1; TBL1X; JARID2; NCOR1; HOXC10; NONO; NFE2L1; BATF; AFF1; BIRC2; ELK1; PURA; PPRC1; PBRM1; SF1; BMI1; HMGB3; YAF2; TRIM32; CTBP2; TSC22D2; TCF12; CRY1; ZBTB18; RNF4; COPS2; HMGB2; PIAS2; BRD8; HOXA10; CNOT6; CEBPZ; NR2F2; TFCP2; MTDH; HTATIP2; SOX9; NRIP1; HDAC1; SMARCD2; MED13; RNF138; TAF10; PRKDC; DDX5; BRCA1; TRRAP; EDF1; STAT6; PHF20; MYB; ARID4B; SUV39H1; PQBP1; CEBPA; ZNF410; ZKSCAN1; COPS5; CBX3; DDIT3; MED24; ILF2; SCAND1; MAGED1; EYA2; NCOR2; NFIB; GTF3A; TOB1; BASP1; BATF3; FOXC1; RREB1; CEBPB; TRIM29; ETS2; IKBKAP; TSC22D1; KDM5D