Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16124 Gsk-1059615 GSE70138 MCF10A Human 24h 3.33uM EID0005
Types Number Response transcription factors
Up-regulation 356 TSC22D3; SOX4; PNRC1; CALCOCO1; HBP1; EZH1; ZNF688; ZNF665; BPTF; MZF1; MED12; ZNF701; ZNF611; PRDM2; ELF4; EP300; ZNF117; PHIP; NR1H2; HDAC5; GLI2; ZNF268; ZBTB44; ZNF606; ZNF33B; NCOA3; ZNF536; HDAC6; ZNF500; ZNF91; CBFA2T2; TCF3; ZIC3; MEF2C; CEBPD; PCGF3; PRDM14; KAT2B; ST18; BTG1; SP4; KLF13; NR5A1; VGLL4; OVOL2; ZNF154; ATF2; ZBTB20; ZBTB3; RING1; SOX18; ASCL3; ZNF160; ZNF671; HLX; ZNF24; THRB; ZNF580; AFF2; ING4; ZNF816; IRF9; LHX3; ZMYND8; ZKSCAN4; SP100; NHLH1; FOXE3; ZNF304; ZNF175; SRCAP; DLX4; DCC; ZNF358; CAMTA2; PPARG; HNF4G; SALL2; ZNF586; ZNF254; RFX3; CBX7; LZTR1; ZNF250; ZNF135; ZFPM2; ZNF112; TSHZ2; ZNF43; ZNF350; VENTX; ZSCAN9; ZNF768; SOX12; PRDM9; ZNF345; CIR1; ZNF44; ARID5A; ZNF623; FOXH1; ZNF223; JUP; PHF1; LIN28A; FEZF2; ZNF85; TBX4; ZNF814; ATF4; ZNF667; MECP2; HIF3A; DAXX; ZNF444; PPP1R13L; ZNF83; ZNF211; CHD2; TBX1; SUPT3H; MAML3; INSR; L3MBTL1; CREBL2; CRX; MED25; IRF7; POU6F2; ZNF165; ZNF180; SCAI; BACH1; ZNF419; AEBP1; ZNF835; SUPT5H; LMCD1; TRAK1; ZNF415; IKZF1; BRWD1; ARID5B; ZNF711; ZFHX2; ZNF506; ZMIZ1; CUX2; BAZ2B; AHR; TLE2; ATOH1; FOXN3; PRDM12; HESX1; EMX1; HINFP; GCM1; CDIP1; NEUROG1; CARF; ZNF682; SPI1; TCF4; SUPT6H; ZNF257; GON4L; BARX1; SOX21; NR5A2; TSG101; NR1I3; RORC; ZNF217; GCM2; SETDB1; GRHL2; ZNF224; POU2F3; PAX4; KLF11; ZNF214; ZNF141; ERBB4; SRY; JUND; ZSCAN18; CIITA; ZBTB16; GATA6; ZNF80; ZNF329; TXNIP; SOX17; TBX21; ZNF362; ZNF75D; HIC1; SOX3; REL; ZNF81; PRDM10; HOXB1; ZNF467; ZNF423; GFI1B; GATA3; MXD4; TFCP2L1; ZNF93; MXI1; ZNF675; MDM2; ZBTB17; ZNF695; ARID3B; NEUROD1; PAWR; TFAP2A; MNT; PLAG1; IRF8; HMBOX1; ZNF264; ZNF587; CSDC2; HSF4; NEUROG2; TULP1; PROP1; DMTF1; ZNF573; E2F2; PEX14; THRA; ZNF674; ARNT; APBB1; ZFHX3; SHOX2; ZHX2; ZNF331; ZIC1; CBFA2T3; TCF7L2; ZBTB7A; NCOA2; FOXO3; WNT4; TEAD3; ZNF654; TWIST1; MED14; HSF1; TCEA2; TAL1; ZNF721; AES; BCL6; RARG; E2F5; VGLL1; TP73; POU2F2; TFEC; HOXB5; CBX4; POU2AF1; PIAS4; ZNF34; DLX5; SUPT4H1; TCF7L1; SOX2; NFATC1; RUNX1; NHLH2; SIX3; SMARCA1; KLF6; BNC2; SMAD6; CTBP1; TFDP2; TCF21; TRIM22; SKI; FOXO1; IRF6; SNAI2; TGFB1; ZNF239; ZSCAN16; ZNF354A; JAK2; ID3; TGIF1; NFATC4; CDYL; RSF1; BCL11A; BACH2; ZFHX4; NR1I2; NKX2-1; MEIS2; ZNF232; ESR1; SOX10; INSM1; ERBB2; KLF7; TGFB1I1; ZNF589; PDLIM1; MTA1; HOXD1; TRPS1; IRF1; NANOG; ID4; HEY2; CNOT3; HTATIP2; NR1H4; HOXB2; ZSCAN31; EN1; MYCL; HIPK1; ARNT2; PLAGL1; PBX1; ZFP36L1; NR1D2; KLF9; ZNF512B; TRIB3; MEOX2; VPS72; DACH1; KLF4; KLF2; OSR2; FOXO4; MYCN; HMG20B; MYRF; TRIM29; MYBL1; SSBP2; NFATC3; SPDEF; MAF; MAFB; ID1
Down-regulation 112 FOSL1; ADRB2; MYCBP; RUVBL1; TFDP1; EZH2; CCNA2; C1QBP; TBP; PSMC3IP; DRAP1; RBBP4; GTF2A2; MYC; PARP1; RUVBL2; CBFB; DNAJC2; MYBL2; HMGA2; PPRC1; HSBP1; BCLAF1; CRY1; RHOA; RAN; ORC2; PA2G4; MED6; WWTR1; ETS1; NUP62; BAZ1A; EED; RBM14; SMAD5; ENO1; NR2F2; WDR77; BMI1; HOXA10; MAX; CDK2; MTDH; HOXC10; RNF6; CALR; TRRAP; SF1; SFPQ; ECD; SMARCA2; SIX1; SSRP1; BHLHE40; PHF2; TFAM; NPM1; PIAS2; HDAC1; PRKDC; HNRNPD; IKBKAP; ITGB3BP; PITX1; SFMBT1; COPS5; JARID2; PUF60; STAT1; HOXC6; MNAT1; ETV4; CCDC59; FLNA; BRCA1; CNOT1; RNF138; BLM; XBP1; CTR9; TRIM32; ZBTB18; HMGB1; CCNC; CENPF; GATAD2A; RBBP7; CHD7; CEBPZ; NRIP1; LEF1; NKX3-1; POU4F1; HES1; SUB1; JUNB; ING2; HLTF; AFF1; FOXC1; EGR3; NR2F1; EDF1; PTTG1; ELK3; BCL11B; CITED1; HOXB7; PIR; STAT5B; SUV39H1