Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16087 Geldanamycin GSE70138 MCF10A Human 24h 10uM EID0004
Types Number Response transcription factors
Up-regulation 646 NFKB2; KDM5A; MEF2C; DMTF1; TRIM22; LYL1; ZKSCAN4; SCAI; DAXX; ZNF274; POU2F3; NR6A1; TXNIP; PHF1; ZBTB7C; VHL; ZNF135; ZSCAN16; ERBB4; DLX5; ZNF814; PBXIP1; ZNF157; ZNF254; RFX3; ASCL2; HIC1; ZSCAN31; ARID3A; HNF4G; SOHLH2; PKNOX1; ZNF492; ZXDB; SOX30; PRDM9; NHLH1; FLI1; ZNF506; ZNF257; GSC2; PRDM2; GCM2; FOXD3; RSF1; ZNF442; TBX5; CIITA; ZNF75D; WNT4; HOXD3; NEUROG3; KAT2B; ZNF287; SP140; ZBTB20; ZNF214; NR5A1; ZNF80; ZNF440; ZNF471; ZNF701; POU1F1; STAT5B; ZNF41; GCM1; SALL1; NKRF; DPF2; MED12; DCC; ZNF184; ZNF175; SOX18; ZNF362; ZSCAN9; ZBTB3; ZFP2; EHMT1; POU6F1; ZNF688; HIC2; SHOX; ETV2; ZNF674; FOXN1; NFE2; BRDT; PRDM10; ZXDC; MGA; RXRG; ETV3; FEZF2; SOX3; SRY; ZNF813; ZNF613; STAT2; NR3C1; POU6F2; PAX4; BARX1; ZNF79; THAP9; POU3F4; NFAT5; SOX14; SOX5; MECP2; ZBTB7B; ELF4; SCRT1; MAML3; ZNF682; ZNF248; CRX; EMX1; MYCN; ZNF493; ZNF345; FOXL2; PPARD; ZNF234; HAND2; ZNF446; ZFY; ZNF14; ASCL3; TAF1C; HNF4A; RXRB; MXD4; PPARA; BAZ2B; TAF12; GFI1B; ETV6; ZNF225; APBB1; ZNF507; NR3C2; MLLT1; TFDP2; TBX4; NPAS1; ZNF407; EVX1; ZNF81; BRWD1; GLI1; TBX6; ZNF749; HOXB8; SOX2; ID4; SMAD9; ZBTB48; HIF3A; NR2C2; ZNF695; STAT4; ZBTB44; CARF; TCF15; ZNF391; NKX6-1; ZNF467; HHEX; PLAG1; CDX1; IRF9; ZNF107; ARNT; ATOH1; ZKSCAN3; ZNF222; RBPJ; EZH1; ESRRB; LHX6; ZNF696; FOXE3; EP300; MSX2; ZIC4; FOXB1; SNIP1; ZNF253; GRIP1; ONECUT1; ZNF667; SPI1; SSX3; PFDN5; MSL3; TULP2; MED23; ZNF780B; TEF; ZNF500; HINFP; SIX6; PEG3; ZNF124; PML; SSX7; IRF7; DOT1L; FOXE1; ZNF835; FOXD2; FOXL1; ZNF573; TLX2; JUP; ZNF415; WHSC1L1; PRDM16; HESX1; ZNF606; CALCOCO1; GMEB1; FOXI1; CBFA2T2; LZTR1; REL; SOX1; RFX1; THRB; HOXC13; TEAD3; OSR2; HOXA2; TP73; ZNF334; FOXH1; ZNF76; PLAGL1; ZNF208; NR4A1; ZBED1; HOXA3; NR1I3; ZNF142; HOXD12; ZNF44; ZNF276; TBR1; ZNF654; CBFA2T3; NR1H2; TFAP2A; TRIM33; AFF2; ZNF331; MEF2D; DYRK1B; ZNF443; ZNF112; SMAD6; ZNF350; YEATS2; NR1H4; HES2; POU4F1; POLR3C; HOXB3; NEUROD2; ARID4A; ZSCAN5A; VAX2; ZNF117; GRHL2; CHD2; GBX2; UBTF; SP4; MBD4; ZNF556; HIVEP1; ZNF236; NR1I2; HSF4; ZNF329; HOXD13; PAX2; NR0B2; HMBOX1; KLF8; NKX2-8; DLX4; PGR; ZNF623; POU4F3; MAML1; ZMIZ2; TAF6L; ALX4; ZNF133; ZNF549; ZNF671; DLX2; SIX5; TCF4; ZNF778; NEUROG1; ZNF235; TCF21; ZFHX2; BCL11A; TBL1Y; PRDM8; ZNF74; ZNF16; PDX1; TRIM24; ZEB1; ETV7; ZFP30; ZNF529; TBX1; NEUROG2; HOXD1; RFXAP; ZNF711; RING1; SOX10; ZNF224; AIRE; L3MBTL1; ZNF675; ZNF646; NR5A2; CBL; NHLH2; IKZF2; ZNF423; TAF7L; MAFK; DLX6; BRF2; ZFP37; MEOX1; HLX; VENTX; ZNF273; ZNF174; MAPK8IP1; ZNF286A; ZNF212; JUN; MYCL; SOX12; HNF1A; ZNF292; E2F8; THRA; ALX3; STAT5A; TRPS1; ZNF3; ARRB1; TFCP2; ZNF141; CREM; TULP1; ZBTB39; MYF6; HOXA6; TMF1; ZNF250; AFF3; LIN28A; ZNF34; CBX4; NACA2; SETDB1; JAK2; CDK9; SIX3; ZNF550; ZNF571; PAX1; ZNF816; SUPT7L; RBPJL; ZNF10; POU3F3; HR; THAP7; TFEC; KDM4C; LBX1; ELF2; ZNF510; HNF1B; CBX7; BLZF1; KDM5D; CSDC2; CAMTA1; MYOG; ST18; ZFHX3; RORA; CDX2; MDM4; HOXD9; PRDM5; TONSL; FOXJ2; TCF25; SMAD4; PAX3; GLI2; ZNF85; MYNN; TAF1A; IKZF4; ZNF33B; HOXC11; CDX4; HDAC6; EYA3; ZNF154; MNX1; MED7; EP400; RBL1; IKZF3; E2F3; KLF1; HMGXB3; ZNF354A; ZNF384; KAT6A; ZNF165; MED14; MYF5; TGIF2; PITX3; CEBPA; DMRT1; ZNF219; MYBL1; LPIN2; FOXP3; GATA1; ZNF93; TGIF1; ATF6B; PRDM14; BPTF; NFATC1; PROP1; CERS4; ZSCAN18; SOX17; ZIC3; ZFP69B; MXD3; ING4; MSC; ELK4; SUPT6H; ZNF189; FOXO4; DEAF1; E4F1; SALL2; EGR4; NCOA1; ZNF536; GBX1; ZNF710; TULP4; BRCA1; ARID3B; TRIP11; TBX19; TWIST1; HABP4; ZNF335; HMX1; OVOL2; SIM1; HDAC5; PRDM13; POU2F2; ZNF215; ZKSCAN8; ARID5B; TSC22D3; FOXJ1; PRDM12; PBX1; NAB2; SMARCD3; CREBL2; SOX21; PHF20; POU4F2; PNRC1; IRF5; BACH2; CIR1; ZNF84; PHIP; SMARCA1; CUX1; ZNF268; LHX3; TRIB3; MYB; NANOG; TCEA2; TBX21; HOXD11; ZNF223; ZNF665; NCOA2; SPIB; ARL2BP; TEAD4; PKNOX2; PIAS4; KMT2A; NFX1; BAZ2A; ZNF516; ERBB2; TBX3; UIMC1; KDM5C; CUX2; NEUROD1; HOXD10; NFYC; NFIX; NKX3-2; TLX3; FOXJ3; GATA4; EN1; ZNF217; SP3; FOS; TAF11; NR4A2; ZNF304; ZNF394; CCNE1; VPS72; PRDM1; ANKRD1; PBX2; MZF1; FOXF2; TAL1; ZNF180; CEBPE; MAF; BNC2; KLF11; MEN1; SP2; TOX; TBL1X; USP21; RARG; LIMD1; SSBP2; NFE2L3; ZHX2; TULP3; BRCA2; ARID4B; MYT1L; NKX2-2; HOXC4; ZIC1; ACTL6B; HSBP1; ZNF227; PAX5; KDM5B; STAT1; SSBP3; SP140L; ZNF140; NKX2-1; ZFPM2; HOXB5; ARNT2; HBP1; FOXA2; PIR; TCF7; KLF3; MYRF; MEIS1; NR0B1; MECOM; INSR; PRMT2; FOXF1; AEBP1; AES; PAX6; SSX1; OLIG2; MNDA; ZBTB43; CREB3L1; ZNF43; CREB3L2; NLK; KAT6B; PAWR; ZBTB16; SOX11; FOSL2; ATF1; AFF1; TCF7L1; ZNF91; BACH1; IRF4; WT1; THAP10; BHLHE41; MEOX2; TCFL5; ESR1; HOXB2; KLF2; MEIS2; SPDEF; NFATC3; EGR3; HOXB6; TLE4; NFATC4; E2F2; GATA2
Down-regulation 166 MYC; CCNA2; MYCBP; ADRB2; NUP62; C1QBP; PTTG1; RUVBL2; NFIL3; PPRC1; CBFB; TLE1; NFKBIA; SPEN; SUZ12; DR1; HDAC2; CTBP1; SUB1; PARP1; CHD7; BIRC2; HMGB1; TCERG1; ATF4; FOSL1; GTF2A2; RAN; BMI1; VGLL4; XRCC6; ENO1; TBP; PA2G4; MTDH; GTF3A; NFKBIB; UBE2I; BCL3; SAP18; TFDP1; NELFB; DRAP1; KAT2A; CAPN15; CENPF; CRK; ZMYND11; HES1; EED; SUV39H1; MED1; ELK3; RNF4; KLF9; TFAM; SF1; GATAD2A; PTRF; NCOR2; PIAS2; ERF; THAP11; HDAC3; MAFF; CCNC; YAP1; MYBBP1A; KDM2A; TAF9; MNAT1; MXI1; BRPF1; CRY1; RBM14; IRF1; CBX3; ABL1; MAFB; YBX3; BRD3; SMAD5; MAZ; ZMYM2; EWSR1; SMARCD2; MED27; BHLHE40; MED21; IRF3; BAZ1A; XBP1; ZNF32; RBFOX2; TRIP6; ZNF22; MBD2; HMGN3; UBP1; BRD4; MNT; ZNF302; HMG20B; ITGB3BP; TCEA1; YBX1; ETS2; HNRNPD; YWHAB; RBL2; TRIM28; INSM1; RNF6; MEF2A; EDF1; APEX1; CEBPB; RFX5; CREB5; PMS1; STAT3; TSC22D2; PURA; ZBED2; DDX5; ZNF580; URI1; MSX1; CNBP; EMX2; FOXO1; RUNX3; HLTF; RERE; MED24; CDYL; ZNF264; CTBP2; EHF; HDAC9; MAX; HOXB7; CEBPG; SSRP1; SOX9; RBM39; PUF60; ZFP36L2; CEBPZ; JUNB; TAF10; SAP30; NFIB; ZNF652; PBX3; SNAI2; RBPMS; LITAF; VEZF1; KLF4; ETV1; NR2F2; ZBTB38; RELB; ZBTB18; NR2F1