Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16048 Linsitinib GSE70138 MCF10A Human 24h 3.33uM EID0004
Types Number Response transcription factors
Up-regulation 35 TSC22D3; RCOR1; SIM2; SMAD3; NR1H3; KLF5; ZMIZ1; MTF2; EDF1; MEF2A; HIPK3; HTATIP2; TAF10; ETS2; MAFB; SATB1; TRIM16; MECOM; HLTF; IRF1; HMGN3; JUNB; TRIM29; TSC22D1; LEF1; GATA2; SMARCA2; MAGED1; ZNF423; SAP30; TOX; PIR; BASP1; ELK3; TLE4
Down-regulation 55 MMS19; HESX1; CBFA2T2; ZIM2; CAMTA1; ATN1; MNX1; ZNF248; PEG3; NEUROD1; ENO1; POU2F1; IRF8; HLF; PRDM10; IL16; BTAF1; INSM1; SHOX2; APEX1; ACTL6B; MSC; WNT4; SOX10; SMARCB1; PA2G4; NKX2-1; ST18; CREB3L2; ZBTB20; IRX5; HHEX; OSR2; PAX6; HNRNPD; KLF6; BCL11A; KLF11; CREB1; JUN; IRF4; ID4; ZFPM2; HOXB2; RYBP; MEIS2; TFAP2C; NR2F6; ASCL1; ESR1; SPDEF; FOS; ZNF586; NFATC4; ZNF91