Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID16034 Nvp-bez235 GSE70138 MCF10A Human 24h 0.04uM EID0004
Types Number Response transcription factors
Up-regulation 159 PPARG; TGFB1I1; DMTF1; TSC22D3; NCOA3; HBP1; YEATS2; BCL10; REL; HINFP; PFDN5; HOXD1; ZNF33B; ZBTB16; MAFF; PBXIP1; SKIL; HIC1; MAFG; ELF4; ZNF688; ZNF654; ZBED1; ZNF467; EN1; SUPT3H; LOXL2; MED12; CREBL2; HDAC5; TLE2; GTF2IRD1; STAT2; TRIP11; ZNF91; NAB2; HMGA2; MECP2; ZNF239; SRCAP; CAMTA2; PNRC1; CBFA2T2; IRF7; SOX4; JUP; ZZZ3; CALCOCO1; NR1H3; PHF20; FEZF2; TBX3; SRY; TRIP4; SND1; IRF9; ID3; TCF25; BCL3; TGIF2; RBPJ; SIX2; ZNF768; BARX1; KDM5D; ZNF3; TBX1; ZNF532; EPAS1; ERBB2; ZKSCAN1; TGFB1; NFKB2; SREBF1; TSG101; ZNF112; ZFP36L1; SMAD6; TRIM22; SMARCA1; BCL6; IRF6; CREB3; ZMYM2; IFI16; CREM; LITAF; SMARCD3; NFE2L3; DDIT3; BTG1; BRWD1; KLF5; SMAD3; PAWR; KLF11; NKX2-1; EGR1; REPIN1; MYBL1; ZNF117; THAP11; RORA; HOXB13; PDLIM1; TOX3; RARG; TGIF1; PLAGL1; HHEX; HEY1; ING4; YAP1; SNAI2; NCOA4; ZNF217; FOS; ST18; TCF7L2; FOXF2; NRIP1; NEUROD1; FOXE1; CUX2; HTATIP2; MXI1; TWIST1; RBPMS; ATF3; VPS72; TULP3; TSC22D1; KLF9; ERBB4; TCEA2; SOX9; IRF8; FOXA2; ID1; IRF1; HIRA; FOXF1; TRIB3; SSX1; RELB; SCAND1; TRPS1; ARNT2; GATA6; ZIC1; ARID5B; NKX3-1; MAF; MECOM; OLIG2; ZBED2; TRIM29; NFATC4; MEIS2
Down-regulation 96 CCNA2; MYBL2; MYCBP; TCERG1; PARP1; GTF2A2; FOXM1; PTTG1; WHSC1; CENPF; HSF2; ATF5; RBM14; RUVBL1; SUV39H1; BCLAF1; HMGB2; MXD1; PRKDC; SUB1; CCDC59; RAN; ZNF200; CHAF1B; UBP1; ENO1; BRCA1; PSMC3IP; RUVBL2; TOPORS; HMGB1; PA2G4; BATF3; CNOT6; MYB; WDHD1; ZSCAN31; ADNP2; SFPQ; PREB; SP2; TFDP1; HLTF; ING3; NUP62; MED1; TRRAP; RBBP8; HMG20A; IRX5; ILF2; HOXB7; CRY1; RFX5; MSX1; TAF9; C1QBP; SHOX2; FOXC1; PURA; RNF4; POU2AF1; XBP1; AFF1; TOB1; SMAD1; BMI1; HOXC6; ESR1; DNMT3B; BLM; YWHAB; ZBTB18; BCL11B; CEBPG; TRIM28; JARID2; PIR; CCNE1; HNRNPD; RNF6; ZEB2; MAFB; SIAH2; HOXC10; FOSL1; IKBKAP; MNDA; MAGED1; NR4A2; WT1; HMGN3; ASCL1; NR2F2; NR2F1; PUF60