Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID15976 Torin-2 GSE70138 MCF10A Human 24h 0.12uM EID0004
Types Number Response transcription factors
Up-regulation 272 NFKBIB; TSC22D3; TGFB1I1; ZNF337; CALCOCO1; RING1; PNRC1; IRF9; HDAC9; ZNF611; NCOA3; ZNF573; ZNF500; ZNF688; ZNF345; AFF2; TADA3; ZKSCAN4; HINFP; EZH1; YEATS2; POU6F1; ID4; NR1I3; HDAC11; ZNF235; ZNF669; FOXF2; ZNF589; CEBPD; ZNF33B; HDAC5; ZNF667; TUB; SOX4; SIRT2; ZNF358; KAT2B; CDIP1; ZNF768; ZKSCAN3; THRB; MXI1; ZBTB16; PROP1; RBPJ; FOXN3; HMBOX1; SUPT3H; TEAD3; ZNF112; ZNF208; PRDM14; TULP1; GLI2; LZTR1; PBXIP1; POU6F2; ZNF133; TBX5; ZNF665; ZNF160; CERS4; MEF2C; SOX17; NHLH1; ING4; TBX10; CREBL2; TLX1; PHF1; ZNF93; BRD4; ZNF44; ZFP30; RSF1; SRY; RFXANK; ZNF701; BPTF; TAF7L; SCAI; ZBTB44; ZNF154; KLF11; HBP1; JUND; TFEB; ST18; ATOH1; ZNF654; ELF4; TCEA2; ZNF257; SETDB1; SUPT7L; BCL11A; PPARD; NEUROD2; ATF2; DLX4; LOXL2; MNT; ZFHX3; SUPT5H; NFE2L1; LHX3; ZNF536; BTG1; ZIC3; SSBP3; KLF13; THRA; NEUROG1; FEZF2; MED12; CBX7; ZNF223; NRL; PFDN5; TBX1; ZNF85; ZNF253; FOXJ2; KLF7; ZNF264; PRDM1; ZNF132; ZNF135; TOX3; LMO1; STAT2; HOXD1; TAF6L; NEUROD1; TERF2; ATN1; SRCAP; MTA1; ZNF571; CRTC1; FOXA2; CDK7; ZNF444; SOX5; E2F5; ERBB2; MYBL1; ZNF415; OVOL2; WNT4; ZNF467; APEX1; ZNF141; IRF6; BRWD1; POU2F2; ACTL6B; CBX2; ZBED1; SKI; PDLIM1; ZBTB43; NR1I2; ZNF623; ZNF532; ZNF606; AR; EP300; TCF7; RORA; SKIL; EHMT2; BARX1; PLAG1; VPS72; ZNF423; ZFP36L2; SALL2; MZF1; RARG; SOX18; INSM1; ZNF12; FOXI1; ZNF91; HOXB13; MEIS1; RARB; HOXB1; SMAD6; SPDEF; PPP1R13L; FOXD1; THAP11; NR1H2; ZKSCAN7; PGR; MAFF; DLX5; ZNF117; ARL2BP; TCF12; CHD9; CIZ1; NAB2; FOXF1; KLF9; KLF1; LMCD1; REL; ZNF512B; ZNF580; ELF3; TCF3; LITAF; NCOR2; AES; BNC2; SNAI2; LIN28A; POU2AF1; TRIM22; MYRF; MYCL; IFI16; HOXB2; SPIB; MXD4; MAF; ZSCAN18; CBFA2T3; SOX13; IRF8; SMARCD3; TRIB3; RXRA; TGFB1; BCL6; TAL1; TCF4; TCF7L1; ERBB4; TULP3; SMAD7; ZEB1; TCF7L2; PBX1; SMARCA1; INSR; TBX3; EHF; FOXO1; FOS; BACH2; SSBP2; MECOM; CRYM; ESR1; OLIG2; TRPS1; ZIC1; ARID5B; KAT6B; ZHX2; RELB; GATA6; TRIM29; MEIS2; BHLHE41; NFATC4; KDM5D
Down-regulation 114 CCNA2; MYCBP; MYBL2; TCERG1; PARP1; EZH2; TBP; GABPB1; ITGB3BP; HMGB1; EED; FOXM1; GTF2A2; NUP62; BAZ1B; RUVBL1; TFDP1; PSMC3IP; SFPQ; TFAM; CENPF; HSF2; BCLAF1; CBFB; RBM14; BRCA1; WHSC1; SUV39H1; SMARCA5; BLM; RAN; CBX5; HLTF; XRCC6; PA2G4; RBBP4; HMGB2; HOXC6; PIAS2; C1QBP; RNF138; DNAJC2; CTR9; BAZ1A; SUB1; KDM2A; RNF6; RUVBL2; WDHD1; PURA; NPAT; BATF3; PTTG1; SMARCE1; KMT5A; SMARCC1; ZMYM2; TAF9; ORC2; SNW1; ZNF107; TBPL1; IRX5; CCNC; HDAC1; SSRP1; RBBP8; TRRAP; ING3; BRD8; CRY1; HNRNPD; AATF; TOB1; ETS2; CEBPZ; HOXB7; LEF1; AFF1; DNMT3B; CHD1; HOXC10; USP22; XBP1; SF1; MBD2; FOXC1; ELF1; CHD7; RFX5; MAGED1; HMGN3; PUF60; TBL1XR1; BMI1; TSC22D2; FUBP1; MED1; NFIB; PITX1; RBBP7; TRIM28; NR2F2; ZBTB18; WWTR1; ATF1; FOSL1; MYB; ISL1; ID2; SAP30; TRIP6; PBX3; E2F2